HK1079426A1 - Use of ikappab kinase inhibitors for the treatment of pain - Google Patents

Use of ikappab kinase inhibitors for the treatment of pain

Info

Publication number: HK1079426A1
Authority: HK; Hong Kong
Prior art keywords: pain; treatment; kinase inhibitors; ikappab kinase; ikappab
Prior art date: 2002-08-17

Application number

HK05111381.9A

Inventor

Martin Michaelis

Olaf Ritzeler

Gerhard Jaehne

Karl Rudolphi

Gerd Geisslinger

Hans-Georg Schaible

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-17

Filing date

2005-12-12

Publication date

2006-04-07

2005-12-12 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2006-04-07 Publication of HK1079426A1 publication Critical patent/HK1079426A1/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Paper (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HK05111381.9A 2002-08-17 2005-12-12 Use of ikappab kinase inhibitors for the treatment of pain HK1079426A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10237723A DE10237723A1 (en)	2002-08-17	2002-08-17	Use of IKappaB kinase inhibitors in pain therapy
PCT/EP2003/008628 WO2004022057A1 (en)	2002-08-17	2003-08-05	USE OF IκB KINASE INHIBITORS FOR THE TREATMENT OF PAIN

Publications (1)

Publication Number	Publication Date
HK1079426A1 true HK1079426A1 (en)	2006-04-07

Family

ID=31968975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK05111381.9A HK1079426A1 (en)	2002-08-17	2005-12-12	Use of ikappab kinase inhibitors for the treatment of pain

Country Status (34)

Country	Link
EP (1)	EP1531819B1 (en)
JP (1)	JP4504811B2 (en)
KR (2)	KR101119845B1 (en)
CN (1)	CN100398107C (en)
AR (1)	AR043045A1 (en)
AT (1)	ATE418336T1 (en)
AU (1)	AU2003271555B2 (en)
BR (1)	BR0313555A (en)
CA (1)	CA2495455C (en)
CO (1)	CO5690585A2 (en)
CR (1)	CR7716A (en)
CY (1)	CY1108874T1 (en)
DE (2)	DE10237723A1 (en)
DK (1)	DK1531819T3 (en)
EC (1)	ECSP055609A (en)
ES (1)	ES2320118T3 (en)
HK (1)	HK1079426A1 (en)
HR (1)	HRP20050041B1 (en)
IL (1)	IL166780A (en)
MA (1)	MA27334A1 (en)
MX (1)	MXPA05001218A (en)
MY (1)	MY138059A (en)
NO (1)	NO334309B1 (en)
OA (1)	OA12907A (en)
PL (1)	PL212356B1 (en)
PT (1)	PT1531819E (en)
RS (1)	RS51878B (en)
RU (1)	RU2320338C2 (en)
SI (1)	SI1531819T1 (en)
TN (1)	TNSN05044A1 (en)
TW (1)	TWI325782B (en)
UA (1)	UA80837C2 (en)
WO (1)	WO2004022057A1 (en)
ZA (1)	ZA200500323B (en)

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US8022058B2 (en)	2000-05-10	2011-09-20	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en)	2000-05-10	2008-07-01	The Trustees Of Columbia University In The City Of New York	Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7879840B2 (en)	2005-08-25	2011-02-01	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en)	2004-01-22	2010-05-18	The Trustees Of Columbia University In The City Of New York	Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
DE10237722A1 (en) *	2002-08-17	2004-08-19	Aventis Pharma Deutschland Gmbh	Indole or benzimidazole derivatives for the modulation of IKappaB kinase
US7544678B2 (en)	2002-11-05	2009-06-09	The Trustees Of Columbia University In The City Of New York	Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
AU2004220548A1 (en)	2003-03-07	2004-09-23	The Trustees Of Columbia University, In The City Of New York	Type 1 ryanodine receptor-based methods
US8710045B2 (en)	2004-01-22	2014-04-29	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the ryanodine receptors
MX2007000481A (en)	2004-07-14	2007-03-29	Ptc Therapeutics Inc	Methods for treating hepatitis c.
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
JP2008507518A (en)	2004-07-22	2008-03-13	ピーティーシーセラピューティクス，インコーポレーテッド	Thienopyridine for treating hepatitis C
DE102005025225A1 (en) *	2005-06-01	2006-12-07	Sanofi-Aventis Deutschland Gmbh	Process for the preparation of 2- (2-amino-pyrimidin-4-yl) -1H-indole-5-carboxylic acid derivatives
US7704990B2 (en)	2005-08-25	2010-04-27	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the RyR receptors
EP2025674A1 (en)	2007-08-15	2009-02-18	sanofi-aventis	Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
AR072297A1 (en)	2008-06-27	2010-08-18	Novartis Ag	DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
WO2011107494A1 (en)	2010-03-03	2011-09-09	Sanofi	Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
WO2011157827A1 (en)	2010-06-18	2011-12-22	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
JP5790440B2 (en) *	2010-12-01	2015-10-07	住友化学株式会社	Pyrimidine compounds and their use for pest control
EP2683699B1 (en)	2011-03-08	2015-06-24	Sanofi	Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (en)	2011-03-08	2012-09-13	Sanofi	Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120054A1 (en)	2011-03-08	2012-09-13	Sanofi	Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en)	2011-03-08	2014-09-09	Sanofi	Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (en)	2011-03-08	2015-02-18	Sanofi	Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use
EP2532755A1 (en) *	2011-06-10	2012-12-12	Sanofi-Aventis	Methods and uses based on Slfn2 expression and relating to the identification and profiling of compounds for use in the treatment or prevention of pain
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PT2787998T (en)	2011-12-06	2017-01-03	Sanofi Sa	Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
EP3184095A1 (en)	2013-05-23	2017-06-28	IP Gesellschaft für Management mbH	Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
JO3425B1 (en)	2013-07-15	2019-10-20	Novartis Ag	Piperidinyl indole derivatives and their use as complement factor b inhibitors
RU2687094C2 (en) *	2014-07-03	2019-05-07	Санофи	[(s)-1-carbamoyl-2-(phenylpyrimidin-2-ylamino)ethyl]amide 2-(2-methylaminopyrimidin-4-yl)-1h-indole-5-carboxylic acid for use in treating osteoarthritis-related pain
EP3823963A2 (en)	2018-07-16	2021-05-26	Novartis AG	Chemical process for preparing phenylpiperidinyl indole derivatives

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EE04813B1 (en) *	1999-06-23	2007-04-16	Aventis Pharma Deutschland Gmbh	Substituted Benzimidazoles, Their Preparation and their Use in the Preparation of a Drug for the Prophylaxis and Treatment of Diseases Due to Increased NFkB Activity
DE19951360A1 (en) *	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituted indoles
DE10237722A1 (en) *	2002-08-17	2004-08-19	Aventis Pharma Deutschland Gmbh	Indole or benzimidazole derivatives for the modulation of IKappaB kinase

2002
- 2002-08-17 DE DE10237723A patent/DE10237723A1/en not_active Withdrawn
2003
- 2003-05-08 UA UAA200502388A patent/UA80837C2/en unknown
- 2003-08-05 DK DK03753349T patent/DK1531819T3/en active
- 2003-08-05 ES ES03753349T patent/ES2320118T3/en not_active Expired - Lifetime
- 2003-08-05 SI SI200331531T patent/SI1531819T1/en unknown
- 2003-08-05 RS YU20050070A patent/RS51878B/en unknown
- 2003-08-05 DE DE50310980T patent/DE50310980D1/en not_active Expired - Lifetime
- 2003-08-05 AU AU2003271555A patent/AU2003271555B2/en not_active Ceased
- 2003-08-05 MX MXPA05001218A patent/MXPA05001218A/en active IP Right Grant
- 2003-08-05 EP EP03753349A patent/EP1531819B1/en not_active Expired - Lifetime
- 2003-08-05 CN CNB038195429A patent/CN100398107C/en not_active Expired - Fee Related
- 2003-08-05 OA OA1200500046A patent/OA12907A/en unknown
- 2003-08-05 JP JP2004533318A patent/JP4504811B2/en not_active Expired - Fee Related
- 2003-08-05 WO PCT/EP2003/008628 patent/WO2004022057A1/en active Application Filing
- 2003-08-05 KR KR1020057002712A patent/KR101119845B1/en not_active IP Right Cessation
- 2003-08-05 KR KR1020117028345A patent/KR20110135428A/en not_active Application Discontinuation
- 2003-08-05 PL PL373568A patent/PL212356B1/en unknown
- 2003-08-05 PT PT03753349T patent/PT1531819E/en unknown
- 2003-08-05 AT AT03753349T patent/ATE418336T1/en active
- 2003-08-05 RU RU2005107419/15A patent/RU2320338C2/en not_active IP Right Cessation
- 2003-08-05 BR BR0313555-1A patent/BR0313555A/en not_active Application Discontinuation
- 2003-08-05 CA CA2495455A patent/CA2495455C/en not_active Expired - Fee Related
- 2003-08-14 TW TW092122310A patent/TWI325782B/en not_active IP Right Cessation
- 2003-08-14 AR ARP030102944A patent/AR043045A1/en not_active Application Discontinuation
- 2003-08-15 MY MYPI20033112A patent/MY138059A/en unknown
2005
- 2005-01-13 ZA ZA200500323A patent/ZA200500323B/en unknown
- 2005-01-14 HR HRP20050041AA patent/HRP20050041B1/en not_active IP Right Cessation
- 2005-02-09 IL IL166780A patent/IL166780A/en not_active IP Right Cessation
- 2005-02-15 CO CO05013333A patent/CO5690585A2/en not_active Application Discontinuation
- 2005-02-15 MA MA28107A patent/MA27334A1/en unknown
- 2005-02-16 TN TNP2005000044A patent/TNSN05044A1/en unknown
- 2005-02-17 EC EC2005005609A patent/ECSP055609A/en unknown
- 2005-03-07 CR CR7716A patent/CR7716A/en unknown
- 2005-03-15 NO NO20051339A patent/NO334309B1/en not_active IP Right Cessation
- 2005-12-12 HK HK05111381.9A patent/HK1079426A1/en not_active IP Right Cessation
2009
- 2009-03-17 CY CY20091100291T patent/CY1108874T1/en unknown

Also Published As

Publication number	Publication date
WO2004022057A1 (en)	2004-03-18
IL166780A (en)	2011-11-30
KR20110135428A (en)	2011-12-16
RU2005107419A (en)	2005-08-10
CN1674899A (en)	2005-09-28
AU2003271555B2 (en)	2009-03-26
RS51878B (en)	2012-02-29
CY1108874T1 (en)	2014-07-02
BR0313555A (en)	2005-07-12
IL166780A0 (en)	2006-01-15
EP1531819A1 (en)	2005-05-25
JP2005539053A (en)	2005-12-22
MXPA05001218A (en)	2005-05-16
SI1531819T1 (en)	2009-06-30
AR043045A1 (en)	2005-07-13
CR7716A (en)	2008-11-25
ECSP055609A (en)	2005-04-18
CA2495455A1 (en)	2004-03-18
JP4504811B2 (en)	2010-07-14
ZA200500323B (en)	2006-02-22
PT1531819E (en)	2009-02-18
PL212356B1 (en)	2012-09-28
EP1531819B1 (en)	2008-12-24
MY138059A (en)	2009-04-30
AU2003271555A1 (en)	2004-03-29
KR20050058339A (en)	2005-06-16
ATE418336T1 (en)	2009-01-15
TWI325782B (en)	2010-06-11
CN100398107C (en)	2008-07-02
HRP20050041A2 (en)	2006-04-30
TW200417370A (en)	2004-09-16
RU2320338C2 (en)	2008-03-27
HRP20050041B1 (en)	2013-07-31
DE50310980D1 (en)	2009-02-05
CO5690585A2 (en)	2006-10-31
OA12907A (en)	2006-10-13
CA2495455C (en)	2011-01-11
RS20050070A (en)	2007-06-04
TNSN05044A1 (en)	2007-05-14
DK1531819T3 (en)	2009-04-20
NO20051339L (en)	2005-05-03
ES2320118T3 (en)	2009-05-19
PL373568A1 (en)	2005-09-05
UA80837C2 (en)	2007-11-12
MA27334A1 (en)	2005-05-02
KR101119845B1 (en)	2012-02-28
DE10237723A1 (en)	2004-07-08
NO334309B1 (en)	2014-02-03

Publication	Publication Date	Title
HK1079426A1 (en)	2006-04-07	Use of ikappab kinase inhibitors for the treatment of pain
HRP20041029A2 (en)	2004-12-31	Therapeutic use of selcetive pde10 inhibitors
PL374700A1 (en)	2005-10-31	Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
HK1086829A1 (en)	2006-09-29	4-tetrazolyl-4-phenylpiperidine derivatives for treating pain
SI1627639T1 (en)	2010-04-30	Use of COX-2 inhibitors for the treatment of affective disorders
AU2003268424A8 (en)	2004-03-29	Treatment of pain by inhibition of p38 map kinase
HK1083732A1 (en)	2006-07-14	Compounds for the treatment of tobacco dependence and withdrawal
HUP0303236A3 (en)	2012-07-30	Carbamate compounds for use in the treatment of pain
GB0213869D0 (en)	2002-07-31	The treatment of pain
AU2003210983A8 (en)	2003-09-04	Kinase inhibitors and methods of use thereof
HRP20030609A2 (en)	2005-06-30	Use of il-18 inhibitors for the treatment and/or prevention of heart disease
GB0211295D0 (en)	2002-06-26	Treatment of pain
IL162818A0 (en)	2005-11-20	Combination therapy for the treatment of bacterialinfections
AU2003259074A8 (en)	2004-02-25	Gal3 antagonists for the treatment of neuropathic pain
GB2410744B (en)	2006-04-12	Kinase inhibitors for the treatment of disease
IL164951A0 (en)	2005-12-18	The treatment of pain with lfendropil
AU2003264297A1 (en)	2004-04-30	Use of vanilloid receptor antagonists for the treatment of pain
HK1062806A1 (en)	2004-11-26	Novel methods for the treatment and prevention of pain using stress- activated protein kinase inhibitors
HUP0402664A3 (en)	2012-05-29	2-indanylamino derivatives for the therapy of chronic pain
AU2003294697A8 (en)	2004-05-04	Combinations of benzodithiazoles and cox-2 inhibitors for the treatment of pain
IL174968A0 (en)	2008-04-13	The use of ifenprodil in the treatment of pain
GB0325957D0 (en)	2003-12-10	The treatment of pain
GB0216978D0 (en)	2002-08-28	The treatment of pain
GB0213870D0 (en)	2002-07-31	The treatment of pain conditions
SI1487829T1 (en)	2008-02-29	Thiadiazolylpiperazine derivatives useful for treating or preventing pain

Legal Events

Date	Code	Title	Description
2006-05-19	CORR	Corrigendum	Free format text: CORRECTED DATA OF SECTION 20 TO JOURNAL OF 20060407: ¢71! SANOFI-AVENTIS DEUTSCHLAND GMBH - D-65929 FRANKFURT AM MAIN - GERMANY
2017-03-03	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20160805