HK1211297A1 - 包含至少兩個針對 的重複序列結構域的結合蛋白 - Google Patents
包含至少兩個針對 的重複序列結構域的結合蛋白Info
- Publication number
- HK1211297A1 HK1211297A1 HK15110090.1A HK15110090A HK1211297A1 HK 1211297 A1 HK1211297 A1 HK 1211297A1 HK 15110090 A HK15110090 A HK 15110090A HK 1211297 A1 HK1211297 A1 HK 1211297A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- her2
- binding proteins
- repeat domains
- domains against
- against her2
- Prior art date
Links
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12195156.0A EP2738180A1 (en) | 2012-11-30 | 2012-11-30 | Binding proteins comprising at least two binding domains against HER2. |
| PCT/EP2013/075290 WO2014083208A1 (en) | 2012-11-30 | 2013-12-02 | Binding proteins comprising at least two repeat domains against her2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1211297A1 true HK1211297A1 (zh) | 2016-05-20 |
Family
ID=47257683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15110090.1A HK1211297A1 (zh) | 2012-11-30 | 2015-10-15 | 包含至少兩個針對 的重複序列結構域的結合蛋白 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10370414B2 (zh) |
| EP (2) | EP2738180A1 (zh) |
| JP (1) | JP6410724B2 (zh) |
| KR (1) | KR102290592B1 (zh) |
| CN (1) | CN104918959A (zh) |
| AU (2) | AU2013351096C9 (zh) |
| CA (1) | CA2892747C (zh) |
| HK (1) | HK1211297A1 (zh) |
| MX (1) | MX366223B (zh) |
| RU (1) | RU2664464C9 (zh) |
| WO (1) | WO2014083208A1 (zh) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| BR122020011428B1 (pt) * | 2010-11-26 | 2023-05-16 | Molecular Partners Ag | Proteína de ligação que compreende um domínio de repetição de anquirina e composição farmacêutica |
| JP2015532306A (ja) * | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| WO2014191574A1 (en) | 2013-05-31 | 2014-12-04 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| KR102357906B1 (ko) | 2013-11-27 | 2022-02-03 | 자임워크스 인코포레이티드 | Her2를 표적화하는 이중특이성 항원-결합 작제물 |
| DK3223848T3 (da) | 2014-11-27 | 2025-03-03 | Zymeworks Bc Inc | Fremgangsmåder til anvendelse af bispecifikke antigenbindingskonstrukter målrettet her2 |
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| SG11201707606RA (en) | 2015-04-02 | 2017-10-30 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| US20180273636A1 (en) * | 2015-07-20 | 2018-09-27 | Navigo Proteins Gmbh | Her2 binding proteins based on di-ubiquitin muteins |
| US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
| JP2019526526A (ja) | 2016-05-04 | 2019-09-19 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツングＮａｖｉｇｏ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | ペプチドリンカーを含む化学的部分の部位特異的カップリングのための標的化合物 |
| RU2627215C1 (ru) * | 2016-05-24 | 2017-08-03 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Рекомбинантный таргетный токсин, специфичный к клеткам, экспрессирующим рецептор her2 |
| KR102578256B1 (ko) | 2016-08-11 | 2023-09-15 | 리플리겐 코포레이션 | 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 |
| MX377424B (es) * | 2016-09-22 | 2025-03-10 | Molecular Partners Ag | Proteinas de union recombinantes y sus usos |
| AU2017366739B2 (en) | 2016-12-02 | 2023-11-23 | Angeles Therapeutics, Inc. | Synthetic immune receptors and methods of use thereof |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| CA3139041A1 (en) * | 2019-06-04 | 2020-12-10 | Christian REICHEN | Recombinant 4-1bb binding proteins and their use |
| SG11202112921VA (en) | 2019-06-04 | 2021-12-30 | Molecular Partners Ag | Multispecific proteins |
| MX2021014601A (es) | 2019-06-04 | 2022-02-11 | Molecular Partners Ag | Proteinas recombinantes de union a fap y su uso. |
| CN114206908A (zh) * | 2019-06-04 | 2022-03-18 | 分子伴侣公司 | 具有改善的稳定性的经设计的锚蛋白重复结构域 |
| CN114206941B (zh) | 2019-07-26 | 2024-07-02 | 柳韩洋行 | 抗her2/抗4-1bb双特异性抗体及其用途 |
| CN114929730A (zh) | 2019-12-11 | 2022-08-19 | 分子合作伙伴股份公司 | 重组肽-mhc复合物结合蛋白及其生成和用途 |
| WO2021224686A1 (en) | 2020-05-06 | 2021-11-11 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| US20240279290A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Multispecific proteins |
| US20240108746A1 (en) | 2020-12-16 | 2024-04-04 | Molecular Partners Ag | Novel slow-release prodrugs |
| CA3211381A1 (en) | 2021-03-09 | 2022-09-15 | Matteo Bianchi | Novel darpin based multi-specific t-cell engagers |
| US20240156980A1 (en) | 2021-03-09 | 2024-05-16 | Molecular Partners Ag | Protease cleavable prodrugs |
| CA3211368A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| AU2022231913A1 (en) | 2021-03-09 | 2023-09-28 | Molecular Partners Ag | Novel darpin based cd33 engagers |
| CN118354784A (zh) | 2021-12-14 | 2024-07-16 | 分子合作伙伴股份公司 | 具有双重结合特异性的经设计的重复结构域及其用途 |
| US20240228545A9 (en) | 2022-08-01 | 2024-07-11 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| ES2280131T3 (es) | 1998-12-02 | 2007-09-01 | Adnexus Therapeutics, Inc. | Fusiones de adn-proteina y utilizaciones de las mismas. |
| AU2002218166A1 (en) | 2000-09-08 | 2002-03-22 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| AU2005249396B2 (en) * | 2004-05-05 | 2011-10-20 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents for modulating biological activity |
| KR20120068807A (ko) * | 2004-07-22 | 2012-06-27 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| ES2335136T3 (es) | 2005-07-08 | 2010-03-22 | University Of Zurich | Expresion fagica mediante translocacion cotraduccional de polipeptidos de fusion. |
| EP1996220B2 (en) | 2006-03-06 | 2023-08-16 | Amunix Operating Inc. | Unstructured recombinant polymers and uses thereof |
| US8563521B2 (en) | 2007-06-21 | 2013-10-22 | Technische Universitat Munchen | Biological active proteins having increased in vivo and/or in vitro stability |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| US20110189203A1 (en) | 2007-11-27 | 2011-08-04 | Ablynx N.V. | Immunoglobulin constructs |
| US20100260668A1 (en) | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| CN107011425B (zh) | 2008-11-03 | 2021-01-01 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
| TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| BR122020011428B1 (pt) | 2010-11-26 | 2023-05-16 | Molecular Partners Ag | Proteína de ligação que compreende um domínio de repetição de anquirina e composição farmacêutica |
| EA201391607A1 (ru) | 2011-04-29 | 2014-04-30 | Янссен Байотек, Инк. | Связывающие il4/il13 белки с повторами и их применение |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| AU2013283296A1 (en) | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| JP2015532306A (ja) | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| WO2014191574A1 (en) | 2013-05-31 | 2014-12-04 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
-
2012
- 2012-11-30 EP EP12195156.0A patent/EP2738180A1/en not_active Withdrawn
-
2013
- 2013-12-02 AU AU2013351096A patent/AU2013351096C9/en active Active
- 2013-12-02 RU RU2015120663A patent/RU2664464C9/ru active
- 2013-12-02 KR KR1020157017376A patent/KR102290592B1/ko active Active
- 2013-12-02 JP JP2015544498A patent/JP6410724B2/ja active Active
- 2013-12-02 WO PCT/EP2013/075290 patent/WO2014083208A1/en active Application Filing
- 2013-12-02 EP EP13811818.7A patent/EP2925784B1/en active Active
- 2013-12-02 CN CN201380062520.9A patent/CN104918959A/zh active Pending
- 2013-12-02 US US14/648,611 patent/US10370414B2/en active Active
- 2013-12-02 MX MX2015006548A patent/MX366223B/es active IP Right Grant
- 2013-12-02 CA CA2892747A patent/CA2892747C/en active Active
-
2015
- 2015-10-15 HK HK15110090.1A patent/HK1211297A1/zh unknown
-
2018
- 2018-11-01 AU AU2018256592A patent/AU2018256592A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013351096A1 (en) | 2015-07-09 |
| CA2892747C (en) | 2022-07-19 |
| EP2925784B1 (en) | 2021-02-17 |
| WO2014083208A1 (en) | 2014-06-05 |
| EP2738180A1 (en) | 2014-06-04 |
| MX2015006548A (es) | 2015-10-15 |
| AU2013351096B2 (en) | 2018-08-09 |
| JP6410724B2 (ja) | 2018-10-24 |
| CN104918959A (zh) | 2015-09-16 |
| RU2664464C9 (ru) | 2018-12-19 |
| RU2015120663A (ru) | 2017-01-10 |
| AU2013351096C1 (en) | 2018-11-08 |
| AU2013351096C9 (en) | 2019-01-31 |
| WO2014083208A9 (en) | 2014-12-24 |
| KR20150091138A (ko) | 2015-08-07 |
| US10370414B2 (en) | 2019-08-06 |
| EP2925784A1 (en) | 2015-10-07 |
| RU2664464C2 (ru) | 2018-08-17 |
| WO2014083208A8 (en) | 2014-10-30 |
| US20150299265A1 (en) | 2015-10-22 |
| KR102290592B1 (ko) | 2021-08-19 |
| AU2018256592A1 (en) | 2018-11-22 |
| BR112015012436A2 (pt) | 2017-09-12 |
| JP2015537044A (ja) | 2015-12-24 |
| CA2892747A1 (en) | 2014-06-05 |
| MX366223B (es) | 2019-07-03 |
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