HK1211591A1 - Triterpene saponins, methods of synthesis, and uses thereof - Google Patents

Triterpene saponins, methods of synthesis, and uses thereof

Info

Publication number: HK1211591A1
Authority: HK; Hong Kong
Prior art keywords: synthesis; methods; triterpene saponins; triterpene; saponins
Prior art date: 2008-04-08

Application number

HK15112457.4A

Other languages

English (en)

Chinese (zh)

Inventor

戴維‧金

米歇爾‧亞當斯

鄧凱

尼古拉斯‧佩爾

安妮‧汪

菲利普‧利文斯頓

戈文德‧拉古帕蒂

Original Assignee

Sloan Kettering Inst Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-08

Filing date

2015-12-17

Publication date

2016-05-27

2015-12-17 Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer

2016-05-27 Publication of HK1211591A1 publication Critical patent/HK1211591A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Mycology (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Pulmonology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HK15112457.4A 2008-04-08 2015-12-17 Triterpene saponins, methods of synthesis, and uses thereof HK1211591A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4319708P	2008-04-08	2008-04-08

Publications (1)

Publication Number	Publication Date
HK1211591A1 true HK1211591A1 (en)	2016-05-27

Family

ID=40875147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK15112457.4A HK1211591A1 (en)	2008-04-08	2015-12-17	Triterpene saponins, methods of synthesis, and uses thereof

Country Status (11)

Country	Link
US (5)	US8283456B2 (xx)
EP (3)	EP3868771A1 (xx)
JP (5)	JP5706815B2 (xx)
KR (6)	KR102453184B1 (xx)
CN (2)	CN104710487A (xx)
AU (1)	AU2009233757B2 (xx)
CA (3)	CA2993582C (xx)
ES (1)	ES2827804T3 (xx)
HK (1)	HK1211591A1 (xx)
IL (4)	IL208535A (xx)
WO (1)	WO2009126737A2 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2993582C (en)	2008-04-08	2020-12-15	Sloan-Kettering Institute For Cancer Research	Triterpene saponins, methods of synthesis, and uses thereof
CN102068446B (zh) *	2011-01-10	2013-08-21	武汉道一堂医药研究院	三萜皂苷化合物在制备抗病原微生物药物中的应用
AU2013204005B2 (en) *	2012-05-23	2015-04-16	Oncology Research International Limited	Improved synthesis
CA2897084C (en)	2013-01-04	2019-07-16	Cheng Der Tony Yu	Vaccines with higher carbohydrate antigen density and novel saponin adjuvant
US10806119B2 (en)	2013-06-05	2020-10-20	Yeda Research And Development Co. Ltd.	Plant with altered content of steroidal alkaloids
SG11201510740YA (en)	2013-09-17	2016-01-28	Obi Pharma Inc	Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
CN106573951B (zh) *	2014-05-30	2020-09-11	索隆-基特林癌症研究协会	微小皂苷类似物、合成及其用途
WO2017041027A1 (en)	2015-09-04	2017-03-09	Obi Pharma, Inc.	Glycan arrays and method of use
WO2017079582A1 (en)	2015-11-06	2017-05-11	Adjuvance Technologies, Inc.	Triterpene saponin analogues
EP3436482A4 (en)	2016-03-29	2020-03-11	OBI Pharma, Inc.	ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
US10980894B2 (en)	2016-03-29	2021-04-20	Obi Pharma, Inc.	Antibodies, pharmaceutical compositions and methods
CN109379889A (zh)	2016-04-22	2019-02-22	台湾浩鼎生技股份有限公司	通过经由globo系列抗原的免疫激活或免疫调节的癌症免疫疗法
KR20230117482A (ko)	2016-07-27	2023-08-08	오비아이 파머 인코퍼레이티드	면역원성/치료 글리칸 조성물 및 그의 용도
US11643456B2 (en)	2016-07-29	2023-05-09	Obi Pharma, Inc.	Human antibodies, pharmaceutical compositions and methods
AU2017361549B2 (en)	2016-11-21	2023-12-21	Obi Pharma, Inc.	Conjugated biological molecules, pharmaceutical compositions and methods
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
AU2018253267B2 (en) *	2017-04-13	2024-02-29	Adjuvance Technologies, Inc.	Triterpene saponin synthesis, intermediates and adjuvant combinations
CA3061205A1 (en) *	2017-04-25	2018-11-01	Adjuvance Technologies, Inc.	Triterpene saponin analogues
JP7177082B2 (ja) *	2017-04-25	2022-11-22	アジュバンス・テクノロジーズ・インコーポレーテッド	トリテルペンサポニン類似物
EP3697802A4 (en)	2017-10-16	2021-11-24	Adjuvance Technologies, Inc.	TRITERPENIC SAPONIN ANALOGUES
CN111566117A (zh)	2017-12-29	2020-08-21	糖模拟物有限公司	E-选择蛋白和半乳凝素-3的异双功能抑制剂
US20210040143A1 (en) *	2018-03-20	2021-02-11	The Uab Research Foundation	Saponin-based vaccine adjuvants
TWI853822B (zh)	2018-06-27	2024-09-01	台灣浩鼎生技股份有限公司	用於糖蛋白工程的糖苷合成酶變體及其使用方法
SG11202102106RA (en)	2018-09-06	2021-04-29	Yeda Res & Dev	Cellulose-synthase-like enzymes and uses thereof
EP3849521A1 (en)	2018-09-14	2021-07-21	Massachusetts Institute Of Technology	Nanoparticle vaccine adjuvant and methods of use thereof
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3
EP3902797A1 (en)	2018-12-27	2021-11-03	GlycoMimetics, Inc.	Galectin-3 inhibiting c-glycosides
US20220409721A1 (en) *	2019-11-05	2022-12-29	Adjuvance Technologies, Inc.	Varicella zoster
US20230128815A1 (en) *	2020-03-23	2023-04-27	Adjuvance Technologies, Inc.	Adjuvant compounds, salt forms, and formulations
WO2023052829A1 (en) *	2021-10-02	2023-04-06	Desert King Chile S.A	A 3-o-monodesmosidic saponins extract, stable at physiological ph, method for preparing it from a quillaja plant extract cultured with a microbial consortium, uses and such microbial consortium
EP4190359A1 (en)	2021-12-03	2023-06-07	Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE	Saponin-based adjuvants and vaccines
WO2023114570A1 (en)	2021-12-19	2023-06-22	Massachusetts Institute Of Technology	Compositions and methods for long-lasting germinal center responses to a priming immunization
EP4466278A1 (en)	2022-01-19	2024-11-27	Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE	Saponin-based adjuvants and vaccines
WO2024218268A1 (en)	2023-04-20	2024-10-24	Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune	Saponin derivatives as adjuvants and photoaffinity probes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6112695A (ja) *	1984-06-28	1986-01-21	Rikagaku Kenkyusho	シアル酸誘導体
US5583112A (en)	1987-05-29	1996-12-10	Cambridge Biotech Corporation	Saponin-antigen conjugates and the use thereof
US5057540A (en) *	1987-05-29	1991-10-15	Cambridge Biotech Corporation	Saponin adjuvant
JPH09169648A (ja) *	1995-12-22	1997-06-30	Nippon Shinyaku Co Ltd	医薬組成物
WO1998024319A1 (en) *	1996-12-02	1998-06-11	Aquila Biopharmaceuticals, Inc.	Novel saponin compositions and uses thereof
US6231859B1 (en) *	1996-12-02	2001-05-15	Aquila Biopharmaceuticals, Inc.	Saponin adjuvant compositions
US6080725A (en)	1997-05-20	2000-06-27	Galenica Pharmaceuticals, Inc.	Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
WO1998052573A1 (en)	1997-05-20	1998-11-26	Galenica Pharmaceuticals, Inc.	Triterpene saponin analogs having adjuvant and immunostimulatory activity
EP0988053A1 (en) *	1997-06-11	2000-03-29	Aquila Biopharmaceuticals, Inc.	Purified saponins as oral adjuvants
WO2000009075A2 (en)	1998-08-14	2000-02-24	Galenica Pharmaceuticals, Inc.	Chemically modified saponins and the use thereof as adjuvants
US7457415B2 (en)	1998-08-20	2008-11-25	Akikaze Technologies, Llc	Secure information distribution system utilizing information segment scrambling
US6716428B1 (en)	1999-10-06	2004-04-06	The Ohio State University Research Foundation	Antigenic modification of polypeptides
WO2004092329A2 (en) *	2003-04-08	2004-10-28	Galenica Pharmaceuticals, Inc.	Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
AU2006243737A1 (en) *	2005-05-04	2006-11-09	National Research Council Of Canada	Method for production of Saponaria from microspores
CN100335073C (zh) *	2005-08-19	2007-09-05	浙江大学	木鳖子含三萜皂甙成分提取物的制备方法
CA2993582C (en) *	2008-04-08	2020-12-15	Sloan-Kettering Institute For Cancer Research	Triterpene saponins, methods of synthesis, and uses thereof
CN101322734B (zh)	2008-07-22	2013-05-29	沈阳药科大学	具有抗炎免疫作用的轮叶党参总皂苷及其制备方法
CN106573951B (zh) *	2014-05-30	2020-09-11	索隆-基特林癌症研究协会	微小皂苷类似物、合成及其用途

2009
- 2009-04-08 CA CA2993582A patent/CA2993582C/en active Active
- 2009-04-08 CN CN201510047889.3A patent/CN104710487A/zh active Pending
- 2009-04-08 EP EP20186996.3A patent/EP3868771A1/en active Pending
- 2009-04-08 KR KR1020217015136A patent/KR102453184B1/ko active Active
- 2009-04-08 KR KR1020107024935A patent/KR101651695B1/ko active Active
- 2009-04-08 CA CA2720771A patent/CA2720771C/en active Active
- 2009-04-08 KR KR1020187002556A patent/KR101947332B1/ko active Active
- 2009-04-08 KR KR1020167022654A patent/KR101825315B1/ko active Active
- 2009-04-08 EP EP18161023.9A patent/EP3357931B1/en active Active
- 2009-04-08 CA CA3096084A patent/CA3096084C/en active Active
- 2009-04-08 JP JP2011504157A patent/JP5706815B2/ja not_active Expired - Fee Related
- 2009-04-08 WO PCT/US2009/039954 patent/WO2009126737A2/en active Application Filing
- 2009-04-08 KR KR1020207006108A patent/KR102256410B1/ko active Active
- 2009-04-08 AU AU2009233757A patent/AU2009233757B2/en active Active
- 2009-04-08 ES ES18161023T patent/ES2827804T3/es active Active
- 2009-04-08 US US12/420,803 patent/US8283456B2/en active Active
- 2009-04-08 EP EP09731210.2A patent/EP2280987B1/en active Active
- 2009-04-08 KR KR1020197003429A patent/KR102085687B1/ko active Active
- 2009-04-08 CN CN200980116830.8A patent/CN102112484B/zh active Active
2010
- 2010-10-07 IL IL208535A patent/IL208535A/en not_active IP Right Cessation
2012
- 2012-09-13 US US13/613,312 patent/US8889842B2/en active Active
2014
- 2014-09-24 US US14/494,720 patent/US9718850B2/en active Active
2015
- 2015-02-27 JP JP2015038239A patent/JP2015134793A/ja not_active Withdrawn
- 2015-03-02 IL IL237505A patent/IL237505A/en active IP Right Grant
- 2015-05-28 IL IL239051A patent/IL239051B/en active IP Right Grant
- 2015-12-17 HK HK15112457.4A patent/HK1211591A1/xx unknown
2017
- 2017-02-03 JP JP2017018192A patent/JP6786410B2/ja active Active
- 2017-06-16 US US15/626,046 patent/US11447515B2/en active Active
2019
- 2019-01-07 JP JP2019000534A patent/JP6770596B2/ja active Active
2020
- 2020-07-08 JP JP2020117691A patent/JP2020169206A/ja active Pending
2021
- 2021-03-04 IL IL281261A patent/IL281261B2/en unknown
2022
- 2022-09-19 US US17/947,716 patent/US12227535B2/en active Active

Also Published As

Publication number	Publication date
KR20210062717A (ko)	2021-05-31
IL281261A (en)	2021-04-29
KR101825315B1 (ko)	2018-02-02
CA3096084A1 (en)	2009-10-15
CA2720771A1 (en)	2009-10-15
US12227535B2 (en)	2025-02-18
US8889842B2 (en)	2014-11-18
AU2009233757B2 (en)	2015-05-07
KR20190016595A (ko)	2019-02-18
ES2827804T3 (es)	2021-05-24
CN102112484B (zh)	2015-03-04
CN102112484A (zh)	2011-06-29
EP2280987B1 (en)	2018-05-23
CA2993582C (en)	2020-12-15
JP5706815B2 (ja)	2015-04-22
JP2020169206A (ja)	2020-10-15
US20110300177A1 (en)	2011-12-08
CA2993582A1 (en)	2009-10-15
IL237505A0 (en)	2015-04-30
WO2009126737A3 (en)	2010-01-14
KR102256410B1 (ko)	2021-05-26
US20170283450A1 (en)	2017-10-05
US8283456B2 (en)	2012-10-09
US20150086585A1 (en)	2015-03-26
WO2009126737A2 (en)	2009-10-15
EP3357931B1 (en)	2020-07-22
JP6770596B2 (ja)	2020-10-14
EP3357931A1 (en)	2018-08-08
CA2720771C (en)	2018-03-20
KR20200024964A (ko)	2020-03-09
KR102453184B1 (ko)	2022-10-07
CA3096084C (en)	2022-12-20
IL281261B2 (en)	2023-03-01
KR102085687B1 (ko)	2020-03-06
JP2019073530A (ja)	2019-05-16
AU2009233757A1 (en)	2009-10-15
JP2011516566A (ja)	2011-05-26
US20130011421A1 (en)	2013-01-10
EP3868771A1 (en)	2021-08-25
IL281261B (en)	2022-11-01
JP2017114876A (ja)	2017-06-29
IL237505A (en)	2017-06-29
KR20110003523A (ko)	2011-01-12
KR20180014211A (ko)	2018-02-07
IL239051B (en)	2021-03-25
CN104710487A (zh)	2015-06-17
US11447515B2 (en)	2022-09-20
JP6786410B2 (ja)	2020-11-18
IL239051A0 (en)	2015-07-30
IL208535A (en)	2015-06-30
KR101947332B1 (ko)	2019-02-12
US9718850B2 (en)	2017-08-01
KR20160103156A (ko)	2016-08-31
JP2015134793A (ja)	2015-07-27
IL208535A0 (en)	2010-12-30
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US20230131867A1 (en)	2023-04-27

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