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HK1213285A1 - 用於優化灌流細胞培養系統的方法和系統 - Google Patents

用於優化灌流細胞培養系統的方法和系統

Info

Publication number
HK1213285A1
HK1213285A1 HK16101154.2A HK16101154A HK1213285A1 HK 1213285 A1 HK1213285 A1 HK 1213285A1 HK 16101154 A HK16101154 A HK 16101154A HK 1213285 A1 HK1213285 A1 HK 1213285A1
Authority
HK
Hong Kong
Prior art keywords
systems
methods
cell culture
culture system
perfusion cell
Prior art date
Application number
HK16101154.2A
Other languages
English (en)
Inventor
Yuval Shimoni
Volker Mhrle
Venkatesh Srinivasan
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HK1213285A1 publication Critical patent/HK1213285A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16101154.2A 2012-10-10 2016-02-02 用於優化灌流細胞培養系統的方法和系統 HK1213285A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712190P 2012-10-10 2012-10-10
PCT/US2013/064159 WO2014059035A1 (en) 2012-10-10 2013-10-09 Methods and systems for optimizing perfusion cell culture system

Publications (1)

Publication Number Publication Date
HK1213285A1 true HK1213285A1 (zh) 2016-06-30

Family

ID=49448331

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101154.2A HK1213285A1 (zh) 2012-10-10 2016-02-02 用於優化灌流細胞培養系統的方法和系統

Country Status (15)

Country Link
US (2) US20150299638A1 (zh)
EP (1) EP2906677A1 (zh)
JP (1) JP6393267B2 (zh)
KR (1) KR20150063541A (zh)
CN (1) CN104822821A (zh)
AR (1) AR092967A1 (zh)
AU (1) AU2013329318A1 (zh)
CA (1) CA2887581A1 (zh)
HK (1) HK1213285A1 (zh)
IL (1) IL238179A0 (zh)
MX (1) MX2015004516A (zh)
RU (1) RU2015117547A (zh)
SG (2) SG10201705806YA (zh)
TW (1) TW201418455A (zh)
WO (1) WO2014059035A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9944894B2 (en) 2015-01-16 2018-04-17 General Electric Company Pluripotent stem cell expansion and passage using a rocking platform bioreactor
CN105385731B (zh) * 2015-12-25 2018-10-30 上海莱士血液制品股份有限公司 一种表达重组八因子的灌注培养方法
ITUB20160272A1 (it) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D
CN108779424A (zh) * 2016-03-21 2018-11-09 通用电气公司 使用搅拌槽生物反应器的多能干细胞扩增和传代
JP7323512B2 (ja) 2017-10-06 2023-08-08 ロンザ リミテッド ラマン分光法を使用する細胞培養の自動制御
TW202426623A (zh) 2017-10-16 2024-07-01 美商再生元醫藥公司 灌注生物反應器及相關使用方法
EP3797149A1 (en) * 2018-05-22 2021-03-31 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
US20210214702A1 (en) * 2018-06-01 2021-07-15 Gennova Biopharmaceuticals Limited Process for production of recombinant tnk-tpa by packed-bed perfusion system
EP3875595A4 (en) * 2018-11-02 2022-07-13 Kyowa Kirin Co., Ltd. Liquid medium preparation method
GB201903813D0 (en) * 2019-03-20 2019-05-01 Cn Bio Innovations Ltd Dual circulation microphysiological system
WO2020232183A1 (en) * 2019-05-15 2020-11-19 Life Technologies Corporation Cell settler apparatus systems and methods for perfusion processes
WO2021089661A1 (en) * 2019-11-07 2021-05-14 Merck Patent Gmbh Methods and systems for performing perfusion cell culture
WO2021110870A1 (en) 2019-12-05 2021-06-10 Acib Gmbh Method for producing a fermentation product

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6338964B1 (en) 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
US20040185534A1 (en) * 2000-10-02 2004-09-23 Knudsen Ida Molgaard Industrial-scale serum-free production of recombinant proteins in mammalian cells
AU2004286351A1 (en) * 2003-11-03 2005-05-12 Centocor, Inc. Method for maintaining low shear in a bioprocessing system
US20090280565A1 (en) * 2005-12-22 2009-11-12 Corporation De L'ecole Polytechique Montr'eal High-rate perfusion bioreactor
CN101473029A (zh) * 2006-04-21 2009-07-01 拜尔健康护理有限责任公司 抗凋亡基因在用于灌注培养的哺乳动物细胞中的应用
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
EA019812B1 (ru) * 2008-06-13 2014-06-30 Сентокор Орто Байотек Инк. Способы получения высокой плотности жизнеспособных клеток в культуре клеток млекопитающих
JP5923529B2 (ja) * 2011-03-18 2016-05-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養用可撓性バッグ

Also Published As

Publication number Publication date
KR20150063541A (ko) 2015-06-09
US20150299638A1 (en) 2015-10-22
WO2014059035A1 (en) 2014-04-17
AR092967A1 (es) 2015-05-06
EP2906677A1 (en) 2015-08-19
US20140099711A1 (en) 2014-04-10
RU2015117547A (ru) 2016-12-10
SG11201502741WA (en) 2015-05-28
MX2015004516A (es) 2015-10-14
JP6393267B2 (ja) 2018-09-19
TW201418455A (zh) 2014-05-16
IL238179A0 (en) 2015-05-31
SG10201705806YA (en) 2017-08-30
CN104822821A (zh) 2015-08-05
CA2887581A1 (en) 2014-04-17
AU2013329318A1 (en) 2015-05-14
JP2015531241A (ja) 2015-11-02

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