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HK1199286A1 - 作基因重組生產藏紅花化合物的方法和材料 - Google Patents

作基因重組生產藏紅花化合物的方法和材料

Info

Publication number
HK1199286A1
HK1199286A1 HK14112719.9A HK14112719A HK1199286A1 HK 1199286 A1 HK1199286 A1 HK 1199286A1 HK 14112719 A HK14112719 A HK 14112719A HK 1199286 A1 HK1199286 A1 HK 1199286A1
Authority
HK
Hong Kong
Prior art keywords
materials
methods
recombinant production
saffron compounds
saffron
Prior art date
Application number
HK14112719.9A
Other languages
English (en)
Inventor
Shailendra Sonkar
Sathish Kumar
Murali Panchapagesa
Esben Halkjaer Hansen
Klavs Riishede Hansen
Shriram Raghavan
Jorgen Hansen
Kalyan K Kumar
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of HK1199286A1 publication Critical patent/HK1199286A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C12R2001/865—Saccharomyces cerevisiae

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cell Biology (AREA)
HK14112719.9A 2011-08-08 2014-12-18 作基因重組生產藏紅花化合物的方法和材料 HK1199286A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161521171P 2011-08-08 2011-08-08
US201161576460P 2011-12-16 2011-12-16
US201261595450P 2012-02-06 2012-02-06

Publications (1)

Publication Number Publication Date
HK1199286A1 true HK1199286A1 (zh) 2015-06-26

Family

ID=46970359

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112719.9A HK1199286A1 (zh) 2011-08-08 2014-12-18 作基因重組生產藏紅花化合物的方法和材料

Country Status (12)

Country Link
US (2) US20140248668A1 (zh)
EP (1) EP2742131B1 (zh)
JP (1) JP6126597B2 (zh)
KR (2) KR101815063B1 (zh)
CN (1) CN103764818B (zh)
AU (1) AU2012293402B2 (zh)
BR (1) BR112014002924A2 (zh)
CA (1) CA2843549A1 (zh)
HK (1) HK1199286A1 (zh)
IN (1) IN2014CN01129A (zh)
RU (1) RU2676730C2 (zh)
WO (1) WO2013021261A2 (zh)

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EP3892728A1 (en) 2013-02-06 2021-10-13 Evolva SA Methods for improved production of rebaudioside d and rebaudioside m
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
WO2015132411A2 (en) * 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
EP3134539A1 (en) * 2014-04-25 2017-03-01 Evolva SA Methods for recombinant production of saffron compounds
CN111500599A (zh) * 2014-05-16 2020-08-07 中央研究院 用以制备虾红素的重组多核苷酸序列及其应用
SG11201700542XA (en) 2014-07-23 2017-02-27 Enea Ente Nuove Tec A carotenoid dioxygenase and methods for the biotechnological production in microorganisms and plants of compounds derived from saffron
CN106572688B (zh) 2014-08-11 2022-01-25 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
SG11201701677UA (en) * 2014-09-09 2017-04-27 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3250686A1 (en) 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
CN115851470A (zh) 2015-03-16 2023-03-28 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
EP3332018B1 (en) 2015-08-07 2022-07-27 Evolva SA Production of steviol glycosides in recombinant hosts
CN108472279A (zh) 2016-01-07 2018-08-31 科纳根公司 通过生物合成方法制造辣椒酯类物质的方法
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
CN105950493B (zh) * 2016-05-25 2019-12-27 天津大学 一种工程菌及其构建方法与在制备藏红花酸中的应用
CN105950580B (zh) * 2016-05-25 2019-03-08 新疆农业科学院经济作物研究所 一种制备蛋白质UGTCs4的方法
CN105779406B (zh) * 2016-05-25 2019-06-18 新疆农业科学院经济作物研究所 一种藏红花酸糖基转移酶及其编码基因与应用
PL3487986T3 (pl) * 2016-07-19 2021-11-08 Conagen Inc. Sposób produkcji mikrobiologicznej określonych naturalnych kapsaicynoidów
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
CN108728477B (zh) * 2017-04-24 2022-02-22 华东理工大学 一种高效的转座突变系统及构建方法
IT201700089843A1 (it) * 2017-08-03 2019-02-03 Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile Geni e metodi per la produzione e compartimentazione biotecnologica di apocarotenoidi ad elevato valore aggiunto
CN110791510A (zh) * 2018-08-02 2020-02-14 中国医学科学院药用植物研究所 一种参与西红花酸合成的乙醛脱氢酶编码基因的筛选鉴定及应用
WO2020093285A1 (zh) * 2018-11-07 2020-05-14 中国医学科学院药用植物研究所 用于生物合成西红花苷的酶基因及其应用
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF MOGROSIDS
CN109943493B (zh) * 2019-04-17 2021-05-18 天津大学 实现通用酶催化功能多样性的突变体菌株及其构建方法
KR102335035B1 (ko) * 2019-09-17 2021-12-06 아주대학교 산학협력단 효소반응을 이용한 크로신-4의 생산방법
EP4151732A1 (en) * 2021-09-15 2023-03-22 Universidad de Castilla-La Mancha Transgenic plants producing high levels of apocarotenoids compounds and uses thereof
CN116083288B (zh) * 2022-11-11 2025-02-18 泸州品创科技有限公司 产2,3-二氢-2,2,6-三甲基苯甲醛的肠膜明串珠菌及其应用
CN118546994B (zh) * 2024-06-18 2025-01-28 华南农业大学 一种在种子胚乳生产藏红花素的转基因育种方法

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Also Published As

Publication number Publication date
KR20140057319A (ko) 2014-05-12
EP2742131B1 (en) 2018-11-28
AU2012293402A2 (en) 2014-03-13
AU2012293402B2 (en) 2017-08-03
CA2843549A1 (en) 2013-02-14
IN2014CN01129A (zh) 2015-04-10
CN103764818A (zh) 2014-04-30
EP2742131A2 (en) 2014-06-18
WO2013021261A2 (en) 2013-02-14
JP2014524246A (ja) 2014-09-22
US20140248668A1 (en) 2014-09-04
US20170306376A1 (en) 2017-10-26
RU2676730C2 (ru) 2019-01-10
BR112014002924A2 (pt) 2018-10-09
KR101815063B1 (ko) 2018-01-05
KR20180004306A (ko) 2018-01-10
AU2012293402A1 (en) 2014-02-06
WO2013021261A3 (en) 2013-05-02
RU2014109010A (ru) 2015-09-20
KR101983115B1 (ko) 2019-05-29
CN103764818B (zh) 2017-05-31
JP6126597B2 (ja) 2017-05-10

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