HK1080836A1 - Isoquinoline derivatives - Google Patents

Isoquinoline derivatives

Info

Publication number: HK1080836A1
Authority: HK; Hong Kong
Prior art keywords: isoquinoline derivatives; isoquinoline; derivatives
Prior art date: 2002-04-26

Application number

HK06100541A

Other languages

English (en)

Inventor

Andrea Cesura

Rosa Maria Rodriguez Sarmiento

Michelangelo Scalone

Andrew William Thomas

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-26

Filing date

2006-01-13

Publication date

2006-05-04

2006-01-13 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-05-04 Publication of HK1080836A1 publication Critical patent/HK1080836A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

HK06100541A 2002-04-26 2006-01-13 Isoquinoline derivatives HK1080836A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02009253		2002-04-26
PCT/EP2003/003845 WO2003091219A1 (en)	2002-04-26	2003-04-14	Isoquinoline derivatives

Publications (1)

Publication Number	Publication Date
HK1080836A1 true HK1080836A1 (en)	2006-05-04

Family

ID=29265896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK06100541A HK1080836A1 (en)	2002-04-26	2006-01-13	Isoquinoline derivatives

Country Status (31)

Country	Link
US (1)	US6818774B2 (ja)
EP (1)	EP1501804B1 (ja)
JP (1)	JP4322685B2 (ja)
KR (1)	KR100681585B1 (ja)
CN (1)	CN1310890C (ja)
AR (1)	AR039651A1 (ja)
AT (1)	ATE440821T1 (ja)
AU (1)	AU2003227614B2 (ja)
BR (1)	BR0309562A (ja)
CA (1)	CA2483461C (ja)
DE (1)	DE60328978D1 (ja)
DK (1)	DK1501804T3 (ja)
ES (1)	ES2329354T3 (ja)
GT (1)	GT200300095A (ja)
HK (1)	HK1080836A1 (ja)
HR (1)	HRP20040952A2 (ja)
IL (1)	IL164677A0 (ja)
MX (1)	MXPA04010537A (ja)
MY (1)	MY133527A (ja)
NO (1)	NO20044571L (ja)
NZ (1)	NZ535885A (ja)
PA (1)	PA8572001A1 (ja)
PE (1)	PE20040594A1 (ja)
PL (1)	PL373697A1 (ja)
PT (1)	PT1501804E (ja)
RU (1)	RU2318812C2 (ja)
SI (1)	SI1501804T1 (ja)
TW (1)	TWI278451B (ja)
UY (1)	UY27786A1 (ja)
WO (1)	WO2003091219A1 (ja)
ZA (1)	ZA200408281B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004240649A1 (en) *	2003-05-19	2004-12-02	Irm, Llc	Immunosuppressant compounds and compositions
MY150088A (en)	2003-05-19	2013-11-29	Irm Llc	Immunosuppressant compounds and compositions
BRPI0410746A (pt) *	2003-05-19	2006-06-27	Irm Llc	compostos e composições imunossupressoras
CN101407471A (zh)	2003-08-29	2009-04-15	小野药品工业株式会社	能够结合s1p受体的化合物及其药物用途
EP1661881B1 (en)	2003-08-29	2014-12-17	Ono Pharmaceutical Co., Ltd.	Compound capable of binding s1p receptor and pharmaceutical use thereof
CA2543287A1 (en) *	2003-10-23	2005-05-06	F.Hoffmann-La Roche Ag	Benzazepine derivatives as mao-b inhibitors
EP1751111B1 (en)	2004-03-01	2014-12-31	Actelion Pharmaceuticals Ltd.	Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
PT1826197E (pt)	2004-12-13	2012-03-06	Ono Pharmaceutical Co	Derivado de ácido aminocarboxílico e sua utilização medicinal
EP1844033B1 (de) *	2005-01-28	2011-07-27	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur herstellung von isochroman und derivaten davon
AU2006218193A1 (en)	2005-02-25	2006-08-31	F. Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
WO2007071311A1 (en)	2005-12-22	2007-06-28	Newron Pharmaceuticals S.P.A.	2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
CA2644010A1 (en) *	2006-03-15	2007-09-20	Actelion Pharmaceuticals Ltd	Tetrahydroisoquinoline derivatives to enhance memory function
CA2647077A1 (en)	2006-04-26	2007-11-01	Actelion Pharmaceuticals Ltd	Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
KR101220182B1 (ko) *	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CN105315204B (zh) *	2014-07-04	2018-02-09	中南大学	7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途
CN105461626B (zh) *	2015-12-17	2018-05-08	浙江工业大学	芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用
CN105585527B (zh) *	2015-12-17	2018-06-26	浙江工业大学	2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用
US11046675B2 (en) *	2017-03-27	2021-06-29	Bristol-Myers Squibb Company	Substituted isoquionline derivatives as immunomudulators
CN114591238B (zh) *	2022-03-25	2022-11-15	邦恩泰(山东)生物医药科技集团股份有限公司	一种异喹啉类药物中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6137002A (en) *	1993-07-22	2000-10-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
IL110172A (en) *	1993-07-22	2001-10-31	Lilly Co Eli	Bicycle compounds and pharmaceuticals containing them
US6448269B1 (en) *	1993-07-22	2002-09-10	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
US5731324A (en) *	1993-07-22	1998-03-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
US5679715A (en)	1995-06-07	1997-10-21	Harris; Richard Y.	Method for treating multiple sclerosis
CN1116870C (zh)	1996-03-15	2003-08-06	萨默塞特药品有限公司	司立吉林在制备用于预防或治疗外周神经病的药物中的应用
WO2001034172A2 (en)	1999-11-05	2001-05-17	Vela Pharmaceuticals Inc.	Methods and compositions for treating reward deficiency syndrome

2003
- 2003-04-14 DE DE60328978T patent/DE60328978D1/de not_active Expired - Lifetime
- 2003-04-14 RU RU2004134575/04A patent/RU2318812C2/ru not_active IP Right Cessation
- 2003-04-14 JP JP2003587782A patent/JP4322685B2/ja not_active Expired - Fee Related
- 2003-04-14 BR BR0309562-2A patent/BR0309562A/pt not_active IP Right Cessation
- 2003-04-14 AT AT03725018T patent/ATE440821T1/de not_active IP Right Cessation
- 2003-04-14 DK DK03725018T patent/DK1501804T3/da active
- 2003-04-14 CN CNB038093766A patent/CN1310890C/zh not_active Expired - Fee Related
- 2003-04-14 PT PT03725018T patent/PT1501804E/pt unknown
- 2003-04-14 NZ NZ535885A patent/NZ535885A/en not_active IP Right Cessation
- 2003-04-14 WO PCT/EP2003/003845 patent/WO2003091219A1/en active Application Filing
- 2003-04-14 ES ES03725018T patent/ES2329354T3/es not_active Expired - Lifetime
- 2003-04-14 MX MXPA04010537A patent/MXPA04010537A/es active IP Right Grant
- 2003-04-14 SI SI200331658T patent/SI1501804T1/sl unknown
- 2003-04-14 KR KR1020047017185A patent/KR100681585B1/ko not_active IP Right Cessation
- 2003-04-14 AU AU2003227614A patent/AU2003227614B2/en not_active Ceased
- 2003-04-14 EP EP03725018A patent/EP1501804B1/en not_active Expired - Lifetime
- 2003-04-14 PL PL03373697A patent/PL373697A1/xx unknown
- 2003-04-14 CA CA2483461A patent/CA2483461C/en not_active Expired - Fee Related
- 2003-04-16 US US10/417,378 patent/US6818774B2/en not_active Expired - Fee Related
- 2003-04-23 PA PA20038572001A patent/PA8572001A1/es unknown
- 2003-04-23 TW TW092109478A patent/TWI278451B/zh not_active IP Right Cessation
- 2003-04-24 PE PE2003000408A patent/PE20040594A1/es not_active Application Discontinuation
- 2003-04-24 GT GT200300095A patent/GT200300095A/es unknown
- 2003-04-24 AR ARP030101412A patent/AR039651A1/es unknown
- 2003-04-25 MY MYPI20031578A patent/MY133527A/en unknown
- 2003-04-28 UY UY27786A patent/UY27786A1/es not_active Application Discontinuation
2004
- 2004-10-12 HR HR20040952A patent/HRP20040952A2/hr not_active Application Discontinuation
- 2004-10-13 ZA ZA200408281A patent/ZA200408281B/xx unknown
- 2004-10-18 IL IL16467704A patent/IL164677A0/xx not_active IP Right Cessation
- 2004-10-22 NO NO20044571A patent/NO20044571L/no not_active Application Discontinuation
2006
- 2006-01-13 HK HK06100541A patent/HK1080836A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GT200300095A (es)	2004-01-15
JP2005533761A (ja)	2005-11-10
ES2329354T3 (es)	2009-11-25
CA2483461A1 (en)	2003-11-06
JP4322685B2 (ja)	2009-09-02
WO2003091219A1 (en)	2003-11-06
MY133527A (en)	2007-11-30
BR0309562A (pt)	2005-02-15
AR039651A1 (es)	2005-03-02
ATE440821T1 (de)	2009-09-15
KR20040104628A (ko)	2004-12-10
NO20044571L (no)	2004-10-22
EP1501804A1 (en)	2005-02-02
EP1501804B1 (en)	2009-08-26
SI1501804T1 (sl)	2009-12-31
CN1310890C (zh)	2007-04-18
DK1501804T3 (da)	2009-10-12
TWI278451B (en)	2007-04-11
KR100681585B1 (ko)	2007-02-09
DE60328978D1 (de)	2009-10-08
IL164677A0 (en)	2005-12-18
RU2318812C2 (ru)	2008-03-10
PA8572001A1 (es)	2003-12-10
NZ535885A (en)	2007-05-31
MXPA04010537A (es)	2005-01-25
CN1649844A (zh)	2005-08-03
PT1501804E (pt)	2009-10-29
PE20040594A1 (es)	2004-08-30
UY27786A1 (es)	2003-10-31
RU2004134575A (ru)	2005-07-20
CA2483461C (en)	2010-12-21
AU2003227614A1 (en)	2003-11-10
US20030225122A1 (en)	2003-12-04
TW200307670A (en)	2003-12-16
AU2003227614B2 (en)	2008-06-26
ZA200408281B (en)	2005-10-14
HRP20040952A2 (en)	2005-06-30
PL373697A1 (en)	2005-09-05
US6818774B2 (en)	2004-11-16

Publication	Publication Date	Title
HK1080836A1 (en)	2006-05-04	Isoquinoline derivatives
AP1850A (en)	2008-05-26	Spiroindolineplperidine derivatives
EG24050A (en)	2008-04-13	Heterocylocarboxamide derivatives
HK1077068A1 (en)	2006-02-03	Azolidinone-vinyl fused-benzene derivatives
IL166121A0 (en)	2006-01-15	Indole-3-sulphur derivatives
EP1522540A4 (en)	2011-08-10	AZAARENE DERIVATIVES
PL376475A1 (en)	2005-12-27	N-substituted-2-oxodihydropyridine derivatives
HRP20041031A2 (en)	2005-06-30	Quinolinone derivatives
GB0317665D0 (en)	2003-09-03	Qinazoline derivatives
IL166426A0 (en)	2006-01-15	N-biarylmethyl aminocycloalkanecarboxamide derivatives
AU2003227712A1 (en)	2003-12-02	Tetrahydroisoquinoline derivatives
PL376997A1 (pl)	2006-01-23	Pochodne tetrahydrochinoliny
IL165572A0 (en)	2006-01-15	1-Ä(indoÜ-3-yl)carbonylÜpiperazine derivatives
PL377318A1 (pl)	2006-01-23	Pochodne tetrahydrochinoliny
PL371216A1 (en)	2005-06-13	Isoquinoline derivatives
AU2003222659A8 (en)	2003-11-03	23-o-substituted 5-o-mycaminosyltylonide derivatives
EG24415A (en)	2009-05-25	Quinoline derivatives
EP1531854A4 (en)	2006-06-28	O-DERIVATED NOCATHIACIN DERIVATIVES
GB0213488D0 (en)	2002-07-24	2-Naphthamide derivatives
AU2003243397A8 (en)	2003-12-19	Homo-camptothecin derivatives
AU2003290095A8 (en)	2004-07-14	Quinolizidine derivatives
GB0219894D0 (en)	2002-10-02	Dihydropyridinone derivatives
AU2003285777A8 (en)	2004-07-09	3-substituted-4-pyrimidone derivatives
GB0210512D0 (en)	2002-06-19	Tetrahydro-napthalene derivatives
HK1077577A1 (en)	2006-02-17	Tetrahydroquinoline derivatives

Legal Events

Date	Code	Title	Description
2011-12-02	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20110414