DK0547165T3 - Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc - Google Patents

Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

Info

Publication number: DK0547165T3
Authority: DK; Denmark
Prior art keywords: preparation; compounds; alkoxyc; hydroxy; water
Prior art date: 1990-09-28

Application number

DK91918278T

Other languages

English (en)

Inventor

Joseph Marian Fortunak

Jeffery Lee Wood

Antonietta Rose Mastrocola

Mark Mellinger

Patrick Lee Burk

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-23

Publication date

2000-03-27

1991-09-23 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0547165T3 publication Critical patent/DK0547165T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fodder In General (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Auxiliary Devices For And Details Of Packaging Control (AREA)

DK91918278T 1990-09-28 1991-09-23 Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc DK0547165T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58964390A	1990-09-28	1990-09-28
PCT/US1991/006888 WO1992005785A1 (en)	1990-09-28	1991-09-23	Water soluble camptothecin analogues, processes and methods

Publications (1)

Publication Number	Publication Date
DK0547165T3 true DK0547165T3 (da)	2000-03-27

Family

ID=24358879

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91918278T DK0547165T3 (da)	1990-09-28	1991-09-23	Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

Country Status (25)

Country	Link
US (1)	US5734056A (da)
EP (1)	EP0547165B1 (da)
JP (1)	JP2848958B2 (da)
CN (1)	CN1033509C (da)
AT (1)	ATE186461T1 (da)
AU (1)	AU664830B2 (da)
CA (1)	CA2090967C (da)
CZ (1)	CZ51593A3 (da)
DE (1)	DE69131775T2 (da)
DK (1)	DK0547165T3 (da)
ES (1)	ES2137932T3 (da)
FI (1)	FI931384L (da)
GR (1)	GR3031823T3 (da)
HK (1)	HK1012283A1 (da)
HU (1)	HUT70024A (da)
IE (1)	IE913402A1 (da)
IL (1)	IL99571A (da)
NO (1)	NO931153L (da)
NZ (1)	NZ239947A (da)
PT (1)	PT99109B (da)
SI (1)	SI9111599A (da)
SK (1)	SK283693B6 (da)
WO (1)	WO1992005785A1 (da)
YU (1)	YU159991A (da)
ZA (1)	ZA917748B (da)

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US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
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GB9601779D0 (en) *	1996-01-30	1996-04-03	Pharmacia Spa	9, 10 Disubstituted camptothecin derivatives
US6096336A (en) *	1996-01-30	2000-08-01	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6043367A (en) *	1998-09-30	2000-03-28	Roffler; Steve	Proactive antitumor compounds
US6228855B1 (en)	1999-08-03	2001-05-08	The Stehlin Foundation For Cancer Research	Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en)	1999-08-03	2002-03-05	The Stehlin Foundation For Cancer Research	Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
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ATE375351T1 (de) *	2003-03-31	2007-10-15	Council Scient Ind Res	Verfahren zur herstellung von topotecan aus 10- hydroxy-4-(s) camtothecin
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CZ299329B6 (cs) *	2003-08-26	2008-06-18	Pliva-Lachema A.S.	Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ298934B6 (cs) *	2003-08-26	2008-03-12	Pliva- Lachema A.S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
TWI333492B (en) *	2003-11-12	2010-11-21	Smithkline Beecham Cork Ltd	Crystalline topotecan hydrochloride product and preparation thereof
CZ299593B6 (cs) *	2003-12-16	2008-09-10	Pliva-Lachema A. S.	Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en)	2004-05-28	2005-12-01	Phytogen Life Sciences Inc.	Process to prepare camptothecin derivatives
US20050272757A1 (en) *	2004-06-04	2005-12-08	Phytogen Life Sciences Inc.	Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
JP2008509211A (ja) *	2004-08-09	2008-03-27	シルパ・メディケア・リミテッド	塩酸イリノテカン三水和物の改良された製造方法
EP1824485B1 (en) *	2004-11-05	2012-09-19	Samyang Biopharmaceuticals Corporation	Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
US20060135546A1 (en) *	2004-12-16	2006-06-22	Jagadevappa Basavaraja	Methods for the purification of 20(S)- camptothecin
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KR20080068052A (ko) *	2005-10-10	2008-07-22	씨아이피엘에이 엘티디.	신규의 결정형
US7547785B2 (en)	2005-12-26	2009-06-16	Dr. Reddy's Laboratories Limited	Process for preparing topotecan
EP2023949A4 (en) *	2006-04-26	2009-08-26	Univ California	COMPOSITIONS AND METHODS FOR CONVECTION-REINFORCED RELEASE OF NEUROTHERAPEUTICS WITH HIGH MOLECULAR WEIGHT
PE20080695A1 (es)	2006-04-27	2008-06-28	Banyu Pharma Co Ltd	Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
US20070292883A1 (en) *	2006-06-12	2007-12-20	Ossovskaya Valeria S	Method of treating diseases with PARP inhibitors
US20100279327A1 (en) *	2006-06-12	2010-11-04	Bipar Sciences, Inc.	Method of treating diseases with parp inhibitors
US20080039485A1 (en) *	2006-08-08	2008-02-14	Targetgen Biotechnology Co., Ltd.	Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja)	2006-08-31	2008-04-10	Banyu Pharmaceut Co Ltd	オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
AU2007292387A1 (en) *	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Treatment of cancer
WO2008030891A2 (en) *	2006-09-05	2008-03-13	Bipar Sciences, Inc.	Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
US7977336B2 (en)	2006-12-28	2011-07-12	Banyu Pharmaceutical Co. Ltd	Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en)	2007-04-11	2011-07-12	Scinopharm Taiwan, Ltd.	Process for making topotecan
EP2211854A4 (en) *	2007-10-19	2011-01-12	Bipar Sciences Inc	METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS
EP2213673B1 (en)	2007-10-23	2013-06-05	Msd K.K.	Pyridone-substituted-dihydropyrazolopyrimidinone derivative
EP2217244A4 (en) *	2007-11-12	2011-08-31	Bipar Sciences Inc	TREATMENT OF NUTRITIONAL CANCER AND EGG CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTITUMOROUS MEDICINES
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ITMI20072268A1 (it)	2007-12-04	2009-06-05	Antibioticos Spa	Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
JP2011506343A (ja) *	2007-12-07	2011-03-03	バイパーサイエンシズ，インコーポレイティド	トポイソメラーゼ阻害剤とｐａｒｐ阻害剤との組み合わせによるがんの治療
CN101450949B (zh) *	2007-12-07	2011-10-05	上海龙翔生物医药开发有限公司	一种10-羟基喜树碱的化学半合成工艺
EP2280013B1 (en)	2008-05-29	2013-07-10	MicroBiopharm Japan Co., Ltd.	Production method for camptothecin derivative
JP2012518598A (ja)	2009-02-25	2012-08-16	Ｍｓｄ株式会社	ピリミドピリミドインダゾール誘導体
US8481503B2 (en)	2009-03-06	2013-07-09	Merck Sharp & Dohme Corp.	Combination cancer therapy with an AKT inhibitor and other anticancer agents
JP6013359B2 (ja)	2010-12-17	2016-10-25	ノバルティスアーゲー	組合せ
JP2014504638A (ja)	2011-02-01	2014-02-24	グラクソスミスクラインインテレクチュアルプロパティリミテッド	組合せ
CN103145720B (zh) *	2013-02-20	2015-09-30	上海北卡医药技术有限公司	一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (en) *	2013-12-03	2015-06-10	Synbias Pharma AG	Method for the synthesis of irinotecan
CN115551552A (zh)	2020-02-25	2022-12-30	祐方有限公司	喜树碱衍生物及其缀合物
WO2023220641A2 (en)	2022-05-11	2023-11-16	Juno Therapeutics, Inc.	Methods and uses related to t cell therapy and production of same

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US4473692A (en) *	1981-09-04	1984-09-25	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
JPS595188A (ja) *	1982-06-30	1984-01-12	Yakult Honsha Co Ltd	１０−ヒドロキシカンプトテシンの製造法
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1991
- 1991-09-23 ES ES91918278T patent/ES2137932T3/es not_active Expired - Lifetime
- 1991-09-23 WO PCT/US1991/006888 patent/WO1992005785A1/en active IP Right Grant
- 1991-09-23 AT AT91918278T patent/ATE186461T1/de not_active IP Right Cessation
- 1991-09-23 CZ CS93515A patent/CZ51593A3/cs unknown
- 1991-09-23 JP JP3516992A patent/JP2848958B2/ja not_active Expired - Lifetime
- 1991-09-23 SK SK259-93A patent/SK283693B6/sk not_active IP Right Cessation
- 1991-09-23 DE DE69131775T patent/DE69131775T2/de not_active Expired - Lifetime
- 1991-09-23 DK DK91918278T patent/DK0547165T3/da active
- 1991-09-23 EP EP91918278A patent/EP0547165B1/en not_active Expired - Lifetime
- 1991-09-23 AU AU87399/91A patent/AU664830B2/en not_active Expired
- 1991-09-23 HU HU9300878A patent/HUT70024A/hu unknown
- 1991-09-23 CA CA002090967A patent/CA2090967C/en not_active Expired - Lifetime
- 1991-09-26 IL IL9957191A patent/IL99571A/xx not_active IP Right Cessation
- 1991-09-26 NZ NZ23994791A patent/NZ239947A/en not_active IP Right Cessation
- 1991-09-27 IE IE340291A patent/IE913402A1/en not_active IP Right Cessation
- 1991-09-27 ZA ZA917748A patent/ZA917748B/xx unknown
- 1991-09-27 PT PT99109A patent/PT99109B/pt not_active IP Right Cessation
- 1991-09-28 CN CN91110656A patent/CN1033509C/zh not_active Expired - Lifetime
- 1991-09-30 SI SI9111599A patent/SI9111599A/sl unknown
- 1991-09-30 YU YU159991A patent/YU159991A/sh unknown
1993
- 1993-03-26 NO NO93931153A patent/NO931153L/no unknown
- 1993-03-26 FI FI931384A patent/FI931384L/fi not_active Application Discontinuation
1995
- 1995-05-25 US US08/451,079 patent/US5734056A/en not_active Expired - Lifetime
1998
- 1998-12-16 HK HK98113607A patent/HK1012283A1/xx not_active IP Right Cessation
1999
- 1999-11-11 GR GR990402820T patent/GR3031823T3/el unknown

Also Published As

Publication number	Publication date
PT99109B (pt)	1999-02-26
NO931153D0 (no)	1993-03-26
GR3031823T3 (en)	2000-02-29
AU8739991A (en)	1992-04-28
ES2137932T3 (es)	2000-01-01
SI9111599A (sl)	1998-02-28
CZ51593A3 (en)	1994-01-19
IL99571A (en)	2000-08-31
AU664830B2 (en)	1995-12-07
YU159991A (sh)	1994-06-10
HUT70024A (en)	1995-09-28
FI931384A0 (fi)	1993-03-26
CN1062731A (zh)	1992-07-15
US5734056A (en)	1998-03-31
SK25993A3 (en)	1993-07-07
DE69131775D1 (de)	1999-12-16
IE913402A1 (en)	1992-04-08
IL99571A0 (en)	1992-08-18
FI931384L (fi)	1993-03-26
CN1033509C (zh)	1996-12-11
EP0547165A4 (da)	1994-03-30
HK1012283A1 (en)	1999-07-30
DE69131775T2 (de)	2000-04-20
JP2848958B2 (ja)	1999-01-20
PT99109A (pt)	1992-08-31
NO931153L (no)	1993-03-26
HU9300878D0 (en)	1993-06-28
CA2090967C (en)	2007-02-06
SK283693B6 (sk)	2003-12-02
ATE186461T1 (de)	1999-11-15
EP0547165A1 (en)	1993-06-23
WO1992005785A1 (en)	1992-04-16
CA2090967A1 (en)	1992-03-29
EP0547165B1 (en)	1999-11-10
ZA917748B (en)	1992-09-30
JPH06501476A (ja)	1994-02-17
NZ239947A (en)	1994-07-26

Publication	Publication Date	Title
DK0547165T3 (da)	2000-03-27	Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc
JPS5412381A (en)	1979-01-30	N-alkylpiperidine derivative
ES8207533A1 (es)	1982-10-01	Un procedimiento para la preparacion de derivados de pirazo-lopiridacina
DK161744C (da)	1992-02-17	Fremgangsmaade til fremstilling af fritstroemmende ethylcellulosemikrokapsler
DK155944C (da)	1989-12-04	Analogifremgangsmaade til fremstilling af 7-omega-substitueretethylen(cis)-thio-acetamido)-3-cephem-4-carboxylsyrederivater.
JPS52286A (en)	1977-01-05	Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
BG44203A3 (en)	1988-10-14	Method for preparing of 2- oxyindol- 1- carboxamides
BG35749A3 (en)	1984-06-15	Method for preparing 20- dihydro- 20, 23- dideoxytilonolide
JPS5235227A (en)	1977-03-17	Preparation of filters for adhesives
JPS53132547A (en)	1978-11-18	Novel trisazo compound and its preparation
JPS547427A (en)	1979-01-20	Novel disazo compounds and their preparation
JPS53133229A (en)	1978-11-20	Novel disazo compounds and their preparation
JPS5386094A (en)	1978-07-29	Preparation of 7-amino-cephem derivatives
DK132283A (da)	1983-09-25	Fremgangsmaade til fremstilling af indolizino(8,7-b)indolderivater
JPS5417182A (en)	1979-02-08	Preparation of choline-oxidase
BG35034A3 (en)	1984-01-16	Method for preparing derivatives of 3, 7, 11- trimethyl- 2, 4- dodecadienic acid
JPS51139688A (en)	1976-12-02	Process for preparing new alkaloid tm-64 substance by fermentation
JPS5277093A (en)	1977-06-29	Preparation of condensed quinazoline derivative
JPS53101373A (en)	1978-09-04	Imidazole-4(5)-carboxylic acid anilide derivatives
ES516584A0 (es)	1983-10-16	Mejoras introducidas en un procedimiento para la preparacion de hidroximidatos y tiolhidroximidatos heterobiciclicos y derivados ester carbamato de lso mismos.
JPS5328186A (en)	1978-03-16	Preparation of novel s-triazine compound
JPS5231093A (en)	1977-03-09	Preparation of 3- methylenecephalosporanic acid derivatives
JPS51128988A (en)	1976-11-10	Process for preparing quinazolone compounds
JPS5231030A (en)	1977-03-09	Process for preparation of phosphonitrile derivatives
JPS5269491A (en)	1977-06-09	Preparation of high polymeric selenium compounds