GT200200055A - Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos - Google Patents
Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicosInfo
- Publication number
- GT200200055A GT200200055A GT200200055A GT200200055A GT200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A
- Authority
- GT
- Guatemala
- Prior art keywords
- pcp
- type
- heterociclilpropanohidroxamicos
- acids
- formation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE INHIBEN LA PROCOLAGENO C PROTEINASA (PCP) DEL TIPO DE ACIDOS 3HETEROCICLILPROPANOHIDROXAMICOS DE FORMULA GENERAL (I) EN DONDE R, X, X1,Y1, R,W, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS REDUCEN LA FORMACION Y DEPOSICION DE COLAGENO POR LA INHIBICION DE LA PCP REDUCIENDO CON ELLO LA FORMACION DE TEJIDO DE ESCARAS POR LO QUE SON DE INTERES COMO ANTIESCARIFICANTE DE HERIDAS Y OTROS TRASTORNOS MEDIADOS POR PCP.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108097.7A GB0108097D0 (en) | 2001-03-30 | 2001-03-30 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200200055A true GT200200055A (es) | 2002-11-21 |
Family
ID=9911979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200200055A GT200200055A (es) | 2001-03-30 | 2002-03-21 | Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1373231B1 (es) |
| JP (1) | JP2004524364A (es) |
| AP (1) | AP2002002464A0 (es) |
| AT (1) | ATE297382T1 (es) |
| BR (1) | BR0208500A (es) |
| CA (1) | CA2442483C (es) |
| DE (1) | DE60204552T2 (es) |
| ES (1) | ES2240703T3 (es) |
| GB (1) | GB0108097D0 (es) |
| GT (1) | GT200200055A (es) |
| MX (1) | MXPA03008849A (es) |
| PA (1) | PA8542301A1 (es) |
| PE (1) | PE20021104A1 (es) |
| TN (1) | TNSN02035A1 (es) |
| UY (1) | UY27231A1 (es) |
| WO (1) | WO2002079175A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009097893A1 (en) * | 2008-02-04 | 2009-08-13 | Proyecto De Biomedicina Cima, S.L. | Methods for the treatment of cardiac disease associated to myocardial fibrosis using an inhibitor of pcp |
| SG11201605539SA (en) | 2014-01-10 | 2016-08-30 | Glaxosmithkline Ip No 2 Ltd | Hydroxy formamide derivatives and their use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9916504A (pt) * | 1998-12-22 | 2001-09-11 | Hoffmann La Roche | Hidroxamatos de sulfonamida |
| CA2366954A1 (en) * | 1999-03-03 | 2000-09-08 | The Procter & Gamble Company | Dihetero-substituted metalloprotease inhibitors |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
-
2001
- 2001-03-30 GB GBGB0108097.7A patent/GB0108097D0/en not_active Ceased
-
2002
- 2002-03-18 ES ES02707045T patent/ES2240703T3/es not_active Expired - Lifetime
- 2002-03-18 CA CA002442483A patent/CA2442483C/en not_active Expired - Fee Related
- 2002-03-18 MX MXPA03008849A patent/MXPA03008849A/es active IP Right Grant
- 2002-03-18 BR BR0208500-3A patent/BR0208500A/pt not_active IP Right Cessation
- 2002-03-18 DE DE60204552T patent/DE60204552T2/de not_active Expired - Fee Related
- 2002-03-18 WO PCT/IB2002/000817 patent/WO2002079175A1/en active IP Right Grant
- 2002-03-18 JP JP2002577802A patent/JP2004524364A/ja not_active Ceased
- 2002-03-18 AT AT02707045T patent/ATE297382T1/de not_active IP Right Cessation
- 2002-03-18 EP EP02707045A patent/EP1373231B1/en not_active Expired - Lifetime
- 2002-03-21 GT GT200200055A patent/GT200200055A/es unknown
- 2002-03-27 UY UY27231A patent/UY27231A1/es not_active Application Discontinuation
- 2002-03-27 PA PA20028542301A patent/PA8542301A1/es unknown
- 2002-03-27 PE PE2002000250A patent/PE20021104A1/es not_active Application Discontinuation
- 2002-03-28 AP APAP/P/2002/002464A patent/AP2002002464A0/en unknown
- 2002-03-29 TN TNTNSN02035A patent/TNSN02035A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AP2002002464A0 (en) | 2002-06-30 |
| TNSN02035A1 (fr) | 2005-12-23 |
| PA8542301A1 (es) | 2002-10-28 |
| ATE297382T1 (de) | 2005-06-15 |
| EP1373231B1 (en) | 2005-06-08 |
| ES2240703T3 (es) | 2005-10-16 |
| DE60204552T2 (de) | 2006-05-11 |
| WO2002079175A1 (en) | 2002-10-10 |
| MXPA03008849A (es) | 2003-12-11 |
| JP2004524364A (ja) | 2004-08-12 |
| EP1373231A1 (en) | 2004-01-02 |
| CA2442483C (en) | 2007-11-13 |
| BR0208500A (pt) | 2004-04-20 |
| DE60204552D1 (en) | 2005-07-14 |
| UY27231A1 (es) | 2002-11-29 |
| GB0108097D0 (en) | 2001-05-23 |
| CA2442483A1 (en) | 2002-10-10 |
| PE20021104A1 (es) | 2002-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GT200200027A (es) | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz | |
| GT200200014A (es) | Inhibidores de piridina de metaloproteinasas de la matriz | |
| MX2021008176A (es) | Inhibidores imidazo[1,2-b]piridazina de il-17a. | |
| HN2009000792A (es) | Inhibidores de la proteasa ns3 del hcv | |
| MX379543B (es) | Purinonas como inhibidores de proteasa específica de ubiquitina 1. | |
| GT200200053A (es) | Derivados espirociclicos nuevos y su uso como inhibidores de fosfodiesterasa-7 | |
| GT200200248A (es) | Inhibidores del factor xa y de otras proteasas de serina implicadas en la cascada de la coagulacion | |
| GT200500208A (es) | Indazoles ùtiles para tratar enfermedades cardiovasculares | |
| BRPI0512683A (pt) | compostos anti-virais | |
| CO6430431A2 (es) | Inhibidores del virus de la hepatitis c | |
| HN2011001256A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratmiento o prevencion de diabetes | |
| BRPI0508085A (pt) | compostos de enxofre como inibidores da ns3 serina protease do vìrus da hepatite c | |
| CR10567A (es) | Peptidomimeticos de smac utiles como inhibidores de proteinas de apoptosis (iap) | |
| DOP2007000051A (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevención de diabetes | |
| BRPI0915692B8 (pt) | compostos derivados de 1,2,5-oxadiazóis, sua forma sólida, sua composição, bem como seus usos | |
| SV2005001973A (es) | Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500) | |
| BRPI0416902A (pt) | inibidores de ns3/ns4a serina protease do vìrus da hepatite c | |
| ECSP088358A (es) | Tratamiento y profilaxis de microangiopatías | |
| NI200600217A (es) | Derivados de imidazol utilizados como inhibidores de tafia | |
| CL2003002665A1 (es) | COMPUESTOS DERIVADOS DE ACIDOS CARBOXILICOS, SUS SALES; PROCEDIMIENTO DE PREPARACION; COMPOSICION FARMACEUTICA, Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES DONDE ES NECESARIO UN INHIBIDORE DEL FACTOR Xa Y /O UN INHIBIDOR DE SERINA PROTEASA. | |
| PA8601001A1 (es) | Fenacilo 2-hidroxi-3-diaminoalcanos | |
| ECSP066997A (es) | Derivados de pirimidina para tratar el crecimiento celular anómalo | |
| CR8930A (es) | Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) | |
| GT200200062A (es) | Inhibidores de pcp basados en acidos 3-heterociclilpropanohidroxamicos | |
| GT200100251A (es) | Procedimiento para la preparacion de imidazotriazinonas substituidas con sulfonamida |