[go: up one dir, main page]

HK1075001A1 - Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs - Google Patents

Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs

Info

Publication number
HK1075001A1
HK1075001A1 HK05107301.4A HK05107301A HK1075001A1 HK 1075001 A1 HK1075001 A1 HK 1075001A1 HK 05107301 A HK05107301 A HK 05107301A HK 1075001 A1 HK1075001 A1 HK 1075001A1
Authority
HK
Hong Kong
Prior art keywords
ophthalmic
carriers
compositions
nanoparticles
inorganic nanoparticles
Prior art date
Application number
HK05107301.4A
Other languages
English (en)
Inventor
Howard Allen Ketelson
David L Meadows
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of HK1075001A1 publication Critical patent/HK1075001A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
HK05107301.4A 2001-12-21 2005-08-22 Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs HK1075001A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34298301P 2001-12-21 2001-12-21
PCT/US2002/041248 WO2003059194A2 (en) 2001-12-21 2002-12-20 Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs

Publications (1)

Publication Number Publication Date
HK1075001A1 true HK1075001A1 (en) 2005-12-02

Family

ID=23344163

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107301.4A HK1075001A1 (en) 2001-12-21 2005-08-22 Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs

Country Status (19)

Country Link
US (2) US20050003014A1 (de)
EP (1) EP1474109B1 (de)
JP (1) JP2005514429A (de)
KR (1) KR100990810B1 (de)
CN (1) CN100441169C (de)
AT (1) ATE478657T1 (de)
AU (1) AU2002367029B2 (de)
BR (1) BR0215238A (de)
CA (1) CA2467763C (de)
DE (1) DE60237475D1 (de)
DK (1) DK1474109T3 (de)
ES (1) ES2349235T3 (de)
HK (1) HK1075001A1 (de)
MX (1) MXPA04004919A (de)
PL (1) PL211494B1 (de)
PT (1) PT1474109E (de)
SI (1) SI1474109T1 (de)
WO (1) WO2003059194A2 (de)
ZA (1) ZA200403666B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1474109T3 (da) 2001-12-21 2010-10-25 Alcon Inc Anvendelse af syntetiske uorganiske nanopartikler som bærere af ophthalmiske lægemidler
KR20040073503A (ko) * 2001-12-21 2004-08-19 알콘, 인코퍼레이티드 안과용 및 이과용 약제학적 조성물의 점도 및 기타물리학적 성질을 개질시키기 위한 무기 나노입자의 용도
KR100976291B1 (ko) * 2001-12-21 2010-08-16 알콘, 인코퍼레이티드 안과용 조성물중의 살생물제에 대한 담체로서 나노입자의용도
CA2549994A1 (en) 2002-12-18 2004-08-12 Hough Ear Institute Otologic nanotechnology
US7723311B2 (en) 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
US8651113B2 (en) 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
EP2112196A1 (de) * 2008-04-25 2009-10-28 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Flüssige Zusammensetzung mit Polymerketten und Partikeln aus einem anorganischen Material in einer Flüssigkeit
US20100098768A1 (en) * 2008-10-16 2010-04-22 Clarkson University Method of neuroprotection from oxidant injury using metal oxide nanoparticles
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2012074588A2 (en) 2010-08-30 2012-06-07 President And Fellows Of Harvard College Shear controlled release for stenotic lesions and thrombolytic therapies
PT3590949T (pt) 2010-10-01 2022-08-02 Modernatx Inc Ácidos ribonucleicos contendo n1-metilpseudouracilos e suas utilizações
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR20190099538A (ko) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
SG11201402666WA (en) 2011-12-16 2014-10-30 Moderna Therapeutics Inc Modified nucleoside, nucleotide, and nucleic acid compositions
CN104411338A (zh) 2012-04-02 2015-03-11 现代治疗公司 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
EP2847329A4 (de) 2012-04-02 2016-08-10 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von zytoplasma- und zytoskelett-proteinen
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
KR101415221B1 (ko) * 2012-08-07 2014-07-09 한국표준과학연구원 무기 나노입자를 유효성분으로 함유하는 혈관 신생 관련 질환의 예방 및 치료용 조성물
RS63237B1 (sr) 2012-11-26 2022-06-30 Modernatx Inc Terminalno modifikovana rnk
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
EP3041934A1 (de) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimäre polynukleotide
US10323076B2 (en) 2013-10-03 2019-06-18 Modernatx, Inc. Polynucleotides encoding low density lipoprotein receptor
CL2013003807A1 (es) * 2013-12-31 2014-07-11 Univ Santiago Chile Dispositivos de tubos pequeños de silicona que contienen nanopartículas y micropartículas de zeolitas como agentes de liberación prolongada y controlada, cargadas con 2-metoxiestradiol y suspendidas en un medio oleoso que también contiene 2-metoxiestradiol.
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
US20170210788A1 (en) 2014-07-23 2017-07-27 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
EP3179982B1 (de) * 2014-07-28 2023-07-19 Sun Pharma Advanced Research Company Ltd Verfahren zur erhöhung der bioverfügbarkeit und/oder zur verlängerung der ophthalmischen wirkung eines arzneimittels
US11129903B2 (en) 2015-07-06 2021-09-28 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
KR101748120B1 (ko) * 2015-07-13 2017-06-16 서울대학교산학협력단 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
DK3394093T3 (da) 2015-12-23 2022-04-19 Modernatx Inc Fremgangsmåder til anvendelse af ox40-ligand-kodende polynukleotider
EP3400023A1 (de) 2016-01-10 2018-11-14 ModernaTX, Inc. Therapeutische mrnas zur codierung von anti-ctla-4-antikörpern
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
US11077051B2 (en) 2016-09-15 2021-08-03 University of Pittsburgh—of the Commonwealth System of Higher Education Shear-thinning therapeutic composition, and related methods
JP7285220B2 (ja) 2017-05-18 2023-06-01 モデルナティエックス インコーポレイテッド 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
KR102760654B1 (ko) 2017-06-07 2025-02-04 리제너론 파마슈티칼스 인코포레이티드 효소 내재화를 위한 조성물 및 방법
MA51796A (fr) 2018-02-07 2020-12-16 Regeneron Pharma Procédés et compositions pour l'administration de protéines thérapeutiques
CA3097711A1 (en) 2018-04-30 2019-11-07 Regeneron Pharmaceuticals, Inc. Antibodies, and bispecific antigen-binding molecules that bind her2 and/or aplp2, conjugates, and uses thereof
SG11202011232VA (en) 2018-05-17 2020-12-30 Regeneron Pharma Anti-cd63 antibodies, conjugates, and uses thereof
CN109045305B (zh) * 2018-07-31 2021-12-10 东华大学 一种tpgs修饰的锂皂石纳米颗粒的制备方法
EP4491229A2 (de) 2019-02-08 2025-01-15 CureVac SE Codierung von in den suprachoroidalen raum bei der behandlung von augenerkrankungen verabreichter rna
EP3851097A1 (de) * 2020-01-15 2021-07-21 Universidad De Zaragoza Retard-formulierungen
WO2022023559A1 (en) 2020-07-31 2022-02-03 Curevac Ag Nucleic acid encoded antibody mixtures
WO2022059736A1 (ja) 2020-09-17 2022-03-24 株式会社レストアビジョン 小胞体ストレスまたはオールトランスレチナールに関連する疾患、障害または症状を治療または予防するため、または網膜厚を保護し、または網膜厚の萎縮もしくは萎縮進行を抑制するための組成物。
CA3194232A1 (en) 2020-09-29 2022-04-07 Daniel Beard Stroke treatment
US20230220100A1 (en) 2022-01-10 2023-07-13 Regeneron Pharmaceuticals, Inc. Bbb-targeted gaa delivered as gene therapy treats cns and muscle in pompe disease model mice
WO2023220603A1 (en) 2022-05-09 2023-11-16 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
US20240182561A1 (en) 2022-11-04 2024-06-06 Regeneron Pharmaceuticals, Inc. Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
US20240173426A1 (en) 2022-11-14 2024-05-30 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
US20240287186A1 (en) 2023-02-28 2024-08-29 Regeneron Pharmaceuticals, Inc. T cell activators and methods of use thereof
WO2024230934A1 (en) 2023-05-11 2024-11-14 CureVac SE Therapeutic nucleic acid for the treatment of ophthalmic diseases

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US627124A (en) * 1899-06-20 Fan attachment for sewing-machines
US3947573A (en) 1969-12-01 1976-03-30 Burton, Parsons And Company, Inc. Opthalmic solution
US3884826A (en) * 1973-07-20 1975-05-20 Barnes Hind Pharm Inc Thixotropic cleaning agent for hard contact lenses
US3974125A (en) * 1974-09-27 1976-08-10 Exxon Research And Engineering Company Higher dialkyl dimethyl ammonium clay gelling agents for unsaturated polyester compositions
US4127423A (en) * 1977-09-13 1978-11-28 Burton, Parsons And Company, Inc. Contact lens cleaning solution
US4120949A (en) 1977-10-05 1978-10-17 Cooper Laboratories, Inc. Ophthalmic solution
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4394179A (en) * 1979-06-25 1983-07-19 Polymer Technology Corporation Abrasive-containing contact lens cleaning materials
US4374745A (en) * 1981-08-13 1983-02-22 Barnes-Hind Pharmaceuticals, Inc. Cleaning compositions
US4940701A (en) * 1984-01-25 1990-07-10 Beecham Group P.L.C. Topical drug release system
GB8401965D0 (en) * 1984-01-25 1984-02-29 Beecham Group Plc Composition
EP0217440A1 (de) * 1985-09-27 1987-04-08 The Procter & Gamble Company Stabile wässrige pharmazeutische Suspensionen
US4738851A (en) * 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US4804539A (en) * 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
IL80298A (en) 1986-10-14 1993-01-31 Res & Dev Co Ltd Eye drops
WO1988004168A1 (en) * 1986-12-08 1988-06-16 Arseco, Inc. A storage stable topical composition
US4847078A (en) * 1987-01-14 1989-07-11 Arseco, Inc. Storage stable topical composition having moisture control agent
EP0298105A4 (de) 1986-12-24 1989-03-29 Alcon Lab Inc Reinigungsmittel für kontaktlinsen und verfahren zur verwendung.
US4891043A (en) * 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US5037647A (en) * 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
US5674504A (en) * 1989-07-12 1997-10-07 L'oreal Cosmetic composition in the form of an aqueous gel containing in suspension spheroids of a non-hydrophilic, lipoidal substance
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
CA2064160C (en) * 1991-03-27 1998-08-11 Paul J. T. Missel Use of combinations of gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US5212162A (en) * 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
EP0546728A3 (en) * 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
US5139782A (en) * 1991-12-23 1992-08-18 Uop Facial cleansing mineral compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
EP1433477B1 (de) * 1992-07-13 2007-06-27 Shiseido Company, Ltd. Retinolthaltiges, stabilisiertes Hautpflegemittel zur äusserlichen Anwendung
US5532224A (en) * 1993-12-22 1996-07-02 Alcon Laboratories, Inc. Contact lens cleaning composition containing polyalklene oxide modified siloxanes
WO1996003158A1 (en) * 1994-07-22 1996-02-08 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
US5585108A (en) * 1994-12-30 1996-12-17 Nanosystems L.L.C. Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
JP3719609B2 (ja) * 1995-12-21 2005-11-24 アルコン ラボラトリーズ，インコーポレイテッド 緑内障および眼虚血の治療のための特定のイソキノリンスルホニル化合物の使用
JP3736916B2 (ja) 1996-02-19 2006-01-18 株式会社サンコンタクトレンズ 含水性ソフトコンタクトレンズの消毒用組成物とその用途
US6015816A (en) 1996-02-29 2000-01-18 The Research Foundation Of State University Of New York Antimicrobial compositions
CA2266599C (en) * 1996-09-20 2002-03-26 Bausch & Lomb Incorporated Method and composition for rewetting contact lenses and relieving eye dryness
US5811580A (en) * 1996-12-04 1998-09-22 The Lubrizol Corporation Process for the preparation of N-hydrocarbyl-substituted amides via the ritter reaction using solid clay catalysts
CA2272308C (en) * 1996-12-13 2007-01-16 Alcon Laboratories, Inc. Use of low molecular weight amino alcohols in ophthalmic compositions
US5858346A (en) * 1997-05-09 1999-01-12 Allergan Compositions and methods for enhancing contact lens wearability
JP3979783B2 (ja) * 1997-07-29 2007-09-19 アルコン ラボラトリーズ インコーポレイテッド ガラクトマンナンポリマー及びホウ酸塩を含む眼科組成物
ID24946A (id) 1997-11-12 2000-08-31 Bausch & Lomb Perawatan lensa kontak dengan larutan berair yang terdiri dari alkali karbonat
ZA9811445B (en) 1997-12-19 1999-08-16 Alcon Lab Inc Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions.
JPH11281937A (ja) * 1998-03-27 1999-10-15 Menicon Co Ltd コンタクトレンズ用剤
US20010016577A1 (en) * 1998-08-24 2001-08-23 Douglas Joseph Dobrozsi Oral mucoadhesive compositions containing gastrointestinal actives
US6319513B1 (en) * 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
FR2783419B1 (fr) 1998-09-18 2002-07-12 Oreal Utilisation a ph acide de silicates mixtes en tant qu'agents tenseurs dans des compositions cosmetiques anti-rides
ATE276199T1 (de) 1999-02-03 2004-10-15 Biosante Pharmaceuticals Inc Methoden zur herstellung von therapeutische kalzium-phosphat partikeln
US6333054B1 (en) * 1999-10-21 2001-12-25 Amuchina S.P.A. Topical, non-cytotoxic, antimicrobial hydrogel with thixotropic properties
JP2001240547A (ja) * 2000-02-29 2001-09-04 Lion Corp 花粉症抑制剤
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20040076682A1 (en) * 2001-02-15 2004-04-22 Toshiyuki Kohzaki Novel ophthalmic compositions
WO2003011351A2 (en) 2001-08-02 2003-02-13 Johnson & Johnson Vision Care, Inc. Antimicrobial lenses and methods of their use
DK1474109T3 (da) 2001-12-21 2010-10-25 Alcon Inc Anvendelse af syntetiske uorganiske nanopartikler som bærere af ophthalmiske lægemidler
KR20040073503A (ko) * 2001-12-21 2004-08-19 알콘, 인코퍼레이티드 안과용 및 이과용 약제학적 조성물의 점도 및 기타물리학적 성질을 개질시키기 위한 무기 나노입자의 용도
US7217853B2 (en) * 2002-05-24 2007-05-15 Corium International, Inc. Composition for cushions, wound dressings and other skin-contacting products
BR0311585A (pt) * 2002-06-05 2005-05-10 Univ Florida Sistema de fornecimento de drogas, método para administrar uma droga oftálmica a um paciente, kit, uso do mesmo, método para preparar o sistema de fornecimento de drogas, e, artigo de fabricação
US20050181015A1 (en) * 2004-02-12 2005-08-18 Sheng-Ping (Samuel) Zhong Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
US20060193787A1 (en) * 2005-01-31 2006-08-31 Si-Shen Feng Nanoparticle-based drug delivery system

Also Published As

Publication number Publication date
DE60237475D1 (de) 2010-10-07
AU2002367029B2 (en) 2008-10-02
US20050003014A1 (en) 2005-01-06
PL374262A1 (en) 2005-10-03
WO2003059194A2 (en) 2003-07-24
CA2467763A1 (en) 2003-07-24
PT1474109E (pt) 2010-10-25
AU2002367029A1 (en) 2003-07-30
ES2349235T3 (es) 2010-12-29
EP1474109A2 (de) 2004-11-10
ATE478657T1 (de) 2010-09-15
EP1474109B1 (de) 2010-08-25
US8257745B2 (en) 2012-09-04
KR100990810B1 (ko) 2010-10-29
BR0215238A (pt) 2005-05-31
US20110274760A1 (en) 2011-11-10
CN1604770A (zh) 2005-04-06
KR20040072669A (ko) 2004-08-18
EP1474109A4 (de) 2006-03-29
ZA200403666B (en) 2005-07-27
WO2003059194A3 (en) 2004-05-13
CN100441169C (zh) 2008-12-10
MXPA04004919A (es) 2004-08-11
PL211494B1 (pl) 2012-05-31
CA2467763C (en) 2011-09-13
JP2005514429A (ja) 2005-05-19
DK1474109T3 (da) 2010-10-25
SI1474109T1 (sl) 2010-11-30

Similar Documents

Publication Publication Date Title
HK1075001A1 (en) Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs
MXPA04004915A (es) Nanoparticulas inorganicas para modificar la viscosidad y las propiedades fisicas de composiciones oftalmicas y oticas.
MXPA04005227A (es) Uso de nanoparticulas como portadores para biocidas en composiciones oftalmicas.
TW200621268A (en) Antimicrobial copolymers and uses thereof
WO2003054146A3 (en) Self-assembly and mineralization of peptide-amphiphile nanofibers
DE60238358D1 (de) Naturkautschuk-masterbatch dessen Herstellungsverfahren, und Naturkautschukzusammensetzung
DE60232660D1 (de) Humane dr4-antikörper und deren anwendungen
ATE419653T1 (de) Elektrolumineszierende anordnungen
BG64475B1 (bg) Ципразидонови соли
RS51569B (en) COMPOSITIONS CONTAINING CRYSTAL TRANS - (+/-) - DELTA-9-TETRAHYDROCANABINOL
FR2712812B1 (fr) Composition pour la production de produits thérapeutiques in vivo.
MXPA03008401A (es) Combinacion de brimonidina y timolol para uso oftalmico, topico.
TNSN04034A1 (en) Combined preparations, containing 1,4-benzothiepine-1,1-dioxide derivatives and other active substances, and the use thereof
EP1579846A3 (de) Körperpflegemittel
DE60229417D1 (de) Setzungen auf basis von pyrogenisch hergestelltem siliziumdioxid
ATE448769T1 (de) Abgabe von hydrogel-zusammensetzungen aus feinsprühnebel
AU2001266152A1 (en) Novel substituted nitrocatechols, their use in the treatment of some central andperipheral nervous system disorders and pharmaceutical compositions containing them
UA95088C2 (ru) Композиция, которая содержит наночастички связанные с биосовместимым полимером противоракового агента и снижает аллопецию при химиотерапии, способ ее получения
HK1097188A1 (en) Alginate viscoelastic composition, method of use and package
NO20022739D0 (no) Nye terapeutiske kombinasjoner av (S)-2-(benzylamino-metyl)- 2,3,8,9-tetrahydro-7H-1,4-dioksino[2,3-e]indol-8-on ognevroleptika for behandling eller forhindring av psykotiskelidelser
AU7533394A (en) Antiacid pharmaceutical composition in the form of a suspension based on sucralphate gel
JP2002201126A5 (de)
UA67058A (en) Composition for treating periodontitis
SI1757601T1 (sl) Kinolinski derivati in njihova uporaba pri glavkomu in miopiji
DE60029910D1 (de) Gelierzucker zur herstellung von marmeladen

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171220