HK1006779A1 - Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists - Google Patents

Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists

Info

Publication number: HK1006779A1
Authority: HK; Hong Kong
Prior art keywords: inhibitors; receptor antagonists; bone resorption; vitronectin receptor; cycloalkyl derivatives
Prior art date: 1996-07-24

Application number

HK98105626A

Other languages

English (en)

Inventor

Volkmar Wehner

Jochen Knolle

Hans Ulrich Stilz

Jean-Francois Gourvest

Denis Carniato

Thomas Richard Gadek

Robert Mcdowell

Robert Maurice Pitti

Sarah Catherine Bodary

Original Assignee

Hoechst Ag

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-24

Filing date

1998-06-18

Publication date

1999-03-19

1998-06-18 Application filed by Hoechst Ag, Genentech Inc filed Critical Hoechst Ag

1999-03-19 Publication of HK1006779A1 publication Critical patent/HK1006779A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HK98105626A 1996-07-24 1998-06-18 Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists HK1006779A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19629816A DE19629816A1 (de)	1996-07-24	1996-07-24	Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

Publications (1)

Publication Number	Publication Date
HK1006779A1 true HK1006779A1 (en)	1999-03-19

Family

ID=7800671

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98105626A HK1006779A1 (en)	1996-07-24	1998-06-18	Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists

Country Status (24)

Country	Link
US (3)	US6399620B1 (no)
EP (1)	EP0820991B1 (no)
JP (1)	JP4077535B2 (no)
KR (1)	KR100541172B1 (no)
CN (1)	CN1064352C (no)
AR (1)	AR007961A1 (no)
AT (1)	ATE371650T1 (no)
AU (1)	AU726376B2 (no)
BR (1)	BR9704072A (no)
CA (1)	CA2211270C (no)
CZ (1)	CZ234397A3 (no)
DE (2)	DE19629816A1 (no)
HK (1)	HK1006779A1 (no)
HR (1)	HRP970404A2 (no)
HU (1)	HUP9701264A3 (no)
ID (1)	ID17615A (no)
IL (1)	IL121359A0 (no)
NO (1)	NO311083B1 (no)
NZ (1)	NZ328388A (no)
PL (1)	PL189189B1 (no)
RU (1)	RU2180331C2 (no)
SK (1)	SK100597A3 (no)
TW (1)	TW490461B (no)
ZA (1)	ZA976532B (no)

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DE19629816A1 (de)	1996-07-24	1998-01-29	Hoechst Ag	Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US6482821B2 (en)	1996-12-20	2002-11-19	Hoechst Aktiengellschaft	Vitronectin receptor antagonists, their preparation and their use
DE19653645A1 (de) *	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
US6218387B1 (en)	1996-12-20	2001-04-17	Hoechst Aktiengesellschaft	Vitronectin receptor anatagonists, their preparation and their use
DE19653647A1 (de) *	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
US6313119B1 (en)	1998-01-23	2001-11-06	Adventis Pharma Deutschland Gmbh	Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion
JP4064059B2 (ja)	1998-04-09	2008-03-19	明治製菓株式会社	インテグリンαＶβ３拮抗剤としてのアミノピペリジン誘導体
BR9910119A (pt) *	1998-04-10	2001-10-09	Searle & Co	Derivados heterocìclicos de glicil beta-alanina como antagonistas de vitronectina
US6689754B1 (en)	1998-04-10	2004-02-10	G. D. Searle & Co.	Heterocyclic glycyl β-alanine derivatives
AU3561099A (en) *	1998-04-14	1999-11-01	American Home Products Corporation	Acylresorcinol derivatives as selective vitronectin receptor inhibitors
EP0960882A1 (en) *	1998-05-19	1999-12-01	Hoechst Marion Roussel Deutschland GmbH	Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
DE19842415A1 (de)	1998-09-16	2000-03-23	Merck Patent Gmbh	Pharmazeutische Zubereitung
FR2786182B1 (fr) *	1998-11-24	2001-01-12	Hoechst Marion Roussel Inc	Nouveaux derives d'acylguanidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2786184B1 (fr) *	1998-11-24	2002-09-20	Hoechst Marion Roussel Inc	Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
JP2002533406A (ja)	1998-12-23	2002-10-08	ジー．ディー．サール＆カンパニー	新生物の治療における併用療法として、金属プロティナーゼ抑制剤および一またはそれ以上の抗新生物剤を用いる方法
EP1028114A1 (en) *	1999-02-13	2000-08-16	Aventis Pharma Deutschland GmbH	Novel guanidine derivatives as inhibitors of cell adhesion
US6455734B1 (en)	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
CA2378860A1 (en) *	1999-07-21	2001-02-01	American Home Products Corporation	Bicyclic antagonists selective for the .alpha.v.beta.3 integrin
JP2003505514A (ja) *	1999-07-28	2003-02-12	ザトラスティーズオブザユニバーシティオブペンシルベニア	破骨細胞生成を阻害する方法
AU6316900A (en)	1999-08-05	2001-03-05	Meiji Seika Kaisha Ltd.	Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism
EP1108721A1 (en) *	1999-12-15	2001-06-20	Aventis Pharma Deutschland GmbH	Thienylalanine derivatives as inhibitors of cell adhesion
FR2808798A1 (fr) *	2000-05-09	2001-11-16	Hoechst Marion Roussel Inc	Nouveaux derives antagonistes du recepteur de la vitronectine
EP1197488A1 (en)	2000-10-10	2002-04-17	Aventis Pharma Deutschland GmbH	(2S)-2-(Adamantan-1-ylmethoxycarbonylamino)-3-(4-(2-(1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propionic acid isopropyl ester, its preparation and its use
KR20040058229A (ko)	2001-10-22	2004-07-03	더 스크립스 리서치 인스티튜트	항체 표적화 화합물
FR2847254B1 (fr) *	2002-11-19	2005-01-28	Aventis Pharma Sa	Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
WO2005092864A1 (en)	2004-03-23	2005-10-06	Pfizer Products Inc.	Imidazole compounds for the treatment of neurodegenerative disorders
FR2870541B1 (fr)	2004-05-18	2006-07-14	Proskelia Sas	Derives de pyrimidines antigonistes du recepteur de la vitronectine
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
KR20080040010A (ko) *	2005-09-22	2008-05-07	화이자 프로덕츠 인코포레이티드	신경계 질환 치료용 이미다졸 화합물
US20070122408A1 (en) *	2005-10-20	2007-05-31	The Scripps Research Institute	Fc Labeling for Immunostaining and Immunotargeting
WO2010093706A2 (en)	2009-02-10	2010-08-19	The Scripps Research Institute	Chemically programmed vaccination
US10328082B2 (en)	2014-05-30	2019-06-25	Pfizer Inc.	Methods of use and combinations
EP3509590A4 (en)	2016-09-07	2020-12-02	Pliant Therapeutics, Inc.	N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

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JPH04367367A (ja)	1991-06-11	1992-12-18	Nkk Corp	ロータリノズル
US5204350A (en) *	1991-08-09	1993-04-20	Merck & Co., Inc.	Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
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DE4207254A1 (de) *	1992-03-07	1993-09-09	Cassella Ag	4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de)	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
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AU675689B2 (en) *	1992-12-01	1997-02-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
DE4427979A1 (de)	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
JPH10501222A (ja) *	1994-05-27	1998-02-03	メルクエンドカンパニーインコーポレーテッド	破骨細胞仲介骨吸収を抑制するための化合物
MX9700041A (es) *	1994-06-29	1997-04-30	Smithkline Beecham Corp	Antagonistas de receptor de vitronectina.
EP0762882A4 (en) *	1994-06-29	2002-09-11	Smithkline Beecham Corp	Vibronectin Receptor Antagonists
DE19548709A1 (de)	1995-12-23	1997-07-03	Merck Patent Gmbh	Tyrosinderivate
DE19629816A1 (de) *	1996-07-24	1998-01-29	Hoechst Ag	Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
DE19629817A1 (de) *	1996-07-24	1998-01-29	Hoechst Ag	Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US6017925A (en)	1997-01-17	2000-01-25	Merck & Co., Inc.	Integrin antagonists
AU729869B2 (en)	1997-01-17	2001-02-15	Merck & Co., Inc.	Integrin antagonists
US6313119B1 (en) *	1998-01-23	2001-11-06	Adventis Pharma Deutschland Gmbh	Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion
FR2786182B1 (fr) *	1998-11-24	2001-01-12	Hoechst Marion Roussel Inc	Nouveaux derives d'acylguanidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP1028114A1 (en) *	1999-02-13	2000-08-16	Aventis Pharma Deutschland GmbH	Novel guanidine derivatives as inhibitors of cell adhesion

1996
- 1996-07-24 DE DE19629816A patent/DE19629816A1/de not_active Withdrawn
1997
- 1997-07-17 AT AT97112198T patent/ATE371650T1/de not_active IP Right Cessation
- 1997-07-17 EP EP97112198A patent/EP0820991B1/de not_active Expired - Lifetime
- 1997-07-17 DE DE59712879T patent/DE59712879D1/de not_active Expired - Lifetime
- 1997-07-22 HU HU9701264A patent/HUP9701264A3/hu unknown
- 1997-07-22 AR ARP970103298A patent/AR007961A1/es active IP Right Grant
- 1997-07-22 IL IL12135997A patent/IL121359A0/xx not_active IP Right Cessation
- 1997-07-22 RU RU97112634/04A patent/RU2180331C2/ru not_active IP Right Cessation
- 1997-07-22 CN CN97115461A patent/CN1064352C/zh not_active Expired - Fee Related
- 1997-07-22 AU AU29418/97A patent/AU726376B2/en not_active Ceased
- 1997-07-22 PL PL97321254A patent/PL189189B1/pl not_active IP Right Cessation
- 1997-07-22 NZ NZ328388A patent/NZ328388A/en unknown
- 1997-07-22 CZ CZ972343A patent/CZ234397A3/cs unknown
- 1997-07-22 SK SK1005-97A patent/SK100597A3/sk unknown
- 1997-07-22 HR HR19629816.4A patent/HRP970404A2/xx not_active Application Discontinuation
- 1997-07-23 ZA ZA9706532A patent/ZA976532B/xx unknown
- 1997-07-23 JP JP19715497A patent/JP4077535B2/ja not_active Expired - Lifetime
- 1997-07-23 NO NO19973399A patent/NO311083B1/no unknown
- 1997-07-23 KR KR1019970034365A patent/KR100541172B1/ko not_active IP Right Cessation
- 1997-07-23 CA CA002211270A patent/CA2211270C/en not_active Expired - Lifetime
- 1997-07-24 ID IDP972573A patent/ID17615A/id unknown
- 1997-07-24 BR BR9704072A patent/BR9704072A/pt not_active Application Discontinuation
- 1997-08-06 TW TW086110367A patent/TW490461B/zh not_active IP Right Cessation
1998
- 1998-06-18 HK HK98105626A patent/HK1006779A1/xx not_active IP Right Cessation
2000
- 2000-06-29 US US09/606,080 patent/US6399620B1/en not_active Expired - Lifetime
2002
- 2002-05-10 US US10/141,986 patent/US7348333B2/en not_active Expired - Fee Related
2007
- 2007-08-21 US US11/892,235 patent/US20080021055A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE19629816A1 (de)	1998-01-29
JPH1143476A (ja)	1999-02-16
JP4077535B2 (ja)	2008-04-16
PL321254A1 (en)	1998-02-02
EP0820991A3 (de)	2000-05-17
EP0820991A2 (de)	1998-01-28
HUP9701264A3 (en)	2001-02-28
US6399620B1 (en)	2002-06-04
NO973399D0 (no)	1997-07-23
EP0820991B1 (de)	2007-08-29
CA2211270C (en)	2009-02-10
KR100541172B1 (ko)	2006-10-24
PL189189B1 (pl)	2005-07-29
RU2180331C2 (ru)	2002-03-10
ATE371650T1 (de)	2007-09-15
HU9701264D0 (en)	1997-09-29
NO311083B1 (no)	2001-10-08
KR980009241A (ko)	1998-04-30
BR9704072A (pt)	1999-01-05
AU726376B2 (en)	2000-11-02
TW490461B (en)	2002-06-11
DE59712879D1 (de)	2007-10-11
SK100597A3 (en)	1998-02-04
CA2211270A1 (en)	1998-01-24
CN1179418A (zh)	1998-04-22
CN1064352C (zh)	2001-04-11
AU2941897A (en)	1998-02-05
HRP970404A2 (en)	1998-04-30
US20030050314A1 (en)	2003-03-13
NZ328388A (en)	1998-07-28
IL121359A0 (en)	1998-01-04
CZ234397A3 (cs)	1998-03-18
AR007961A1 (es)	1999-11-24
ID17615A (id)	1998-01-15
US7348333B2 (en)	2008-03-25
NO973399L (no)	1998-01-26
HUP9701264A1 (hu)	1998-05-28
ZA976532B (en)	1998-04-16
US20080021055A1 (en)	2008-01-24

Publication	Publication Date	Title
IL121359A0 (en)	1998-01-04	Novel cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
PL341216A1 (en)	2001-03-26	Novel derivatives of acyloguanidine as inhibitors of bone resorption and antagonists of vitronectin receptor
HRP970156A2 (en)	1998-04-30	New inhibitors of bone resorption and vitronectin receptor antagonists
IL121358A0 (en)	1998-01-04	Novel imino derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
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