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GR910100087A - Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε. - Google Patents

Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε.

Info

Publication number
GR910100087A
GR910100087A GR910100087A GR910100087A GR910100087A GR 910100087 A GR910100087 A GR 910100087A GR 910100087 A GR910100087 A GR 910100087A GR 910100087 A GR910100087 A GR 910100087A GR 910100087 A GR910100087 A GR 910100087A
Authority
GR
Greece
Prior art keywords
apolipoprotein
polypeptide
person
polypeptide analogs
lrklrkrllrdaddl
Prior art date
Application number
GR910100087A
Other languages
English (en)
Inventor
K Linda Curtiss
A Cheryl Dyer
Richard Smith
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of GR910100087A publication Critical patent/GR910100087A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεσις αφορά εις μέ?οδον ?εραπείας της υπερ- χοληστεριναιμίας εις ασ?ενή, ήτις μέ?οδος περιλαμβάνει την χορήγησιν εις τον ασ?ενή μιας μειούσης την εις το πλάσμα συγκέντρωσιν της LDL ποσότητας πολυμερούς πολυπεπτιδίου δυναμένου να δεσμεύσει τον υποδοχέα της LDL. Η επαναλαμβανομένη μονάς του πολυπεπτιδίου έχει αλληλουχίαν ριζών αμινοξέων αντιστοιχούσαν εις την αντιπροσωπευομένην υπό του τύπου: LRKLRKRLLRDADDL ω
GR910100087A 1990-02-26 1991-02-21 Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε. GR910100087A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/485,158 US5182364A (en) 1990-02-26 1990-02-26 Polypeptide analogs of apolipoprotein E

Publications (1)

Publication Number Publication Date
GR910100087A true GR910100087A (el) 1992-06-30

Family

ID=23927117

Family Applications (1)

Application Number Title Priority Date Filing Date
GR910100087A GR910100087A (el) 1990-02-26 1991-02-21 Πολυπεπτιδικα αναλογα της απολιποπρωτεινης ε.

Country Status (2)

Country Link
US (1) US5182364A (el)
GR (1) GR910100087A (el)

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DE69321118T2 (de) * 1992-06-12 1999-06-02 Naamloze Vennootschap Innogenetics S.A., Gent Peptide und Proteine, Verfahren zur Ihren Herstellung und die Verwendung als Cholesterol-Annehmer
DE69333461T2 (de) * 1992-10-13 2005-03-24 Duke University VERFAHREN ZUM nachweis der Alzheimer Krankheit
US6277874B1 (en) * 1996-07-09 2001-08-21 University Of Cincinnati And Apologic, Incorporated Methods for the treatment of apolipoprotein E related diseases
US7205280B2 (en) 1998-03-11 2007-04-17 Cognosci, Inc. Methods of suppressing microglial activation
US20030077641A1 (en) * 1998-03-11 2003-04-24 Laskowitz Daniel T. Methods of suppressing microglial activation and systemic inflammatory responses
IL139217A0 (en) * 2000-03-13 2001-11-25 Applied Research Systems Monoclonal antibodies to the human ldl receptor, their production and use
AU1384302A (en) * 2000-11-10 2002-05-21 Proteopharma Aps Apolipoprotein analogues
AU2003248786A1 (en) * 2002-07-03 2004-01-23 Esperion Therapeutics, Inc. Compositions comprising panthetine for the treatment of dyslipidemia
US8034762B2 (en) * 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
CN104558200B (zh) * 2004-09-02 2021-11-16 康石医药科技（上海）有限公司 改进的apo e类似物及其使用方法
US20080199398A1 (en) * 2006-06-16 2008-08-21 Brewer H Bryan Novel Peptides That Promote Lipid Efflux
US20080206142A1 (en) * 2006-06-16 2008-08-28 Lipid Sciences, Inc. Novel Peptides That Promote Lipid Efflux
US20080227686A1 (en) * 2006-06-16 2008-09-18 Lipid Sciences, Inc. Novel Peptides that Promote Lipid Efflux
WO2008039843A2 (en) * 2006-09-26 2008-04-03 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
JP5832898B2 (ja) 2008-11-10 2015-12-16 テクミラ ファーマシューティカルズ コーポレイションＴｅｋｍｉｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 治療薬を送達するための新規な脂質及び組成物
EP3243504A1 (en) 2009-01-29 2017-11-15 Arbutus Biopharma Corporation Improved lipid formulation
WO2010105209A1 (en) 2009-03-12 2010-09-16 Alnylam Pharmaceuticals, Inc. LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
CN105903022A (zh) 2009-05-05 2016-08-31 阿尔尼拉姆医药品有限公司 脂质组合物
JP5819291B2 (ja) 2009-06-10 2015-11-24 テクミラ ファーマシューティカルズ コーポレイションＴｅｋｍｉｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 改善された脂質製剤
WO2011020023A2 (en) 2009-08-14 2011-02-17 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
AU2010328336B2 (en) 2009-12-07 2017-03-02 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
WO2011075656A1 (en) 2009-12-18 2011-06-23 The University Of British Columbia Methods and compositions for delivery of nucleic acids
US20130156845A1 (en) 2010-04-29 2013-06-20 Alnylam Pharmaceuticals, Inc. Lipid formulated single stranded rna
US10077232B2 (en) 2010-05-12 2018-09-18 Arbutus Biopharma Corporation Cyclic cationic lipids and methods of use
JP2013527856A (ja) 2010-05-12 2013-07-04 プロチバ バイオセラピューティクス インコーポレイティッド 陽イオン性脂質およびその使用方法
JP5893611B2 (ja) 2010-06-03 2016-03-23 アルニラム・ファーマシューティカルズ・インコーポレーテッド 活性剤の送達のための生分解性脂質
WO2012016184A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
WO2012016188A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
CN110123830A (zh) 2010-11-09 2019-08-16 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
CA2824526C (en) 2011-01-11 2020-07-07 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
WO2013049328A1 (en) 2011-09-27 2013-04-04 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
WO2014011908A1 (en) 2012-07-11 2014-01-16 Esperion Therapeutics, Inc. Apolipoprotein mixtures

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
ZA884504B (en) * 1987-06-29 1989-03-29 Merrell Dow Pharma Immunosuppressant peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
No further relevant documents have been disclosed. *

Also Published As

Publication number Publication date
US5182364A (en) 1993-01-26

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