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HK1092467A1 - N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- - Google Patents

N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n-

Info

Publication number
HK1092467A1
HK1092467A1 HK06113038.1A HK06113038A HK1092467A1 HK 1092467 A1 HK1092467 A1 HK 1092467A1 HK 06113038 A HK06113038 A HK 06113038A HK 1092467 A1 HK1092467 A1 HK 1092467A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
hydroxamic acid
compounds
pharmaceutical uses
isoindolyl compounds
Prior art date
Application number
HK06113038.1A
Other languages
English (en)
Inventor
Hon-Wah Man
George W Muller
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of HK1092467A1 publication Critical patent/HK1092467A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
HK06113038.1A 2003-03-12 2006-11-28 N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- HK1092467A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45414903P 2003-03-12 2003-03-12
PCT/US2004/007742 WO2004080422A2 (en) 2003-03-12 2004-03-12 N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses

Publications (1)

Publication Number Publication Date
HK1092467A1 true HK1092467A1 (en) 2007-02-09

Family

ID=32990872

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06113038.1A HK1092467A1 (en) 2003-03-12 2006-11-28 N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n-

Country Status (15)

Country Link
US (3) US6911464B2 (de)
EP (1) EP1606256B1 (de)
JP (1) JP4727571B2 (de)
KR (1) KR101138064B1 (de)
AT (1) ATE508114T1 (de)
AU (1) AU2004220456B2 (de)
BR (1) BRPI0408220A (de)
CA (1) CA2518513C (de)
DE (1) DE602004032522D1 (de)
ES (1) ES2362484T3 (de)
HK (1) HK1092467A1 (de)
MX (1) MXPA05009535A (de)
NZ (1) NZ542670A (de)
WO (1) WO2004080422A2 (de)
ZA (1) ZA200507283B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69720735T9 (de) * 1996-08-12 2005-08-25 Celgene Corp. Immunotherapeutische mittel und ihre anwendung in der reduzierung der cytokininwerte
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
NZ570777A (en) 2002-05-17 2009-04-30 Celgene Corp Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
AU2003228509B2 (en) * 2002-10-15 2008-06-26 Celgene Corporation Selective cytokine inhibitory drugs for treating myelodysplastic syndrome
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
AU2003226361B2 (en) * 2002-11-06 2009-01-22 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
BR0316057A (pt) 2002-11-06 2005-09-20 Celgene Corp Métodos de tratar, controlar ou prevenir um câncer especìfico e uma doença associada com angiogênese indesejada e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo e com a terapia de radiação, terapia hormonal, terapia biológica ou imunoterapia em um paciente sofrendo de um câncer especìfico, composição farmacêutica e kit
CN1738614A (zh) * 2002-11-18 2006-02-22 细胞基因公司 包含(－)－3－(3,4－二甲氧基－苯基)－3－(1－氧代－1,3－二氢－异吲哚－2－基)－丙酰胺的组合物及其使用方法
CA2506232A1 (en) * 2002-11-18 2004-06-03 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CA2511843C (en) * 2002-12-30 2012-04-24 Celgene Corporation Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses
CN1784382A (zh) * 2003-03-12 2006-06-07 细胞基因公司 7－氨基－异吲哚基化合物及其药物用途
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
WO2005110085A2 (en) * 2004-04-14 2005-11-24 Celgene Corporation Use of selective cytokine inhibitory drugs in myelodysplastic syndromes
CA2563377A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising pde4 modulators for the treatment and management of pulmonary hypertension
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US8236283B2 (en) * 2005-01-06 2012-08-07 Ge Healthcare As Optical imaging
CA2616409C (en) * 2005-08-08 2015-06-16 Tino Zottola Shared dsl network and deployment method
TW200804347A (en) * 2006-01-10 2008-01-16 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
EP2049120A4 (de) 2006-07-31 2011-09-07 Janssen Pharmaceutica Nv Urotensin-ii-rezeptorantagonisten
FR2915100B1 (fr) * 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxalide pour le traitement des desordres moteurs lies a la maladie de parkinson
PA8782701A1 (es) * 2007-06-07 2009-01-23 Janssen Pharmaceutica Nv Antagonistas del receptor de urotensina ii
BRPI0705396B1 (pt) * 2007-12-12 2021-10-05 Universidade Estadual De Campinas - Unicamp Compostos derivados ftalimídicos
GB0810011D0 (en) * 2008-06-02 2008-07-09 Jackson William P 5-Lipoxygenase inhibitors
EP2326644B1 (de) * 2008-08-02 2012-02-22 Janssen Pharmaceutica N.V. Urotensin-ii-rezeptorantagonisten
PE20151143A1 (es) 2009-02-10 2015-08-07 Celgene Corp Metodos para utilizar y composiciones que comprenden moduladores pde4 para tratamiento, prevencion y control de tuberculosis
KR101913868B1 (ko) 2010-06-15 2018-12-28 셀진 코포레이션 건선의 치료를 위한 바이오마커
US20130203756A1 (en) * 2010-10-29 2013-08-08 Jamie L. Bunda Isoindoline pde10 inhibitors
US20140081659A1 (en) 2012-09-17 2014-03-20 Depuy Orthopaedics, Inc. Systems and methods for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking
WO2015175956A1 (en) 2014-05-16 2015-11-19 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
WO2017070291A1 (en) 2015-10-21 2017-04-27 Celgene Corporation Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris)
CN105294533A (zh) * 2015-12-02 2016-02-03 宋彤云 一种治疗骨病的药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US5605914A (en) 1993-07-02 1997-02-25 Celgene Corporation Imides
GB9514867D0 (en) * 1995-07-20 1995-09-20 British Biotech Pharm Metalloproteinase inhibitors
BR9815895A (pt) 1997-07-31 2001-01-16 Celgene Corp Substituido ácido alcanohidroxamico e método para reduzir nìveis de tnf alfa
US6667316B1 (en) * 1999-11-12 2003-12-23 Celgene Corporation Pharmaceutically active isoindoline derivatives
US6699899B1 (en) * 1999-12-21 2004-03-02 Celgene Corporation Substituted acylhydroxamic acids and method of reducing TNFα levels
WO2002081447A1 (en) * 2001-04-06 2002-10-17 Daewoong Pharmaceutical Co., Ltd. 3-cyclopentyloxy-4-methoxyphenyl-isothiazolinone derivatives and the use thereof
CN1784382A (zh) * 2003-03-12 2006-06-07 细胞基因公司 7－氨基－异吲哚基化合物及其药物用途

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JP2006519850A (ja) 2006-08-31
US20040259873A1 (en) 2004-12-23
EP1606256A2 (de) 2005-12-21
EP1606256B1 (de) 2011-05-04
WO2004080422A2 (en) 2004-09-23
US8076369B2 (en) 2011-12-13
WO2004080422A3 (en) 2004-10-28
AU2004220456A1 (en) 2004-09-23
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US20050203090A1 (en) 2005-09-15
US20100267800A1 (en) 2010-10-21
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US7662847B2 (en) 2010-02-16
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US6911464B2 (en) 2005-06-28
MXPA05009535A (es) 2005-11-16

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