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GT200400136A - 3.5-DISPOSED INDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT CELLULAR APPROVALIFERATION. - Google Patents

3.5-DISPOSED INDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT CELLULAR APPROVALIFERATION.

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Publication number
GT200400136A
GT200400136A GT200400136A GT200400136A GT200400136A GT 200400136 A GT200400136 A GT 200400136A GT 200400136 A GT200400136 A GT 200400136A GT 200400136 A GT200400136 A GT 200400136A GT 200400136 A GT200400136 A GT 200400136A
Authority
GT
Guatemala
Prior art keywords
compounds
intervene
disposed
methods
pharmaceutical compositions
Prior art date
Application number
GT200400136A
Other languages
Spanish (es)
Inventor
Susan Elizabeth Kephart
Indrawan James Mcalpine
Seigfried Heins Reich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200400136A publication Critical patent/GT200400136A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE INDAZOL 3,5DISUSTITUIDOS QUE MODULAN Y/O INHIBEN LA PROLIFERACION CELULAR TAL COMO LA ACTIVIDAD DE LAS PROTEINAS QUINASAS. ESTOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN SON CAPACES DE INTERVENIR EN ENFERMEDADES DEPENDIENTES DE LA CDK PARA MODULAR Y/O INHIBIR LA PROLIFERACION CELULARA NO DESEADA. LA INVENCION TAMBIEN SE DIRIGE AL USO TERAPEUTICO O PROFILACTICO DE COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES COMPUESTOS Y A METODOS PARA TRATAR EL CANCER ASI COMO OTRAS CONDICIONES PATOLOGICAS ASOCIADAS CON ANGIOGENESIS Y/O PROLIFERACION CELULAR, NO DESEADA, TALES COMO: RETINOPATIA DIABETICA, GLAUCOMA NEOVASCULAR, ARTRITIS REUMATOIDE Y SORIASIS, POR ADMINISTRACION DE CANTIDADES EFICACES DE TALES COMPUESTOS.INDAZOL COMPOUNDS 3.5 DISPOSED THAT MODULATE AND / OR INHIBIT CELLULAR PROLIFERATION SUCH AS THE ACTIVITY OF KINASE PROTEINS. THESE PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM ARE ABLE TO INTERVENE IN DEPENDENT DISEASES OF THE CDK TO MODULATE AND / OR INHIBIT THE UNWANTED CELLULAR PROLIFERATION. THE INVENTION IS ALSO ADDRESSED TO THE THERAPEUTIC OR PROFILACTIC USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS TO TREAT CANCER AS WELL AS OTHER PATHOLOGICAL CONDITIONS ASSOCIATED WITH ANGIOGENESIS AND / OR PROLIFTIATIMED ROLLAR, DISTRIBUTED CELEBRATION, ASSOCIATED BY NUMBER REUMATOID AND SORIASIS, BY ADMINISTRATION OF EFFECTIVE AMOUNTS OF SUCH COMPOUNDS.

GT200400136A 2003-07-30 2004-07-19 3.5-DISPOSED INDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT CELLULAR APPROVALIFERATION. GT200400136A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49147403P 2003-07-30 2003-07-30

Publications (1)

Publication Number Publication Date
GT200400136A true GT200400136A (en) 2005-05-02

Family

ID=36947517

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200400136A GT200400136A (en) 2003-07-30 2004-07-19 3.5-DISPOSED INDAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS TO INTERVENE IN OR INHIBIT CELLULAR APPROVALIFERATION.

Country Status (3)

Country Link
CN (1) CN1829713A (en)
GT (1) GT200400136A (en)
ZA (1) ZA200600821B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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CA2737694C (en) * 2008-09-26 2013-07-02 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN102595900B (en) 2009-08-10 2015-07-15 萨穆梅德有限公司 Indazole Inhibitors of the Wnt Signaling Pathway and Their Therapeutic Uses
EP2464231A4 (en) * 2009-08-10 2013-02-06 Samumed Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof
EP2515655B1 (en) 2009-12-21 2015-08-05 Samumed, LLC 1h-pyrazolo[3,4-beta]pyridines and therapeutic uses thereof
CN102675286B (en) * 2011-03-07 2015-08-19 中国科学院上海药物研究所 Indazole compounds, preparation method, application and pharmaceutical composition thereof
AU2012308570B2 (en) 2011-09-14 2016-11-10 Samumed, Llc Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
SG10201710585UA (en) 2012-05-04 2018-02-27 Samumed Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
CA2897400A1 (en) 2013-01-08 2014-07-17 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
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WO2017024010A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023987A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
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US10188634B2 (en) 2015-08-03 2019-01-29 Samumed, Llc 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
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US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023986A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024021A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
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RU2770613C2 (en) 2016-10-21 2022-04-19 СЭМЬЮМЕД, ЭлЭлСи Methods for using indazole-3-carboxamides and their use as inhibitors of wnt/b-catenin signal path
WO2018085865A1 (en) 2016-11-07 2018-05-11 Samumed, Llc Single-dose, ready-to-use injectable formulations

Also Published As

Publication number Publication date
ZA200600821B (en) 2007-04-25
CN1829713A (en) 2006-09-06

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