HK1226347A1 - Aramchol鹽 - Google Patents

Aramchol鹽

Info

Publication number: HK1226347A1
Authority: HK; Hong Kong
Prior art keywords: aramchol salts; aramchol; salts
Prior art date: 2013-12-04

Application number

HK16114629A

Other languages

English (en)

Inventor

Allen Baharaff

Idit Eshkar-Oren

Original Assignee

Galmed Res & Development Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-04

Filing date

2016-12-22

Publication date

2017-09-29

2016-12-22 Application filed by Galmed Res & Development Ltd filed Critical Galmed Res & Development Ltd

2017-09-29 Publication of HK1226347A1 publication Critical patent/HK1226347A1/zh

Links

SHKXZIQNFMOPBS-OOMQYRRCSA-N (4r)-4-[(3s,5s,7r,8r,9s,10s,12s,13r,14s,17r)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoic acid Chemical class O[C@H]1C[C@@H]2[C@@]3(C)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC)C[C@H]3C[C@@H](O)[C@H]2[C@@H]2CC[C@H]([C@H](C)CCC(O)=O)[C@]21C SHKXZIQNFMOPBS-OOMQYRRCSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/05—Mono-, di- or tri-ethylamine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Epidemiology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HK16114629A 2013-12-04 2016-12-22 Aramchol鹽 HK1226347A1 (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361911478P	2013-12-04	2013-12-04

Publications (1)

Publication Number	Publication Date
HK1226347A1 true HK1226347A1 (zh)	2017-09-29

Family

ID=53272986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK16114629A HK1226347A1 (zh)	2013-12-04	2016-12-22	Aramchol鹽

Country Status (22)

Country	Link
US (1)	US20160304553A1 (zh)
EP (1)	EP3077047B1 (zh)
JP (2)	JP6675310B2 (zh)
KR (1)	KR102320191B1 (zh)
CN (2)	CN105848718B (zh)
AU (2)	AU2014358668B2 (zh)
BR (1)	BR112016012465B1 (zh)
CA (1)	CA2930232C (zh)
CY (1)	CY1121736T1 (zh)
DK (1)	DK3077047T3 (zh)
ES (1)	ES2732845T3 (zh)
HK (1)	HK1226347A1 (zh)
HR (1)	HRP20191023T1 (zh)
HU (1)	HUE045209T2 (zh)
LT (1)	LT3077047T (zh)
PL (1)	PL3077047T3 (zh)
PT (1)	PT3077047T (zh)
RS (1)	RS59067B1 (zh)
SI (1)	SI3077047T1 (zh)
SM (1)	SMT201900363T1 (zh)
TR (1)	TR201909447T4 (zh)
WO (1)	WO2015083164A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL227890A0 (en) *	2013-08-08	2014-01-30	Galderm Therapeutics Ltd	Antiaging compounds containing bile acid and fatty acid conjugates
WO2015083164A1 (en) *	2013-12-04	2015-06-11	Galmed Research & Development Ltd.	Aramchol salts
US10849911B2 (en)	2015-06-10	2020-12-01	Galmed Research And Development Ltd.	Low dose compositions of Aramachol salts
CN108337879B (zh) *	2015-07-12	2021-01-19	西夫索有限公司	硫酸胆钙化醇的盐及其用于治疗维生素d3缺乏的用途
WO2017017677A1 (en) *	2015-07-27	2017-02-02	Galmed Research And Development Ltd.	Combination treatment for liver disease
IL243707A0 (en)	2016-01-20	2016-05-01	Galmed Res And Dev Ltd	Treatment to regulate the microbiota in the intestine
FR3050112B1 (fr)	2016-04-15	2020-09-04	Soc Civ Immobiliere Gecinq	Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques
KR102399254B1 (ko) *	2016-09-28	2022-05-17	아이거 바이오파마슈티컬스 인코포레이티드	비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물
US11197870B2 (en)	2016-11-10	2021-12-14	Galmed Research And Development Ltd	Treatment for hepatic fibrosis
MX2019005531A (es) *	2016-11-10	2019-09-16	Galmed Res And Development Ltd	Inhibicion de la fibrosis en pacientes con enfermedad de higado graso no alcoholico.
CN110730785B (zh) *	2017-06-07	2022-05-17	苏州科睿思制药有限公司	一种脂肪酸胆汁酸偶合物的晶型及其制备方法和用途
WO2019125913A1 (en) *	2017-12-20	2019-06-27	Michael Guarnieri	Nutritional bolus for animals
WO2020026471A1 (ja) *	2018-07-31	2020-02-06	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
JP6612004B1 (ja) *	2018-07-31	2019-11-27	株式会社親広産業	グルコース消費促進剤および解糖系促進剤
US12090151B1 (en)	2023-05-12	2024-09-17	Michael Guarnieri	Injectable sustained release buprenorphine formulation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2252863A (en) *	1941-02-03	1941-08-19	Searle & Co	Quaternary ammonium salts
GB1532413A (en) *	1974-12-23	1978-11-15	Union International Co Ltd	Chenodeoxycholic acid
IL142650A (en) *	1998-04-08	2007-06-03	Galmed Int Ltd	Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
IL123998A (en) *	1998-04-08	2004-09-27	Galmed Int Ltd	Conjugates of bile salts and pharmaceutical preparations containing them
US8975246B2 (en) *	2001-04-17	2015-03-10	Galmed Research And Development Ltd.	Bile acid or bile salt fatty acid conjugates
ITMI20061735A1 (it) *	2006-09-12	2008-03-13	Dipharma Spa	Procedimento per la preparazione di acidi colanici
DE102007032507A1 (de) *	2007-07-12	2009-04-02	Merck Patent Gmbh	Pyridazinonderivate
WO2010086864A1 (en) *	2009-02-02	2010-08-05	Galmed International Ltd.	Methods and compositions for treating alzheimer's disease
CN102115486B (zh) *	2009-12-30	2015-06-03	上海特化医药科技有限公司	一种3-β-花生酰胺基-7α,12α,5β-胆烷-24-羧酸的制备方法
JP2013518110A (ja) *	2010-01-28	2013-05-20	メルク・シャープ・エンド・ドーム・コーポレイション	疼痛および他の適応症の治療用の医薬組成物
DK2531501T3 (en) *	2010-02-03	2014-02-24	Takeda Pharmaceutical	APOPTOSESIGNALREGULERENDE KINASE 1 inhibitors
CN103596566B (zh) *	2010-12-07	2017-08-25	阿米拉制药公司	多环lpa1拮抗剂及其使用
WO2015083164A1 (en) *	2013-12-04	2015-06-11	Galmed Research & Development Ltd.	Aramchol salts

2014
- 2014-12-04 WO PCT/IL2014/051052 patent/WO2015083164A1/en active Application Filing
- 2014-12-04 PT PT14868582T patent/PT3077047T/pt unknown
- 2014-12-04 LT LTEP14868582.9T patent/LT3077047T/lt unknown
- 2014-12-04 KR KR1020167017460A patent/KR102320191B1/ko active Active
- 2014-12-04 US US15/100,993 patent/US20160304553A1/en not_active Abandoned
- 2014-12-04 RS RS20190787A patent/RS59067B1/sr unknown
- 2014-12-04 AU AU2014358668A patent/AU2014358668B2/en active Active
- 2014-12-04 CN CN201480064913.8A patent/CN105848718B/zh active Active
- 2014-12-04 PL PL14868582T patent/PL3077047T3/pl unknown
- 2014-12-04 HU HUE14868582A patent/HUE045209T2/hu unknown
- 2014-12-04 SI SI201431253T patent/SI3077047T1/sl unknown
- 2014-12-04 ES ES14868582T patent/ES2732845T3/es active Active
- 2014-12-04 BR BR112016012465-0A patent/BR112016012465B1/pt active IP Right Grant
- 2014-12-04 JP JP2016535210A patent/JP6675310B2/ja active Active
- 2014-12-04 DK DK14868582.9T patent/DK3077047T3/da active
- 2014-12-04 SM SM20190363T patent/SMT201900363T1/it unknown
- 2014-12-04 TR TR2019/09447T patent/TR201909447T4/tr unknown
- 2014-12-04 EP EP14868582.9A patent/EP3077047B1/en active Active
- 2014-12-04 CA CA2930232A patent/CA2930232C/en active Active
- 2014-12-04 CN CN201910687060.8A patent/CN110437298A/zh active Pending
2016
- 2016-12-22 HK HK16114629A patent/HK1226347A1/zh unknown
2019
- 2019-06-06 HR HRP20191023TT patent/HRP20191023T1/hr unknown
- 2019-07-01 CY CY20191100688T patent/CY1121736T1/el unknown
- 2019-12-06 AU AU2019275638A patent/AU2019275638B2/en active Active
2020
- 2020-03-10 JP JP2020040825A patent/JP2020111584A/ja active Pending

Also Published As

Publication number	Publication date
DK3077047T3 (da)	2019-07-15
CY1121736T1 (el)	2020-07-31
RS59067B1 (sr)	2019-09-30
AU2014358668A1 (en)	2016-06-02
CN110437298A (zh)	2019-11-12
JP2020111584A (ja)	2020-07-27
TR201909447T4 (tr)	2019-07-22
LT3077047T (lt)	2019-08-26
AU2019275638B2 (en)	2021-05-06
KR20160093051A (ko)	2016-08-05
EP3077047A4 (en)	2017-05-03
JP6675310B2 (ja)	2020-04-01
CN105848718B (zh)	2019-07-30
AU2014358668B2 (en)	2019-10-24
CA2930232A1 (en)	2015-06-11
WO2015083164A1 (en)	2015-06-11
KR102320191B1 (ko)	2021-11-03
ES2732845T3 (es)	2019-11-26
US20160304553A1 (en)	2016-10-20
PT3077047T (pt)	2019-07-11
CN105848718A (zh)	2016-08-10
EP3077047B1 (en)	2019-04-24
JP2016539131A (ja)	2016-12-15
HRP20191023T1 (hr)	2019-09-06
PL3077047T3 (pl)	2019-10-31
AU2019275638A1 (en)	2020-01-23
SI3077047T1 (sl)	2019-09-30
BR112016012465A8 (pt)	2020-05-05
EP3077047A1 (en)	2016-10-12
CA2930232C (en)	2020-09-15
BR112016012465B1 (pt)	2023-04-18
HUE045209T2 (hu)	2019-12-30
SMT201900363T1 (it)	2019-09-09

Publication	Publication Date	Title
DK3689865T3 (en)	2023-06-19	Hidtil ukendte aminopyrimidinderivater
HK1222846A1 (zh)	2017-07-14	取代的苄基吡唑
HK1221717A1 (zh)	2017-06-09	取代的苄基吡唑
HK1226347A1 (zh)	2017-09-29	Aramchol鹽
HK1213876A1 (zh)	2016-07-15	取代的咪唑並噠嗪
HK1223362A1 (zh)	2017-07-28	取代的吡唑並吡啶胺
HK1220972A1 (zh)	2017-05-19	取代的噻唑並嘧啶
PL3068827T3 (pl)	2018-07-31	Kompozycja bitum/polimer o poprawionych właściwościach mechanicznych na zimno
IL246271A0 (en)	2016-08-02	Converted piperidinyl-tetrahydroquinolines
DK3056208T3 (en)	2021-11-15	Immunpotentiator
PL2846091T3 (pl)	2017-08-31	Palnik gazu utleniającego z zapłonem żarowym
GB201311130D0 (en)	2013-08-07	Greensleeves I
HUP1300504A2 (en)	2015-03-30	Sorafenib salts
GB201300001D0 (en)	2013-02-13	Envirep - environment replicater
IL245452B (en)	2020-09-30	Salts of Armachol
GB2519519B (en)	2016-05-18	Stop
AU4899P (en)	2014-08-15	Herbie53 Iresine herbstii
AU353329S (en)	2014-01-21	Kettlebell
AU2013099V (en)	2013-12-02	Little Lorey Chamelaucium floriferum
GB201309272D0 (en)	2013-07-10	Lifelite
GB201309271D0 (en)	2013-07-10	Shovelite
GB201308589D0 (en)	2013-06-19	iCCap
GB201307370D0 (en)	2013-06-05	I-Mirror
GB201307225D0 (en)	2013-05-29	Facelets
GB201306074D0 (en)	2013-05-22	Archxibow