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GR890100541A - METHODS FOR THE PRODUCTION OF GERADOTROPINIS & TSH EXPERIENCES AND THE HYPER-EMPLOYEES WHO ARE PRODUCED WITH THIS WAY. - Google Patents

METHODS FOR THE PRODUCTION OF GERADOTROPINIS & TSH EXPERIENCES AND THE HYPER-EMPLOYEES WHO ARE PRODUCED WITH THIS WAY.

Info

Publication number
GR890100541A
GR890100541A GR890100541A GR890100541A GR890100541A GR 890100541 A GR890100541 A GR 890100541A GR 890100541 A GR890100541 A GR 890100541A GR 890100541 A GR890100541 A GR 890100541A GR 890100541 A GR890100541 A GR 890100541A
Authority
GR
Greece
Prior art keywords
tsh
production
horse
geradotropinis
employees
Prior art date
Application number
GR890100541A
Other languages
Greek (el)
Inventor
C Scott Chappel
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of GR890100541A publication Critical patent/GR890100541A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Οι μέ?οδοι που προβλέπονται για την παραγωγή ορμονικών υπερσυναγωνιστών, οι οποίες ορμόνες είναι εκείνες που έχουν την κοινή άλφα υπομονάδα των γοναδοτροπινών, που γενικώς περιέχουν τον μετασχηματισμό των κυττάρων ξενιστών με ανασυνδυαζόμενο DNA που περιλαμβάνει μία πρώτη αλληλουχία DNA που κωδικοποιεί μια άλφα υπομονάδα ενός είδους αλόγου και μία δεύτερη αλληλουχία DNA που κωδικοποιεί μία βήτα υπομονάδα ενός είδους διαφορετικού από το άλογο. Η πρωτιμώμενη ορμόνη περιλαμβάνει μία άλφα υπομονάδα αλόγου και μία βήτα υπομονάδα της LH ή της FSH ή της CG ή της TSH του βοδιού ή του χοίρου ή του αν?ρώπου και παρουσιάζει μία κατά πολύ αυξημένη δραστικότητα. ωThe methods provided for the production of hormone superconcipients, which are hormones having the common alpha subunit of gonadotropins, generally containing the transformation of host cells into recombinant DNA comprising a first DNA sequence encoding a species encoding horse and a second DNA sequence encoding a beta subunit of a species other than horse. The preferred hormone comprises an alpha horse subunit and a beta subunit of LH or FSH or CG or TSH of bovine or porcine or human and exhibits a greatly increased activity. ω

GR890100541A 1988-09-01 1989-08-30 METHODS FOR THE PRODUCTION OF GERADOTROPINIS & TSH EXPERIENCES AND THE HYPER-EMPLOYEES WHO ARE PRODUCED WITH THIS WAY. GR890100541A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23972188A 1988-09-01 1988-09-01

Publications (1)

Publication Number Publication Date
GR890100541A true GR890100541A (en) 1990-10-31

Family

ID=22903429

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100541A GR890100541A (en) 1988-09-01 1989-08-30 METHODS FOR THE PRODUCTION OF GERADOTROPINIS & TSH EXPERIENCES AND THE HYPER-EMPLOYEES WHO ARE PRODUCED WITH THIS WAY.

Country Status (10)

Country Link
EP (1) EP0386203A1 (en)
JP (1) JPH03502525A (en)
KR (1) KR900702048A (en)
AU (1) AU4076589A (en)
DK (1) DK106690A (en)
FI (1) FI902152A0 (en)
GR (1) GR890100541A (en)
IL (1) IL91475A0 (en)
WO (1) WO1990002812A1 (en)
ZA (1) ZA896716B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0894141T1 (en) 1996-02-20 2005-10-31 Applied Research Systems Ars Holding N.V. Hybrid proteins which form heterodimers
US6361992B1 (en) 1996-05-08 2002-03-26 The United States Of America As Represented By The Department Of Health And Human Services Thyroid stimulating hormone superagonists
WO1997042322A1 (en) * 1996-05-08 1997-11-13 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Glycoprotein hormone superagonists
EP2880164B1 (en) 2012-07-30 2019-04-24 Trophogen Inc. Glycoprotein hormone long-acting superagonists
US10457713B2 (en) 2012-07-30 2019-10-29 Trophogen, Inc. Glycoprotein hormone long-acting superagonists
US10544200B2 (en) 2013-11-05 2020-01-28 Trophogen, Inc. Glycoprotein hormone long-acting superagonists
BR102016006222A2 (en) * 2016-03-22 2017-09-26 Universidade De São Paulo - Usp PROCESS OF PRODUCTION AND PURIFICATION OF RECOMBINANT HYDROGEN HYDROGEN HYBRID OR NON-HYBRID, RECOMBINANT HYDROGEN HYDROGEN OR NON-HYBRID, VECTORS OF EXPRESSION, AND USES OF RECOMBINANT HYBRID

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001958A1 (en) * 1983-11-02 1985-05-09 Reddy Vemuri B Production of heterodimeric human fertility hormones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001958A1 (en) * 1983-11-02 1985-05-09 Reddy Vemuri B Production of heterodimeric human fertility hormones

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
JOURNAL OF ENDOCRONOLOGY, vol. 115, 1987, pages 341-346, Journal of Endocronology Ltd, London, GB; F. STEWART et al.: "Nucleotide (cDNA) sequence encoding the horse gonado-trophine alpha-subunit" *
MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 40, 1985, pages 69-77, Elsevier Scientific Publishers Ireland, Ltd, Shannon, IR; G.R. BOUSFIELD et al.: "Hybrids from equine LH: alpha enhances, beta diminishes activity" *

Also Published As

Publication number Publication date
DK106690D0 (en) 1990-04-30
JPH03502525A (en) 1991-06-13
FI902152A7 (en) 1990-04-27
IL91475A0 (en) 1990-04-29
DK106690A (en) 1990-04-30
WO1990002812A1 (en) 1990-03-22
EP0386203A1 (en) 1990-09-12
ZA896716B (en) 1991-03-27
AU4076589A (en) 1990-04-02
KR900702048A (en) 1990-12-05
FI902152A0 (en) 1990-04-27

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