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HK1173440A1 - 咪唑並嘧啶- -基 -雜芳基酰胺衍生物及其作為 抑制劑的用途 - Google Patents

咪唑並嘧啶- -基 -雜芳基酰胺衍生物及其作為 抑制劑的用途

Info

Publication number
HK1173440A1
HK1173440A1 HK13100592.7A HK13100592A HK1173440A1 HK 1173440 A1 HK1173440 A1 HK 1173440A1 HK 13100592 A HK13100592 A HK 13100592A HK 1173440 A1 HK1173440 A1 HK 1173440A1
Authority
HK
Hong Kong
Prior art keywords
pde10a
imidazopyrimidin
inhibitors
heteroarylamide derivatives
heteroarylamide
Prior art date
Application number
HK13100592.7A
Other languages
English (en)
Inventor
魯本．阿爾瓦雷茨桑切斯
康拉德．輩萊切
亞歷山大．弗洛爾
羅卡．戈比
卡特里．格勒布科茨賓登
馬蒂亞斯．克爾納
貝恩德．庫恩
延斯-烏韋．彼得斯
馬庫斯．魯道夫
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1173440A1 publication Critical patent/HK1173440A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK13100592.7A 2010-03-26 2013-01-15 咪唑並嘧啶- -基 -雜芳基酰胺衍生物及其作為 抑制劑的用途 HK1173440A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10158011 2010-03-26
PCT/EP2011/054385 WO2011117264A1 (en) 2010-03-26 2011-03-23 N-(imidazopyrimidin-7-yl)-heteroarylamide derivatives and their use as pde10a inhibitors

Publications (1)

Publication Number Publication Date
HK1173440A1 true HK1173440A1 (zh) 2013-05-16

Family

ID=43989818

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13100592.7A HK1173440A1 (zh) 2010-03-26 2013-01-15 咪唑並嘧啶- -基 -雜芳基酰胺衍生物及其作為 抑制劑的用途

Country Status (26)

Country Link
US (1) US8410117B2 (zh)
EP (1) EP2552918B1 (zh)
JP (1) JP5764196B2 (zh)
KR (1) KR20130073876A (zh)
CN (1) CN102791714B (zh)
AR (1) AR080785A1 (zh)
AU (1) AU2011231668A1 (zh)
BR (1) BR112012024199A2 (zh)
CA (1) CA2786213A1 (zh)
CL (1) CL2012002497A1 (zh)
CR (1) CR20120443A (zh)
EC (1) ECSP12012174A (zh)
ES (1) ES2478448T3 (zh)
HK (1) HK1173440A1 (zh)
IL (1) IL220932A0 (zh)
MA (1) MA34069B1 (zh)
MX (1) MX2012010880A (zh)
NZ (1) NZ600927A (zh)
PE (1) PE20130382A1 (zh)
PH (1) PH12012501772A1 (zh)
RU (1) RU2562066C2 (zh)
SG (1) SG183824A1 (zh)
TW (1) TWI478924B (zh)
UA (1) UA108640C2 (zh)
WO (1) WO2011117264A1 (zh)
ZA (1) ZA201206257B (zh)

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PL3394033T3 (pl) 2015-12-22 2021-05-31 Incyte Corporation Związki heterocykliczne jako immunomodulatory
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ES2899402T3 (es) 2016-12-22 2022-03-11 Incyte Corp Derivados de piridina como inmunomoduladores
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
HRP20221216T1 (hr) 2016-12-22 2022-12-23 Incyte Corporation Derivati tetrahidro imidazo[4,5-c]piridina kao induktori internalizacije pd-l1
KR102696516B1 (ko) 2016-12-22 2024-08-22 인사이트 코포레이션 면역조절제로서의 벤조옥사졸 유도체
TWI674260B (zh) 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
PL3774791T3 (pl) 2018-03-30 2023-06-05 Incyte Corporation Związki heterocykliczne jako immunomodulatory
LT4219492T (lt) 2018-05-11 2025-03-10 Incyte Corporation Heterocikliniai junginiai kaip imunomoduliatoriai
WO2020094592A1 (en) 2018-11-06 2020-05-14 H. Lundbeck A/S Compounds for treating negative symptoms and cognitive impairments
WO2020094591A1 (en) 2018-11-06 2020-05-14 H. Lundbeck A/S Pde10a inhibitors for treating negative symptoms and cognitive impairments in a patient suffering from schizophrenia
JP2022544189A (ja) 2019-08-09 2022-10-17 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
JP7559059B2 (ja) 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物
CN114929230B (zh) * 2019-10-21 2024-11-29 爱思开生物制药株式会社 咪唑并嘧啶或咪唑并三嗪化合物用于预防、减轻或治疗认知障碍或者用于改善认知功能的用途
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Also Published As

Publication number Publication date
US20110237564A1 (en) 2011-09-29
ECSP12012174A (es) 2012-10-30
AU2011231668A1 (en) 2012-07-19
JP2013523673A (ja) 2013-06-17
JP5764196B2 (ja) 2015-08-12
KR20130073876A (ko) 2013-07-03
TW201136937A (en) 2011-11-01
MA34069B1 (fr) 2013-03-05
US8410117B2 (en) 2013-04-02
CL2012002497A1 (es) 2013-03-22
CN102791714A (zh) 2012-11-21
PH12012501772A1 (en) 2017-07-26
RU2012143794A (ru) 2014-05-10
EP2552918B1 (en) 2014-06-11
NZ600927A (en) 2013-08-30
ES2478448T3 (es) 2014-07-22
CR20120443A (es) 2012-10-11
RU2562066C2 (ru) 2015-09-10
EP2552918A1 (en) 2013-02-06
CN102791714B (zh) 2015-03-25
TWI478924B (zh) 2015-04-01
MX2012010880A (es) 2012-10-15
SG183824A1 (en) 2012-10-30
AR080785A1 (es) 2012-05-09
BR112012024199A2 (pt) 2016-07-05
CA2786213A1 (en) 2011-09-29
ZA201206257B (en) 2013-05-29
WO2011117264A1 (en) 2011-09-29
PE20130382A1 (es) 2013-03-30
IL220932A0 (en) 2012-09-24
UA108640C2 (uk) 2015-05-25

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190327