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HK1142828A1 - Hydrolysable polymeric fmoc-linker - Google Patents

Hydrolysable polymeric fmoc-linker Download PDF

Info

Publication number
HK1142828A1
HK1142828A1 HK10109423.6A HK10109423A HK1142828A1 HK 1142828 A1 HK1142828 A1 HK 1142828A1 HK 10109423 A HK10109423 A HK 10109423A HK 1142828 A1 HK1142828 A1 HK 1142828A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
group
compound
protein
psa
Prior art date
Application number
HK10109423.6A
Other languages
English (en)
Chinese (zh)
Other versions
HK1142828B (en
Inventor
皮特‧图雷切克
于尔根‧西克曼
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of HK1142828A1 publication Critical patent/HK1142828A1/xx
Publication of HK1142828B publication Critical patent/HK1142828B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14Unsaturated ethers
    • C07C43/164Unsaturated ethers containing six-membered aromatic rings
    • C07C43/168Unsaturated ethers containing six-membered aromatic rings containing six-membered aromatic rings and other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HK10109423.6A 2007-06-26 2008-06-25 Hydrolysable polymeric fmoc-linker HK1142828B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93716907P 2007-06-26 2007-06-26
US60/937,169 2007-06-26
US12326308P 2008-04-07 2008-04-07
US61/123,263 2008-04-07
PCT/EP2008/005155 WO2009000522A1 (en) 2007-06-26 2008-06-25 Hydrolysable polymeric fmoc-linker

Publications (2)

Publication Number Publication Date
HK1142828A1 true HK1142828A1 (en) 2010-12-17
HK1142828B HK1142828B (en) 2013-10-11

Family

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Also Published As

Publication number Publication date
WO2009000522A1 (en) 2008-12-31
JP5622569B2 (ja) 2014-11-12
NZ582669A (en) 2011-07-29
ES2644453T3 (es) 2017-11-29
US20100121028A1 (en) 2010-05-13
DK2173383T3 (en) 2017-09-25
CA2690554C (en) 2016-08-16
US20100121034A1 (en) 2010-05-13
US20090005542A1 (en) 2009-01-01
KR101654375B1 (ko) 2016-09-05
JP2010531371A (ja) 2010-09-24
CN101687048B (zh) 2013-02-27
AU2008267360A1 (en) 2008-12-31
EP2173383B1 (en) 2017-08-09
TWI569810B (zh) 2017-02-11
MX2009013682A (es) 2010-08-31
BRPI0813772A2 (pt) 2014-12-30
US8445544B2 (en) 2013-05-21
TW200908996A (en) 2009-03-01
CN101687048A (zh) 2010-03-31
AU2008267360B2 (en) 2013-09-12
AR067627A1 (es) 2009-10-21
EP2173383A1 (en) 2010-04-14
KR20100039854A (ko) 2010-04-16
CA2690554A1 (en) 2008-12-31
US7700551B2 (en) 2010-04-20

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