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HK102492A - A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide - Google Patents

A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide Download PDF

Info

Publication number
HK102492A
HK102492A HK1024/92A HK102492A HK102492A HK 102492 A HK102492 A HK 102492A HK 1024/92 A HK1024/92 A HK 1024/92A HK 102492 A HK102492 A HK 102492A HK 102492 A HK102492 A HK 102492A
Authority
HK
Hong Kong
Prior art keywords
pyrrolidineacetamide
oxo
alpha
ethyl
preparation
Prior art date
Application number
HK1024/92A
Inventor
Cossement Eric
Motte Genevieve
Geerts Jean-Pierre
Gobert Jean
Original Assignee
Ucb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb filed Critical Ucb
Publication of HK102492A publication Critical patent/HK102492A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

S- alpha -Ethyl-2-oxo-1-pyrrolidineacetamide prepared by hydrogenolysis of (S)- alpha - [2-(methylthio)ethyl]-2-oxo-1- pyrrolidineacetamide in the presence of a desulphurizing reagent such as NaBH4/NiCl2.6H2O, Raney nickel W-2 or, preferably, Raney nickel T-1. (S)- alpha -ethyl-2-oxo-1-pyrrolidineacetamide is useful in the treatment and prevention of hypoxic and ischemic type aggressions of the central nervous system.
HK1024/92A 1988-11-23 1992-12-17 A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide HK102492A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827389A GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Publications (1)

Publication Number Publication Date
HK102492A true HK102492A (en) 1992-12-24

Family

ID=10647345

Family Applications (1)

Application Number Title Priority Date Filing Date
HK1024/92A HK102492A (en) 1988-11-23 1992-12-17 A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Country Status (17)

Country Link
KR (1) KR0157610B1 (en)
CN (1) CN1020604C (en)
AT (1) AT392781B (en)
BG (1) BG51041A3 (en)
CY (1) CY1672A (en)
ES (1) ES2023532A6 (en)
FI (1) FI91961C (en)
GB (2) GB8827389D0 (en)
GR (1) GR1000719B (en)
HK (1) HK102492A (en)
HU (1) HU204508B (en)
NO (1) NO173823C (en)
PH (1) PH26332A (en)
PL (1) PL161781B1 (en)
PT (1) PT92365B (en)
RU (1) RU1797607C (en)
SG (1) SG89392G (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319732D0 (en) 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
CA2392879C (en) 1999-12-01 2005-03-29 Ucb, S.A. A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
RU2216322C1 (en) * 2002-02-28 2003-11-20 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Agent eliciting anti-ischemic, hypotensive, anti- -arrhythmic and nootropic activity
WO2004069796A2 (en) * 2003-02-03 2004-08-19 Teva Pharmaceutical Industries Ltd. Process for producing levetiracetam
ES2214147B1 (en) * 2003-02-28 2005-10-01 Farma-Lepori S.A. PROCEDURE FOR OBTAINING AN ANTIEPILEPTIC AGENT.
DK1667967T3 (en) * 2003-09-24 2012-10-08 Ucb Pharma Sa Process for the preparation of 2-oxo-1-pyrrolidine derivatives
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
AU2006254335A1 (en) 2005-06-01 2006-12-07 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
US8338621B2 (en) 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2009050735A1 (en) * 2007-10-15 2009-04-23 Lupin Limited A novel polymorph of levetiracetam and a process for its preparation
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
SMT202100103T1 (en) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv COMBINATION COMPRISING POSITIVE ALLOSTERIC MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 2 AND THEIR USE
HRP20191646T1 (en) 2014-01-21 2019-12-13 Janssen Pharmaceutica Nv COMBINATIONS CONTAINING POSITIVE ALOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition

Also Published As

Publication number Publication date
PL161781B1 (en) 1993-07-30
PT92365B (en) 1995-07-18
NO173823B (en) 1993-11-01
PT92365A (en) 1990-05-31
GB2225322B (en) 1992-03-25
FI91961C (en) 1994-09-12
GB2225322A (en) 1990-05-30
RU1797607C (en) 1993-02-23
CY1672A (en) 1993-05-14
GB8926244D0 (en) 1990-01-10
FI91961B (en) 1994-05-31
CN1042904A (en) 1990-06-13
AT392781B (en) 1991-06-10
ATA266689A (en) 1990-11-15
FI895562A0 (en) 1989-11-22
KR0157610B1 (en) 1998-11-16
HUT53072A (en) 1990-09-28
ES2023532A6 (en) 1992-01-16
BG51041A3 (en) 1993-01-15
HU204508B (en) 1992-01-28
CN1020604C (en) 1993-05-12
NO173823C (en) 1994-02-09
KR900007797A (en) 1990-06-02
NO894649L (en) 1990-05-25
GB8827389D0 (en) 1988-12-29
NO894649D0 (en) 1989-11-22
GR890100769A (en) 1990-12-31
HU896132D0 (en) 1990-02-28
GR1000719B (en) 1992-11-23
SG89392G (en) 1992-12-04
PH26332A (en) 1992-04-29

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20071121