HK1036062A1 - New cyano-indole serotinin reuptake inhibitor compounds, a process for their preparation and pharmaceutical. - Google Patents

New cyano-indole serotinin reuptake inhibitor compounds, a process for their preparation and pharmaceutical.

Info

Publication number: HK1036062A1
Authority: HK; Hong Kong
Prior art keywords: preparation; cyano; pharmaceutical; indole; reuptake inhibitor
Prior art date: 1999-10-12

Application number

HK01106737A

Other languages

English (en)

Inventor

Gilbert Lavielle

Olivier Muller

Mark Millan

Didier Cussac

Anne Dekeyne

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-12

Filing date

2001-09-25

Publication date

2001-12-21

2001-09-25 Application filed by Servier Lab filed Critical Servier Lab

2001-12-21 Publication of HK1036062A1 publication Critical patent/HK1036062A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HK01106737A 1999-10-12 2001-09-25 New cyano-indole serotinin reuptake inhibitor compounds, a process for their preparation and pharmaceutical. HK1036062A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9912668A FR2799463B1 (fr)	1999-10-12	1999-10-12	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
HK1036062A1 true HK1036062A1 (en)	2001-12-21

Family

ID=9550799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK01106737A HK1036062A1 (en)	1999-10-12	2001-09-25	New cyano-indole serotinin reuptake inhibitor compounds, a process for their preparation and pharmaceutical.

Country Status (23)

Country	Link
US (1)	US6492366B1 (pt)
EP (1)	EP1092715B1 (pt)
JP (1)	JP3274454B2 (pt)
KR (1)	KR100470692B1 (pt)
CN (1)	CN1146568C (pt)
AT (1)	ATE291577T1 (pt)
AU (1)	AU774741B2 (pt)
BR (1)	BR0004764A (pt)
CA (1)	CA2323703C (pt)
DE (1)	DE60018869T2 (pt)
DK (1)	DK1092715T3 (pt)
EA (1)	EA003831B1 (pt)
ES (1)	ES2238260T3 (pt)
FR (1)	FR2799463B1 (pt)
HK (1)	HK1036062A1 (pt)
HU (1)	HUP0003991A2 (pt)
MX (1)	MXPA00009642A (pt)
NO (1)	NO321242B1 (pt)
NZ (1)	NZ507458A (pt)
PL (1)	PL343148A1 (pt)
PT (1)	PT1092715E (pt)
SI (1)	SI1092715T1 (pt)
ZA (1)	ZA200005625B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
US7041683B2 (en)	2001-04-24	2006-05-09	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6559169B2 (en)	2001-04-24	2003-05-06	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7276603B2 (en) *	2003-05-02	2007-10-02	Wyeth	Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2005113833A2 (en) *	2004-05-21	2005-12-01	Duke University	Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis
WO2012054815A1 (en)	2010-10-22	2012-04-26	Duke University	Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2043709C (en) *	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives
JP2575272B2 (ja) *	1990-10-15	1997-01-22	フアイザー・インコーポレイテツド	インドール誘導体
GB9208161D0 (en) *	1992-04-14	1992-05-27	Pfizer Ltd	Indoles
FR2701026B1 (fr) *	1993-02-02	1995-03-31	Adir	Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1271352B (it) *	1993-04-08	1997-05-27	Boehringer Ingelheim Italia	Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
ES2079323B1 (es) *	1994-06-21	1996-10-16	Vita Invest Sa	Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
AU2809295A (en) *	1994-07-11	1996-02-09	Dsm N.V.	Multihydroxy-functional oligophenylene oxide
AR004229A1 (es) *	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US5912256A (en) *	1996-06-20	1999-06-15	Eli Lilly And Company	Compounds having effects on serotonin-related systems
US5998462A (en) *	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds

1999
- 1999-10-12 FR FR9912668A patent/FR2799463B1/fr not_active Expired - Fee Related
2000
- 2000-10-02 MX MXPA00009642A patent/MXPA00009642A/es active IP Right Grant
- 2000-10-10 NO NO20005103A patent/NO321242B1/no unknown
- 2000-10-10 BR BR0004764-3A patent/BR0004764A/pt not_active IP Right Cessation
- 2000-10-11 EP EP00402799A patent/EP1092715B1/fr not_active Expired - Lifetime
- 2000-10-11 DE DE60018869T patent/DE60018869T2/de not_active Expired - Fee Related
- 2000-10-11 SI SI200030652T patent/SI1092715T1/xx unknown
- 2000-10-11 PT PT00402799T patent/PT1092715E/pt unknown
- 2000-10-11 ES ES00402799T patent/ES2238260T3/es not_active Expired - Lifetime
- 2000-10-11 AT AT00402799T patent/ATE291577T1/de not_active IP Right Cessation
- 2000-10-11 EA EA200000929A patent/EA003831B1/ru not_active IP Right Cessation
- 2000-10-11 DK DK00402799T patent/DK1092715T3/da active
- 2000-10-11 NZ NZ507458A patent/NZ507458A/xx unknown
- 2000-10-11 US US09/686,056 patent/US6492366B1/en not_active Expired - Fee Related
- 2000-10-12 AU AU65479/00A patent/AU774741B2/en not_active Ceased
- 2000-10-12 CA CA002323703A patent/CA2323703C/fr not_active Expired - Fee Related
- 2000-10-12 CN CNB001314068A patent/CN1146568C/zh not_active Expired - Fee Related
- 2000-10-12 JP JP2000311550A patent/JP3274454B2/ja not_active Expired - Fee Related
- 2000-10-12 PL PL00343148A patent/PL343148A1/xx not_active Application Discontinuation
- 2000-10-12 HU HU0003991A patent/HUP0003991A2/hu unknown
- 2000-10-12 KR KR10-2000-0060013A patent/KR100470692B1/ko not_active IP Right Cessation
- 2000-10-12 ZA ZA200005625A patent/ZA200005625B/xx unknown
2001
- 2001-09-25 HK HK01106737A patent/HK1036062A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60018869D1 (de)	2005-04-28
KR20010050984A (ko)	2001-06-25
MXPA00009642A (es)	2002-05-23
DK1092715T3 (da)	2005-07-25
NO321242B1 (no)	2006-04-10
NZ507458A (en)	2002-03-28
PL343148A1 (en)	2001-04-23
EP1092715A3 (fr)	2001-08-08
CN1146568C (zh)	2004-04-21
EA200000929A2 (ru)	2001-04-23
ATE291577T1 (de)	2005-04-15
CA2323703C (fr)	2005-08-16
KR100470692B1 (ko)	2005-03-07
EP1092715B1 (fr)	2005-03-23
ZA200005625B (en)	2001-05-02
US6492366B1 (en)	2002-12-10
CA2323703A1 (fr)	2001-04-12
HU0003991D0 (en)	2000-12-28
EA200000929A3 (ru)	2001-06-25
AU6547900A (en)	2001-04-26
BR0004764A (pt)	2001-05-29
PT1092715E (pt)	2005-06-30
EA003831B1 (ru)	2003-10-30
JP2001151772A (ja)	2001-06-05
NO20005103D0 (no)	2000-10-10
FR2799463A1 (fr)	2001-04-13
EP1092715A2 (fr)	2001-04-18
DE60018869T2 (de)	2006-02-02
ES2238260T3 (es)	2005-09-01
NO20005103L (no)	2001-04-17
AU774741B2 (en)	2004-07-08
HUP0003991A2 (en)	2002-06-29
FR2799463B1 (fr)	2004-04-16
SI1092715T1 (en)	2005-06-30
CN1296010A (zh)	2001-05-23
JP3274454B2 (ja)	2002-04-15

Publication	Publication Date	Title
AR058554A1 (es)	2008-02-13	Compuestos heterociclicos nitrogenados de 6 miembros sustituidos, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por mglur5.
PE20011228A1 (es)	2002-01-18	Derivados de piridopirimidina o iminopirimidina utiles para el tratamiento de enfermedades neurodegenerativas
ES549542A0 (es)	1986-04-16	Un procedimiento para preparar nuevos derivados de benzo- triazol- y benzoxazolamina
AR026352A1 (es)	2003-02-05	Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii.
GB1046506A (en)	1966-10-26	Guanidine compounds and process for their manufacture
UY25265A1 (es)	1999-07-19	Procedimiento para la preparacion de acidos 8-alcoxi-quinoloncarboxilicos.
DK1078928T3 (da)	2004-09-13	Pyridinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
HK1036062A1 (en)	2001-12-21	New cyano-indole serotinin reuptake inhibitor compounds, a process for their preparation and pharmaceutical.
PT77231B (en)	1986-02-04	Process for the preparation of 2-nitro-1,1-ethenediamines having a hypotensive effect and their use for the preparation of pharmaceutical compositions with a hypotensive effect
HRP20031055B1 (en)	2008-01-31	Novel immunomodulating compounds
AR038842A1 (es)	2005-01-26	Derivados de artemisinina (endoperoxidos) antiparasitarios
AR026222A1 (es)	2003-01-29	Compuestos derivados de acido antranilico
ES2173175T3 (es)	2002-10-16	Derivado de acido piridonacarboxilico sustituido con un grupo amino biciclico, ester del mismo, sal del mismo, y amina biciclica como intermedio para su preparacion.
DK1101765T3 (da)	2002-12-16	Camptothecin-analoge forbindelser, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
DK1010698T3 (da)	2002-07-22	Hidtil ukendte derivater af 1,2-dithiolan, fremgangsmåde til fremstiling deraf og farmaceutiske sammensætninger indeholdende dem
DK1572198T3 (da)	2006-07-03	Farmaceutiske forbindelser med alfa2-receptoraktivitet
HK1032235A1 (en)	2001-07-13	1-aza-2-alkyl-6-aryl-cycloalkane compounds, a process for their preparation and pharmaceutical compositions containing them
EP0911336A4 (pt)	1999-04-28
AR042004A1 (es)	2005-06-08	Compuestos de fenilnaftaleno ,procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Legal Events

Date	Code	Title	Description
2004-12-15	PF	Patent in force
2009-05-29	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20081012