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HK1097768A1 - Modified pyrimidine glucocorticoid receptor modulators - Google Patents

Modified pyrimidine glucocorticoid receptor modulators

Info

Publication number
HK1097768A1
HK1097768A1 HK07105207.1A HK07105207A HK1097768A1 HK 1097768 A1 HK1097768 A1 HK 1097768A1 HK 07105207 A HK07105207 A HK 07105207A HK 1097768 A1 HK1097768 A1 HK 1097768A1
Authority
HK
Hong Kong
Prior art keywords
receptor modulators
glucocorticoid receptor
modified pyrimidine
pyrimidine glucocorticoid
modified
Prior art date
Application number
HK07105207.1A
Inventor
Robin D Clark
Nicholas C Ray
Karen Williams
Peter H Crackett
Gwen Hickin
David A Clark
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of HK1097768A1 publication Critical patent/HK1097768A1/en

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
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Abstract

The present invention provides a class of modified pyrimidine compounds, compositions and methods of using the compounds as glucocorticoid receptor modulators.
HK07105207.1A 2004-07-02 2007-05-17 Modified pyrimidine glucocorticoid receptor modulators HK1097768A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58501804P 2004-07-02 2004-07-02
PCT/US2005/023675 WO2006014394A1 (en) 2004-07-02 2005-06-29 Modified pyrimidine glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
HK1097768A1 true HK1097768A1 (en) 2007-07-06

Family

ID=35311764

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07105207.1A HK1097768A1 (en) 2004-07-02 2007-05-17 Modified pyrimidine glucocorticoid receptor modulators

Country Status (17)

Country Link
US (2) US7576076B2 (en)
EP (1) EP1778236B1 (en)
JP (1) JP4958774B2 (en)
KR (1) KR101210730B1 (en)
AT (1) ATE473744T1 (en)
AU (1) AU2005270039B2 (en)
CA (1) CA2572544C (en)
CY (1) CY1110828T1 (en)
DE (1) DE602005022319D1 (en)
DK (1) DK1778236T3 (en)
ES (1) ES2348667T3 (en)
HK (1) HK1097768A1 (en)
IL (1) IL180508A0 (en)
NZ (1) NZ552984A (en)
PT (1) PT1778236E (en)
WO (1) WO2006014394A1 (en)
ZA (1) ZA200700616B (en)

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EP3684361A4 (en) 2017-09-20 2021-09-08 Kura Oncology, Inc. SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHOD OF USING
ES2987563T3 (en) * 2018-06-04 2024-11-15 Corcept Therapeutics Inc Glucocorticoid receptor modulators cyclohexenyl pyrimidine
WO2020132023A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
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JP7474869B2 (en) 2020-05-06 2024-04-25 コーセプト セラピューティクス， インコーポレイテッド Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators
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IL180508A0 (en) 2007-06-03

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