[go: up one dir, main page]

HK1135383A1 - Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors - Google Patents

Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

Info

Publication number
HK1135383A1
HK1135383A1 HK09112145.0A HK09112145A HK1135383A1 HK 1135383 A1 HK1135383 A1 HK 1135383A1 HK 09112145 A HK09112145 A HK 09112145A HK 1135383 A1 HK1135383 A1 HK 1135383A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
derivatives
phosphodiesterase inhibitors
alkylene alcohols
pyridynyl
Prior art date
Application number
HK09112145.0A
Other languages
English (en)
Inventor
Gabriele Amari
Elisabetta Armani
Eleonora Ghidini
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of HK1135383A1 publication Critical patent/HK1135383A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
HK09112145.0A 2006-07-14 2009-12-24 Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors HK1135383A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06014672 2006-07-14
PCT/EP2007/005982 WO2008006509A1 (en) 2006-07-14 2007-07-06 Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
HK1135383A1 true HK1135383A1 (en) 2010-06-04

Family

ID=38691860

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09112145.0A HK1135383A1 (en) 2006-07-14 2009-12-24 Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

Country Status (10)

Country Link
US (1) US7671066B2 (de)
EP (1) EP2044023B1 (de)
CN (1) CN101490004B (de)
AR (1) AR062074A1 (de)
AT (1) ATE496029T1 (de)
DE (1) DE602007012105D1 (de)
HK (1) HK1135383A1 (de)
PE (1) PE20080552A1 (de)
TW (1) TW200813010A (de)
WO (1) WO2008006509A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022783A1 (de) * 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. 1-Phenyl-2-Pyridinylalkyl-Alkoholderivate als Phosphodiesterasehemmer
EP2070913A1 (de) * 2007-12-14 2009-06-17 CHIESI FARMACEUTICI S.p.A. Ester-Derivate als Phosphodiesterase-Hemmer
EP2110375A1 (de) 2008-04-14 2009-10-21 CHIESI FARMACEUTICI S.p.A. Phosphodiesterase-4-Hemmer der Tertiäraminklasse
EP2216327A1 (de) 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. (1-Phenyl-2-Pyridin-4-yl)ethyl-benzoate als Phosphodiesterasehemmer
AR079545A1 (es) 2009-12-21 2012-02-01 Bayer Cropscience Ag Tienilpiri(mi)dinilazol
DK2560611T3 (en) 2010-04-21 2018-02-26 Chiesi Farm Spa Process for providing particles with reduced electrostatic charges
BR112013002504A2 (pt) 2010-08-03 2016-05-31 Chiesi Farma Spa formulação farmacêutica para administração em aerosol, inalador pressurizado dosimetrado (pmdi), formulação farmacêutica para nebulização, frasco de dose única ou múltiplas e uso de uma formulação
CN102060762B (zh) * 2011-01-28 2013-05-29 海南美大制药有限公司 孟鲁司特化合物及其新制法
CN102617457A (zh) * 2011-01-28 2012-08-01 天津药物研究院 一种制备罗氟司特的新方法
CA2838435A1 (en) 2011-06-06 2012-12-13 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
JP5759305B2 (ja) * 2011-08-19 2015-08-05 キヤノン株式会社 アクセス管理システム、アクセス管理方法、アクセス管理サーバ、連携サーバ、およびプログラム
CN103827088B (zh) * 2011-09-26 2017-10-13 奇斯药制品公司 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物
BR112014009471A2 (pt) * 2011-10-21 2017-04-18 Chiesi Farm Spa compostos, combinação de um composto, composição farmacêutica, uso de um composto, dispositivo e kit
CN102603623A (zh) * 2011-12-26 2012-07-25 北京赛林泰医药技术有限公司 制备高纯度罗氟司特的方法
CN102417449A (zh) * 2012-01-09 2012-04-18 四川蜀中制药有限公司 一种3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法
WO2013131255A1 (en) 2012-03-07 2013-09-12 Scinopharm (Changshu) Pharmaceutical, Ltd. Preparation method of roflumilast
WO2013182451A1 (en) 2012-06-04 2013-12-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
TR201907092T4 (tr) * 2012-12-05 2019-06-21 Chiesi Farm Spa Fosfodiesteraz inhibitörleri olarak 1-fenil-2-piridinil alkil alkol türevleri.
BR112015012949A2 (pt) * 2012-12-05 2017-07-11 Chiesi Farm Spa composto, composição farmaceutica, uso de um composto, dispositivo inalatório e kit
US10366264B2 (en) * 2013-08-09 2019-07-30 Korea Advanced Institute Of Science And Technology System and method for transferring content among devices
US9427376B2 (en) 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
SG10201912852YA (en) * 2013-10-22 2020-02-27 Chiesi Farm Spa Process for the preparation of a pde4 inhibitor
CN103992220B (zh) * 2014-06-05 2015-11-18 山东省医学科学院药物研究所 一种罗氟司特中间体的制备方法
RU2697251C2 (ru) * 2014-06-23 2019-08-13 Лео Фарма А/С Способы получения 1, 3-бензодиоксольных гетероциклических соединений
CN104447245B (zh) * 2014-10-29 2017-06-06 成都森科制药有限公司 罗氟司特中间体、中间体制备方法及罗氟司特的制备方法
CN104447244B (zh) * 2014-10-29 2017-06-06 成都森科制药有限公司 罗氟司特中间体及罗氟司特的制备方法
CN105254559B (zh) * 2015-11-30 2017-07-11 山东罗欣药业集团股份有限公司 一种高纯度罗氟司特的制备方法
WO2017103058A1 (en) 2015-12-18 2017-06-22 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
MX394835B (es) 2017-06-20 2025-03-24 Union Therapeutics As Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.
US20210038575A1 (en) 2017-12-28 2021-02-11 Chiesi Farmaceutici S.P.A. Use of 1-phenyl-2-pyridinyl alkyl alcohol derivatives for treating cystic fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002465A1 (en) * 1992-07-28 1994-02-03 Rhone-Poulenc Rorer Limited INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation

Also Published As

Publication number Publication date
US7671066B2 (en) 2010-03-02
DE602007012105D1 (de) 2011-03-03
WO2008006509A1 (en) 2008-01-17
PE20080552A1 (es) 2008-06-24
AR062074A1 (es) 2008-10-15
TW200813010A (en) 2008-03-16
CN101490004B (zh) 2012-01-11
ATE496029T1 (de) 2011-02-15
EP2044023B1 (de) 2011-01-19
CN101490004A (zh) 2009-07-22
US20080015226A1 (en) 2008-01-17
EP2044023A1 (de) 2009-04-08

Similar Documents

Publication Publication Date Title
HK1135383A1 (en) Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors
IL239466A0 (en) History of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
HK1225722A1 (zh) 激酶活性抑製劑
IL194755A0 (en) Pyrimidine derivatives as pi3k inhibitors
HK1119696A1 (en) Pyridopyrimidinone inhibitors of pi3k pi3k
HK1135391A1 (en) Triazole derivatives as kinase inhibitors
ZA200706345B (en) Amino-pyridines as inhibitors of ß-secretase
TWI347321B (en) Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
LT2050749T (lt) Pirimidino darinys, kaip pi3k inhibitorius, ir jo panaudojimas
ZA200808282B (en) Uses of DPP-IV inhibitors
PL2044056T3 (pl) Pochodne pirymidyny jako inhibitory ALK-5
IL190292A0 (en) PYRIDOPYRIMIDINONE INHIBITORS OF P13Ka
HK1151291A1 (en) 2-benzylpyridazinone derivatives as met kinase inhibitors
IL184569A0 (en) Intravenous formulations of pde-5 inhibitors
IL196000A0 (en) 2-arylindole derivatives as npges-i inhibitors
GB0608837D0 (en) Inhibitors of MAP kinase
ZA200809113B (en) Pyrimidine derivatives as p13k inhibitors
GB0608855D0 (en) Inhibitors of MAP kinase enzymes
AP2009004815A0 (en) Inhibitors of phosphodiesterase type-IV
GB0622367D0 (en) Phosphodiesterase inhibitors
GB0616863D0 (en) Deracemisation of secondary alcohols