HK1133886A1 - Substituted aryl-indole compounds and their kynurenine kynuramine-like metabolites as therapeutic agents - Google Patents
Substituted aryl-indole compounds and their kynurenine kynuramine-like metabolites as therapeutic agentsInfo
- Publication number
- HK1133886A1 HK1133886A1 HK10101675.8A HK10101675A HK1133886A1 HK 1133886 A1 HK1133886 A1 HK 1133886A1 HK 10101675 A HK10101675 A HK 10101675A HK 1133886 A1 HK1133886 A1 HK 1133886A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kynuramine
- kynurenine
- metabolites
- substituted aryl
- therapeutic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84864206P | 2006-10-03 | 2006-10-03 | |
PCT/IB2007/004306 WO2008041140A2 (en) | 2006-10-03 | 2007-10-03 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1133886A1 true HK1133886A1 (en) | 2010-04-09 |
Family
ID=39271279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10101675.8A HK1133886A1 (en) | 2006-10-03 | 2010-02-12 | Substituted aryl-indole compounds and their kynurenine kynuramine-like metabolites as therapeutic agents |
Country Status (14)
Country | Link |
---|---|
US (3) | US7622495B2 (en) |
EP (2) | EP2086932B1 (en) |
JP (1) | JP5426386B2 (en) |
CN (1) | CN101528689B (en) |
AR (1) | AR063128A1 (en) |
CL (1) | CL2007002858A1 (en) |
DK (1) | DK2086932T3 (en) |
ES (1) | ES2523026T3 (en) |
HK (1) | HK1133886A1 (en) |
PL (1) | PL2086932T3 (en) |
PT (1) | PT2086932E (en) |
SI (1) | SI2086932T1 (en) |
TW (1) | TWI407954B (en) |
WO (1) | WO2008041140A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2091943B1 (en) | 2006-10-21 | 2013-11-20 | AbbVie Deutschland GmbH & Co KG | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors |
CA2726833C (en) | 2008-06-06 | 2016-03-22 | Pharma Two B Ltd. | Pharmaceutical compositions for treatment of parkinson's disease |
EP2621914B1 (en) | 2010-09-27 | 2016-12-28 | Abbott GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
EP2651404B1 (en) | 2010-12-14 | 2015-10-14 | Electrophoretics Limited | Casein kinase 1delta (ck1delta) inhibitors |
US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
US9580398B2 (en) | 2012-04-02 | 2017-02-28 | The Trustees Of Columbia University In The City Of New York | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders |
WO2014152752A1 (en) * | 2013-03-14 | 2014-09-25 | Vistagen Therapeutics, Inc. | Methods for the synthesis of chiral kynurenine compounds |
JP6664814B2 (en) * | 2014-08-18 | 2020-03-13 | 国立大学法人大阪大学 | New 2-aminobenzoyl derivatives |
AU2015367396C1 (en) * | 2014-12-19 | 2019-05-16 | The University Court Of The University Of Edinburgh | 3-(6-alkoxy-5-chlorobenzo[d]isoxazol-3-yl)propanoic acid useful as kynurenine monooxygenase inhibitors |
JOP20170131B1 (en) * | 2016-06-10 | 2021-08-17 | Lilly Co Eli | 1-trahydropyranylcarbonyl-2,3-dihydro-1h-indole compounds for treating cancer |
CN106362155A (en) * | 2016-10-08 | 2017-02-01 | 无锡汉强医药科技有限公司 | Application of GSK3 inhibitor in preparing medicine for treating Niemann-Pick disease type C |
CN106995828B (en) * | 2017-02-04 | 2020-10-09 | 中国科学院成都生物研究所 | Production of N from Camptotheca acuminata suspension cells1Method for preparing (acetyl) kynuramine |
JPWO2018216705A1 (en) * | 2017-05-23 | 2020-03-26 | 国立大学法人京都大学 | Agent for preventing and / or treating neurodegenerative diseases |
US11712425B2 (en) | 2018-03-14 | 2023-08-01 | Albert Einstein College Of Medicine | Immunoregulatory role of 3-OH-kynurenamine and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870162A (en) | 1954-04-28 | 1959-01-20 | Upjohn Co | Production of certain tryptamines and compounds produced in the process |
JPS5336455B2 (en) | 1973-02-03 | 1978-10-03 | ||
IL79264A0 (en) | 1986-06-27 | 1986-09-30 | Univ Ramot | Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors |
AUPO274596A0 (en) | 1996-10-04 | 1996-10-31 | Armstrong, Stuart Maxwell | Method for the treatment of neurological or neuropsychiatric disorders |
US6410584B1 (en) * | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
JP2000007626A (en) | 1998-06-25 | 2000-01-11 | Taisho Pharmaceut Co Ltd | N-substituted nitroaniline derivatives |
IL138825A (en) | 2000-10-03 | 2006-06-11 | Neurim Pharma 1991 | Pharmaceutical formulations containing derivatives of tryptamine and analogous compounds, and some such novel compounds |
ATE292115T1 (en) * | 2001-09-27 | 2005-04-15 | Hoffmann La Roche | INDOLE DERIVATIVES AS COX-II INHIBITORS |
TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
IL156669A0 (en) | 2003-06-26 | 2004-01-04 | Neurim Pharma 1991 | 2-aminobenzoyl derivatives |
US7834016B2 (en) | 2004-09-22 | 2010-11-16 | Janssen Pharmaceutica Nv | Inhibitors of the interaction between MDM2 and p53 |
-
2007
- 2007-10-01 US US11/865,437 patent/US7622495B2/en not_active Expired - Fee Related
- 2007-10-03 DK DK07859335.7T patent/DK2086932T3/en active
- 2007-10-03 SI SI200731548T patent/SI2086932T1/en unknown
- 2007-10-03 PT PT78593357T patent/PT2086932E/en unknown
- 2007-10-03 TW TW096137075A patent/TWI407954B/en not_active IP Right Cessation
- 2007-10-03 JP JP2009530968A patent/JP5426386B2/en not_active Expired - Fee Related
- 2007-10-03 EP EP07859335.7A patent/EP2086932B1/en not_active Not-in-force
- 2007-10-03 ES ES07859335.7T patent/ES2523026T3/en active Active
- 2007-10-03 CN CN2007800370844A patent/CN101528689B/en not_active Expired - Fee Related
- 2007-10-03 CL CL200702858A patent/CL2007002858A1/en unknown
- 2007-10-03 EP EP13179983.5A patent/EP2664615A1/en not_active Withdrawn
- 2007-10-03 WO PCT/IB2007/004306 patent/WO2008041140A2/en active Application Filing
- 2007-10-03 PL PL07859335T patent/PL2086932T3/en unknown
- 2007-10-03 AR ARP070104396A patent/AR063128A1/en unknown
-
2009
- 2009-11-03 US US12/611,373 patent/US8003702B2/en not_active Expired - Fee Related
-
2010
- 2010-02-12 HK HK10101675.8A patent/HK1133886A1/en not_active IP Right Cessation
-
2011
- 2011-08-03 US US13/197,462 patent/US8236858B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7622495B2 (en) | 2009-11-24 |
JP5426386B2 (en) | 2014-02-26 |
US20080132559A1 (en) | 2008-06-05 |
DK2086932T3 (en) | 2014-11-10 |
PL2086932T3 (en) | 2015-02-27 |
TWI407954B (en) | 2013-09-11 |
CL2007002858A1 (en) | 2008-05-16 |
EP2086932B1 (en) | 2014-08-27 |
US20110319494A1 (en) | 2011-12-29 |
JP2010505816A (en) | 2010-02-25 |
CN101528689A (en) | 2009-09-09 |
AR063128A1 (en) | 2008-12-30 |
US20100048663A1 (en) | 2010-02-25 |
PT2086932E (en) | 2014-11-10 |
EP2086932A2 (en) | 2009-08-12 |
WO2008041140A2 (en) | 2008-04-10 |
CN101528689B (en) | 2013-04-24 |
SI2086932T1 (en) | 2014-12-31 |
ES2523026T3 (en) | 2014-11-20 |
WO2008041140A8 (en) | 2009-07-09 |
WO2008041140A3 (en) | 2008-08-14 |
US8236858B2 (en) | 2012-08-07 |
EP2664615A1 (en) | 2013-11-20 |
TW200824684A (en) | 2008-06-16 |
US8003702B2 (en) | 2011-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHRG | Changes in the register |
Free format text: CORRECTION OF THE NAME OF APPLICANT FROM NEURIM PHARMACEUTICALS (1991) LIMITED TO NEURIM PHARMACEUTICALS (1991) LTD |
|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20191003 |