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HK1012283A1 - Process for the preparation of water-soluble camptothecin analogues, as well as the compounds 10-hydroxy-11-c(1-6)-alkoxycamptothecin - Google Patents

Process for the preparation of water-soluble camptothecin analogues, as well as the compounds 10-hydroxy-11-c(1-6)-alkoxycamptothecin Download PDF

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Publication number
HK1012283A1
HK1012283A1 HK98113607A HK98113607A HK1012283A1 HK 1012283 A1 HK1012283 A1 HK 1012283A1 HK 98113607 A HK98113607 A HK 98113607A HK 98113607 A HK98113607 A HK 98113607A HK 1012283 A1 HK1012283 A1 HK 1012283A1
Authority
HK
Hong Kong
Prior art keywords
camptothecin
formula
compound
mixture
alkoxycamptothecin
Prior art date
Application number
HK98113607A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1012283B (en
Inventor
Marian Fortunak Joseph
Lee Wood Jeffery
Rose Mastrocola Antonietta
Mellinger Mark
Lee Burk Patrick
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HK1012283A1 publication Critical patent/HK1012283A1/en
Publication of HK1012283B publication Critical patent/HK1012283B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Steroid Compounds (AREA)
HK98113607.1A 1990-09-28 1991-09-23 Process for the preparation of water-soluble camptothecin analogues, as well as the compounds 10-hydroxy-11-c(1-6)-alkoxycamptothecin HK1012283B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
US589643 1990-09-28
PCT/US1991/006888 WO1992005785A1 (en) 1990-09-28 1991-09-23 Water soluble camptothecin analogues, processes and methods

Publications (2)

Publication Number Publication Date
HK1012283A1 true HK1012283A1 (en) 1999-07-30
HK1012283B HK1012283B (en) 2000-07-21

Family

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Also Published As

Publication number Publication date
HU9300878D0 (en) 1993-06-28
SK283693B6 (sk) 2003-12-02
CN1062731A (zh) 1992-07-15
SK25993A3 (en) 1993-07-07
AU8739991A (en) 1992-04-28
CA2090967C (en) 2007-02-06
HUT70024A (en) 1995-09-28
IL99571A (en) 2000-08-31
YU159991A (sh) 1994-06-10
JPH06501476A (ja) 1994-02-17
ATE186461T1 (de) 1999-11-15
JP2848958B2 (ja) 1999-01-20
NO931153L (no) 1993-03-26
US5734056A (en) 1998-03-31
FI931384A0 (fi) 1993-03-26
IL99571A0 (en) 1992-08-18
DE69131775D1 (de) 1999-12-16
CA2090967A1 (en) 1992-03-29
FI931384A7 (fi) 1993-03-26
CN1033509C (zh) 1996-12-11
PT99109A (pt) 1992-08-31
SI9111599A (sl) 1998-02-28
ES2137932T3 (es) 2000-01-01
AU664830B2 (en) 1995-12-07
FI931384L (fi) 1993-03-26
CZ51593A3 (en) 1994-01-19
ZA917748B (en) 1992-09-30
EP0547165A4 (el) 1994-03-30
GR3031823T3 (en) 2000-02-29
NZ239947A (en) 1994-07-26
WO1992005785A1 (en) 1992-04-16
PT99109B (pt) 1999-02-26
DK0547165T3 (da) 2000-03-27
EP0547165B1 (en) 1999-11-10
IE913402A1 (en) 1992-04-08
DE69131775T2 (de) 2000-04-20
NO931153D0 (no) 1993-03-26
EP0547165A1 (en) 1993-06-23

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Effective date: 20110922