[go: up one dir, main page]

GT200400239A - Procedimiento para la preparacion de una composicion farmaceutica solida administrable oralmente - Google Patents

Procedimiento para la preparacion de una composicion farmaceutica solida administrable oralmente

Info

Publication number
GT200400239A
GT200400239A GT200400239A GT200400239A GT200400239A GT 200400239 A GT200400239 A GT 200400239A GT 200400239 A GT200400239 A GT 200400239A GT 200400239 A GT200400239 A GT 200400239A GT 200400239 A GT200400239 A GT 200400239A
Authority
GT
Guatemala
Prior art keywords
procedure
preparation
pharmaceutical composition
solid pharmaceutical
orally administrable
Prior art date
Application number
GT200400239A
Other languages
English (en)
Inventor
Klaus Benke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34609342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200400239(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200400239A publication Critical patent/GT200400239A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA SOLIDA ADMINISTRABLE ORALMENTE QUE CONTIENE 5CLORON({(5S)2OXO3[4(3OXO4MORFOLINIL)FENIL]1,3OXAZOLIDIN5IL}METIL)2TIOFENCARBOXAMIDA LA CUAL ES DE UTILIDAD EN LA PROFILAXIS Y/O TRATAMIENTO DE DISTINTAS ENFERMEDADES TROBOEMBOLICAS.
GT200400239A 2003-11-27 2004-11-23 Procedimiento para la preparacion de una composicion farmaceutica solida administrable oralmente GT200400239A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10355461A DE10355461A1 (de) 2003-11-27 2003-11-27 Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung

Publications (1)

Publication Number Publication Date
GT200400239A true GT200400239A (es) 2005-07-12

Family

ID=34609342

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200400239A GT200400239A (es) 2003-11-27 2004-11-23 Procedimiento para la preparacion de una composicion farmaceutica solida administrable oralmente

Country Status (35)

Country Link
US (4) US20080026057A1 (es)
EP (1) EP1689370B2 (es)
JP (1) JP4852423B2 (es)
KR (1) KR101151117B1 (es)
CN (1) CN1886120B (es)
AR (2) AR047844A1 (es)
AT (1) ATE385782T1 (es)
AU (1) AU2004305226B2 (es)
BR (1) BRPI0416404B8 (es)
CA (1) CA2547113C (es)
CO (1) CO5690540A2 (es)
CU (1) CU23551B7 (es)
CY (1) CY1107369T1 (es)
DE (2) DE10355461A1 (es)
DK (1) DK1689370T4 (es)
EC (1) ECSP066584A (es)
ES (1) ES2300845T5 (es)
GT (1) GT200400239A (es)
HK (1) HK1099518A1 (es)
HN (1) HN2004000490A (es)
HR (1) HRP20080150T4 (es)
IL (1) IL175860B2 (es)
MA (1) MA28178A1 (es)
MY (1) MY138386A (es)
NO (1) NO340156B1 (es)
NZ (1) NZ547466A (es)
PE (1) PE20050666A1 (es)
PL (1) PL1689370T5 (es)
PT (1) PT1689370E (es)
RU (2) RU2379036C2 (es)
SI (2) SI1689370T2 (es)
TW (1) TWI356702B (es)
UA (1) UA85693C2 (es)
WO (1) WO2005060940A2 (es)
ZA (1) ZA200604166B (es)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
RU2429236C2 (ru) 2005-10-04 2011-09-20 Байер Шеринг Фарма Акциенгезельшафт Новая полиморфная форма и аморфная форма 5-хлор-n-({(5s)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1, 3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047561A1 (de) * 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102006007146A1 (de) 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
TWI351399B (en) * 2006-06-12 2011-11-01 Schering Corp Pharmaceutical formulations and compositions of a
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102006051625A1 (de) * 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
EP2090300A4 (en) * 2006-11-30 2010-02-10 Takeda Pharmaceutical PREPARATION WITH DELAYED RELEASE
EP2120879A2 (en) * 2006-12-22 2009-11-25 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
JP5275815B2 (ja) * 2006-12-26 2013-08-28 塩野義製薬株式会社 リスペリドンを含有する口腔内崩壊錠剤および苦味抑制製剤
HUE035990T2 (en) 2007-03-29 2018-05-28 Daiichi Sankyo Co Ltd Pharmaceutical preparation
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
US8475821B2 (en) * 2008-06-05 2013-07-02 Brain Base Corporation Bone prosthetic material and method of manufacturing the same
EP2303240A1 (en) * 2008-07-08 2011-04-06 Ratiopharm GmbH Pharmaceutical compositions comprising 5-chloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US20110189279A1 (en) * 2008-08-11 2011-08-04 Ratiopharm Gmbh Pharmaceutical compositions with modified release properties comprising 5-chloro-n-(-methyl)-2-thiophencarboxamid
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
US20100287817A1 (en) * 2009-05-14 2010-11-18 Fmc Corporation Method for Ant Control
EP2266541A1 (en) 2009-06-18 2010-12-29 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising rivaroxaban
PT2442799T (pt) 2009-06-18 2016-12-07 Krka Tovarna Zdravil D D Novo Mesto Composição farmacêutica sólida compreendendo rivaroxaban
EP2485715A1 (en) 2009-10-06 2012-08-15 Ratiopharm GmbH Pharmaceutical compositions comprising rivaroxaban
EP2308472A1 (en) 2009-10-06 2011-04-13 ratiopharm GmbH Pharmaceutical compositions comprising rivaroxaban
PL3246021T3 (pl) * 2010-02-25 2020-04-30 Bristol-Myers Squibb Holdings Ireland Unlimited Company Formulacje apiksabanu
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
EP2404920A1 (en) 2010-07-06 2012-01-11 Sandoz AG Crystalline form of Rivaroxaban dihydrate
US10004682B2 (en) * 2010-08-24 2018-06-26 Rutgers, The State University Of New Jersey Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
DE102010063127A1 (de) 2010-12-15 2012-06-21 Bayer Schering Pharma Aktiengesellschaft Flüssige, oral applizierbare pharmazeutische Zusammensetzungen enthaltend 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
US20130064888A1 (en) 2011-08-08 2013-03-14 Roey Solomonovich Pharmaceutical formulations
UY34856A (es) * 2012-07-03 2013-12-31 Bayer Pharma AG Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida
EP2808011A1 (en) * 2013-05-29 2014-12-03 Sandoz Ag Process for the preparation of a pharmaceutical composition comprising Rivaroxaban
CN104337787B (zh) * 2013-08-06 2018-09-07 江苏豪森药业集团有限公司 含有利伐沙班的药物制剂
CN103550165B (zh) * 2013-10-19 2019-07-16 浙江华海药业股份有限公司 一种含有利伐沙班的药物组合物及其制备方法
CN104721156B (zh) * 2013-12-18 2020-05-01 山东新时代药业有限公司 一种含利伐沙班的片剂
WO2015124995A1 (en) 2014-02-19 2015-08-27 Aurobindo Pharma Ltd Solid dosage forms of rivaroxaban
CN104887633B (zh) * 2014-03-04 2019-01-29 山东新时代药业有限公司 一种利伐沙班片剂及其制备方法
CN105078997A (zh) * 2014-05-19 2015-11-25 广东东阳光药业有限公司 一种利伐沙班药用组合物及其制备方法
CN104173313B (zh) * 2014-08-25 2017-05-17 杭州朱养心药业有限公司 利伐沙班片剂药物组合物
KR102271862B1 (ko) 2014-12-31 2021-07-01 한미약품 주식회사 리바록사반 함유 경구용 고형제제
JP2018511158A (ja) * 2015-03-11 2018-04-19 プラスモロジー４，インコーポレイティド 容器処理システム
CN105078915A (zh) * 2015-08-27 2015-11-25 江苏中邦制药有限公司 一种利伐沙班片及其制备方法
CN105287414A (zh) * 2015-10-21 2016-02-03 南京百迪尔生物医药有限公司 一种含有利伐沙班的固体药物组合物及其制备方法
CN105267169B (zh) * 2015-12-07 2018-03-30 石家庄康贺威药业有限公司 一种利伐沙班片剂及其制备方法
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
KR20240014585A (ko) 2016-03-04 2024-02-01 다이호야쿠힌고교 가부시키가이샤 악성 종양 치료용 제제 및 조성물
CA3028346A1 (en) * 2016-07-05 2018-01-11 Alphamed Formulations Pvt. Ltd Solid composition containing oral anticoagulant
CN106109434B (zh) * 2016-08-26 2019-04-05 乐普药业股份有限公司 一种利伐沙班片剂及其制备方法
JP6574041B2 (ja) * 2017-12-15 2019-09-11 エルメッド株式会社 リバーロキサバン含有医薬組成物
EP3505160A1 (en) 2017-12-31 2019-07-03 Abdi Ibrahim Ilac Sanayi ve Ticaret A.S. Preparation of a solid pharmaceutical composition comprising rivaroxaban and production thereof
US10828310B2 (en) 2018-02-02 2020-11-10 Bayer Pharma Aktiengesellschaft Reducing the risk of cardiovascular events
DK3769765T3 (da) 2018-03-19 2024-05-13 Taiho Pharmaceutical Co Ltd Farmaceutisk sammensætning indeholdende natriumalkylsulfat
CN108864069B (zh) * 2018-05-03 2021-04-20 华东理工大学 一种利伐沙班微粒及其制备方法与应用
GR1009619B (el) * 2018-05-09 2019-10-23 Φαρμαζακ Α.Φ.Ε.Β.Ε. Φαρμακευτικη συνθεση που περιεχει ριβαροξαβανη και μεθοδος για την παρασκευη αυτης
JP2020029455A (ja) * 2018-08-20 2020-02-27 大原薬品工業株式会社 微粉砕されたリバーロキサバンを含有してなる固形製剤
JP2021535120A (ja) * 2018-08-30 2021-12-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の、無駄のない、環境に配慮した造粒方法
WO2020101587A1 (en) 2018-11-16 2020-05-22 Santa Farma İlaç Sanayi̇ A.Ş. Oral formulations comprising rivaroxaban
JP7305527B2 (ja) * 2018-11-30 2023-07-10 大原薬品工業株式会社 リバーロキサバンと嬌味剤を含有する固形製剤
JP7641098B2 (ja) 2019-08-30 2025-03-06 日本ジェネリック株式会社 リバーロキサバン含有錠剤
CN112675136B (zh) * 2019-10-18 2023-05-16 苏州特瑞药业股份有限公司 降低利伐沙班出血风险的组合物及其制备方法
KR102290670B1 (ko) 2019-12-30 2021-08-18 단국대학교 천안캠퍼스 산학협력단 자가나노유화 약물전달시스템을 이용한 리바록사반의 경구용 고형제 조성물 및 이의 제조방법
US20210267908A1 (en) * 2020-03-02 2021-09-02 Mankind Pharma Ltd. Pharmaceutical compositions of rivaroxaban
EP4208462A4 (en) * 2020-09-05 2024-09-11 Inventia Healthcare Limited Rivaroxaban compositions
JP7511596B2 (ja) 2021-03-10 2024-07-05 日本ジェネリック株式会社 リバーロキサバン含有錠剤
GR1010231B (el) 2021-03-24 2022-05-10 Φαρματεν Α.Β.Ε.Ε., Φαρμακευτικο σκευασμα που περιλαμβανει ριβαροξαμπανη και μεθοδος παρασκευης αυτου
CN113425729B (zh) * 2021-06-24 2022-11-15 上海奥全生物医药科技有限公司 一种含有利伐沙班的药物组合物及其应用
WO2023067620A1 (en) * 2021-10-18 2023-04-27 Unison Pharmaceuticals Pvt. Ltd. Orally disintegrating pharmaceutical compositions of rivaroxaban
WO2023194885A1 (en) 2022-04-08 2023-10-12 Intas Pharmaceuticals Ltd. An orodispersible tablet of rivaroxaban
CN116869952A (zh) * 2022-06-16 2023-10-13 北京四环制药有限公司 一种高稳定性的利伐沙班药物组合物及其制备方法
CN115590856A (zh) * 2022-10-31 2023-01-13 南京海纳医药科技股份有限公司（Cn） 一种含有利伐沙班的药物组合物及其制备方法

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2811555A (en) 1955-05-02 1957-10-29 Eastman Kodak Co Reduction of 2-nitroso-5-diethylaminotoluene
US3279880A (en) 1965-07-12 1966-10-18 Eastman Kodak Co Polyester textile material dyed with 1-hydroxy-4-n-p-(2'-pyrrolidonyl-1-) phenyl-amino anthraquinones
LU80081A1 (fr) 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4500519A (en) 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
JPS5611061A (en) 1979-07-07 1981-02-04 Seikichi Nakajima Water circulation electrolytic device
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
HU190072B (en) 1983-03-11 1986-08-28 Biogal Gyogyszergyar,Hu Process for production of medical preparatives with sinergetic influence
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
NZ206600A (en) 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
ES8506659A1 (es) 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
DE3433239A1 (de) * 1984-09-11 1986-03-20 Bayer Ag, 5090 Leverkusen Feste arzneizubereitung enthaltend nitrendipin und verfahren zu ihrer herstellung
ATE95176T1 (de) 1987-10-21 1993-10-15 Du Pont Merck Pharma Aminomethyl-oxo-oxazolidinyl-ethenylbenzenderivate, nuetzlich als antibakterielles mittel.
US4977173A (en) 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
DE3822650A1 (de) 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
TW212139B (es) 1991-04-15 1993-09-01 Yamanouchi Pharma Co Ltd
KR100257418B1 (ko) 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
DK0623615T3 (da) 1993-05-01 1999-12-13 Merck Patent Gmbh Adhæsionsreceptor-antagonister
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4332384A1 (de) 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
NZ302844A (en) 1995-02-03 1999-06-29 Upjohn Co Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones
HRP960159A2 (en) 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
HUP9601808A3 (en) 1995-07-03 2000-06-28 Sankyo Co Treatment of arteriosclerosis and xanthoma
DE19524765A1 (de) 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
MX9801578A (es) 1995-09-01 1998-08-30 Upjohn Co Feniloxazolidinonas que tienen un enlace c-c para anillos heterociclicos de 4-8 miembros.
WO1997010223A1 (en) 1995-09-15 1997-03-20 Pharmacia & Upjohn Company Aminoaryl oxazolidinone n-oxides
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
RU2194038C2 (ru) * 1996-05-01 2002-12-10 Орто-Макнейл Фармасьютикал, Инк. Карбоксамидные производные пирролидина или пиперидина, фармацевтическая композиция на их основе и способ ингибирования агрегации тромбоцитов
EP0914100A1 (en) 1996-06-28 1999-05-12 Schering Corporation Oral composition comprising a triazole antifungal compound
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
EP0930076B1 (en) 1996-07-15 2004-12-01 Sankyo Company Limited Pharmaceutical compositions comprising CS-866 and insulin resistance improving agents and their use for the treatment of arteriosclerosis and xanthoma
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
FR2759585B1 (fr) * 1997-02-17 1999-06-11 Sanofi Sa Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique
US5935724A (en) 1997-04-04 1999-08-10 Wilson Greatbatch Ltd. Electrochemical cell having multiplate electrodes with differing discharge rate regions
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
DE69829846T2 (de) 1997-05-30 2006-02-23 Pharmacia & Upjohn Co. Llc, Kalamazoo Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
CA2294293A1 (en) 1997-07-11 1999-01-21 Pharmacia & Upjohn Company Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
DE19730847A1 (de) 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
DE19747261A1 (de) 1997-10-25 1999-04-29 Bayer Ag Osmotisches Arzneimittelfreisetzungssystem
PT1030852E (pt) 1997-11-12 2004-02-27 Upjohn Co Derivados de oxazolidinona e composicoes farmaceuticas
US6083967A (en) 1997-12-05 2000-07-04 Pharmacia & Upjohn Company S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones
DE19755268A1 (de) 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
JP2002501059A (ja) 1998-01-23 2002-01-15 ファルマシア・アンド・アップジョン・カンパニー オキサゾリジノンの組合せライブラリー、組成物および調製方法
TR200002182T2 (tr) 1998-01-27 2000-12-21 Aventis Pharmaceuticals Products Inc. İkame edilmiş aksozaherosayklil faktör xa inhibitörleri
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
CZ291945B6 (cs) 1998-05-18 2003-06-18 Pharmacia & Upjohn Company Použití oxazolidinonových antibakteriálních látek a derivátů argininu a farmaceutická kompozice
DE19842753A1 (de) 1998-09-18 2000-03-23 Bayer Ag Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
PE20010851A1 (es) 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
CA2389482A1 (en) 1999-12-21 2001-06-28 Jackson B. Hester, Jr. Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
RU2222544C1 (ru) 1999-12-28 2004-01-27 Адзиномото Ко., Инк. Кристалл производного аспартама
US6514529B2 (en) * 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
PE20020300A1 (es) 2000-08-22 2002-05-10 Pharmacia Corp Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco
KR100415318B1 (ko) 2000-09-23 2004-01-16 탁승호 레이저를 이용한 수평 및 수직선 지시계
WO2002038126A2 (en) 2000-11-08 2002-05-16 Aeromatic-Fielder Ag A process for production of particles for pharmaceutical compositions having increased bioavailability
KR20030076634A (ko) 2001-01-30 2003-09-26 데이진 가부시키가이샤 의약 조성물
DE10105989A1 (de) 2001-02-09 2002-08-14 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10110438A1 (de) 2001-03-05 2002-09-19 Bayer Ag Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110747A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
DE10110754A1 (de) 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115945A1 (de) 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10115922A1 (de) 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10134481A1 (de) 2001-07-16 2003-01-30 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
DE10152460A1 (de) 2001-10-24 2003-05-08 Bayer Ag Stents
DE10238113A1 (de) 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
US20030161882A1 (en) 2002-02-01 2003-08-28 Waterman Kenneth C. Osmotic delivery system
DE10300111A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
DE102004062475A1 (de) 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
RU2429236C2 (ru) 2005-10-04 2011-09-20 Байер Шеринг Фарма Акциенгезельшафт Новая полиморфная форма и аморфная форма 5-хлор-n-({(5s)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1, 3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005047558A1 (de) 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005048824A1 (de) 2005-10-10 2007-04-12 Bayer Healthcare Ag Behandlung und Prophylaxe von Mikroangiopathien
DE102006034916A1 (de) 2006-07-28 2008-01-31 Bayer Healthcare Ag Beschichtung künstlicher Oberflächen von medizinischen Hilfsmitteln und Geräten sowie Reinigung und/oder Vorbehandlung von Kathetern und anderen medizinischen Hilfsmitteln und Geräten
DE102006051625A1 (de) 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone

Also Published As

Publication number Publication date
NZ547466A (en) 2009-12-24
UA85693C2 (ru) 2009-02-25
ZA200604166B (en) 2007-10-31
ATE385782T1 (de) 2008-03-15
CY1107369T1 (el) 2012-12-19
CN1886120A (zh) 2006-12-27
AR047844A1 (es) 2006-03-01
BRPI0416404B1 (pt) 2018-08-07
RU2009127302A (ru) 2011-01-27
CA2547113C (en) 2012-01-24
HRP20080150T4 (hr) 2016-12-16
HRP20080150T3 (en) 2008-04-30
US9415053B2 (en) 2016-08-16
DK1689370T3 (da) 2008-06-09
DK1689370T4 (da) 2017-01-02
US20140248349A1 (en) 2014-09-04
DE10355461A1 (de) 2005-06-23
CN1886120B (zh) 2010-08-11
JP2007512274A (ja) 2007-05-17
NO20062942L (no) 2006-06-23
RU2379036C2 (ru) 2010-01-20
IL175860B2 (en) 2024-01-01
ES2300845T5 (es) 2017-05-16
KR20060117330A (ko) 2006-11-16
KR101151117B1 (ko) 2012-06-01
MA28178A1 (fr) 2006-09-01
RU2493850C2 (ru) 2013-09-27
CA2547113A1 (en) 2005-07-07
NO340156B1 (no) 2017-03-13
BRPI0416404A (pt) 2007-01-09
TW200529859A (en) 2005-09-16
AR104840A2 (es) 2017-08-16
AU2004305226A1 (en) 2005-07-07
CU23551B7 (es) 2010-07-20
SI1689370T2 (sl) 2017-01-31
RU2006122599A (ru) 2008-01-10
JP4852423B2 (ja) 2012-01-11
HN2004000490A (es) 2008-06-24
PL1689370T3 (pl) 2008-07-31
BRPI0416404B8 (pt) 2021-05-25
SI1689370T1 (sl) 2008-06-30
US20150037415A1 (en) 2015-02-05
IL175860A (en) 2015-11-30
WO2005060940A3 (de) 2006-03-30
US20080026057A1 (en) 2008-01-31
MY138386A (en) 2009-05-29
US9402851B2 (en) 2016-08-02
DE502004006218D1 (de) 2008-03-27
ECSP066584A (es) 2006-10-17
US20170007612A1 (en) 2017-01-12
IL175860A0 (en) 2006-10-05
ES2300845T3 (es) 2008-06-16
WO2005060940A2 (de) 2005-07-07
PL1689370T5 (pl) 2017-09-29
EP1689370A2 (de) 2006-08-16
PT1689370E (pt) 2008-05-09
HK1099518A1 (en) 2007-08-17
AU2004305226B2 (en) 2010-06-17
PE20050666A1 (es) 2005-12-02
EP1689370B1 (de) 2008-02-13
TWI356702B (en) 2012-01-21
EP1689370B2 (de) 2016-09-14
CO5690540A2 (es) 2006-10-31

Similar Documents

Publication Publication Date Title
GT200400239A (es) Procedimiento para la preparacion de una composicion farmaceutica solida administrable oralmente
CY1111470T1 (el) Νεες φαρμακευτικες συνθεσεις που περιεχουν φλιβανσερινη πολυμορφη α
CY1111433T1 (el) Φαρμακευτικο τυποποιημενο παρασκευασμα δεσιταβινης
ECSP045429A (es) Combinacion de compuestos organicos
EA200501268A1 (ru) Ингибирующие вич 1,2,4-триазины
WO2007075598A3 (en) N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
EA200401114A2 (ru) Замещённые гидроксиэтиламины
NO20082768L (no) Levodopa prodroge mesylat, sammensetninger og anvendelser derav
BRPI0411743A (pt) método e composições para tratar doenças relacionadas a amilóides
CY1108992T1 (el) Η χρηση του υαλουρονικου οξεος για την παρασκευη συνθεσεων για τη θεραπευτικη αντιμετωπιση υποτροπιαζουσων αφθων της στοματικης κοιλοτητας
UY29445A1 (es) Composiciones para la transmisión transmucosa oral de la metformina
EA200501821A1 (ru) Фармацевтическая комбинация, содержащая модафинил и другой лекарственный препарат
DK1670903T3 (da) Behandling af neurodegenerative sygdomme
BRPI0410044A (pt) forma de dosagem contendo pantoprazol como ingrediente ativo
EA200700637A1 (ru) Соли донепезила, подходящие для получения фармацевтических композиций
UY29817A1 (es) Nuevos compuestos de azetidina, composiciones farmacéuticas que los contienen, procesos de preparación y uso terapéutico de los mismos.
SE0400708D0 (sv) New compounds and use thereof
PA8547801A1 (es) Microcápsula para la protección frente al mal aliento
ATE496899T1 (de) Tetrahydro- und dihydrochinazolinone
ECSP066292A (es) Sistemas semi-sólidos que contienen derivados de azetidina
ATE493976T1 (de) Bakuchiol enthaltende pharmazeutische zusammensetzung zur behandlung von weiblicher osteoporose
UA40495A (uk) Склад для лікування захворювань ясен
ITMI20031273A1 (it) Composizioni a base di cenere di vegetali per la terapia di affezioni cutanee.
HN2002000049A (es) Nuevos compuestos antiinflamatorios de triazolopiridinas