GR890100315A - Use of gonadoliberin derivatives for preparing tumour inhibiting pharmaceutical compositions - Google Patents
Use of gonadoliberin derivatives for preparing tumour inhibiting pharmaceutical compositionsInfo
- Publication number
- GR890100315A GR890100315A GR890100315A GR890100315A GR890100315A GR 890100315 A GR890100315 A GR 890100315A GR 890100315 A GR890100315 A GR 890100315A GR 890100315 A GR890100315 A GR 890100315A GR 890100315 A GR890100315 A GR 890100315A
- Authority
- GR
- Greece
- Prior art keywords
- group
- amino acid
- general type
- pharmaceutical
- amyloid
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000009165 Gonadoliberin Human genes 0.000 title 1
- 108050000048 Gonadoliberin Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002184 metal Chemical class 0.000 abstract 3
- 229910052751 metal Chemical class 0.000 abstract 3
- 150000008575 L-amino acids Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 235000009508 confectionery Nutrition 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 125000002435 L-phenylalanyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 abstract 1
- 206010047642 Vitiligo Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 208000035850 clinical syndrome Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 239000003941 gonadotropin derivative Substances 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000029522 neoplastic syndrome Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001982 tryptophyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
Η εφεύρεση αναφέρεται σε μία μέ?οδο παρασκευής φαρμακευτικών συν?έσεων που περιέχουν παράγωγο γκοναδολιμπερίνης του γενικού τύπου (I): GLP-HIS-TRP-SER-TYR-X1-X2-X3-PRO-X4 (I) όπου ταΧ1 είναι μία γλύκυλο ομάδα ή ένα D-ισομερές οιασδήποτε φύσης ή συν?ετική αρωματική ομάδα D-αμινο οξέωςΧ2 είναι μία L-αμινο οξέως ομάδα που φέρει μία C1-4 άλκυλο ή L-φαινυλαλάνυλο ή L-τρυπτόφυλο ομάδαΧ3 είναι ένα τμήμα L-αμινο οξέως που φέρει παράπλευρο άλυσσο ενός C1-4 ή C2-4 αλκανοϋλο αμιδίου - καιΧ4 σημαίνει ένα γλύκυλο αμίδιο ή μία C1-4 άλκυλο αμιδίου ομάδα, με την προϋπό?εση ότι το Χ3 σημαίνει μία ομάδα διαφορετική από λεύκυλο όταν το Χ2 είναι μία τρυπτόφυλο ομάδα και το Χ1 είναι οτιδήποτε εκτός από γλύκυλο ομάδα, τα προσ?έσεως αυτών άλατα που σχηματίζονται με φαρμακευτικώς αποδεκτά οξέα ή σύμπλοκα μετάλλου που περιλαμβάνει μείξη των ενώσεων του γενικού τύπου (1), τα οξίνης πρόσ?εσης άλατα ή σύμπλοκα μετάλλου, που παρασκευάσ?ηκαν κατά γνωστό τρόπο αυτά κα?' αυτά, με φορείς και/ή πρόσ?ετα, που χρησιμοποιούνται κοινά στη φαρμακευτική βιομηχανία και μετατροπή αυτών σε μία φαρμακευτική σύν?εση χρήσιμη για ?εραπεία όγκων, που εξαρτώνται από ορμόνη χωρίς την επιβολή οιοδήποτε ορμονικού ευνουχισμού.Ακόμη η εφεύρεση σχετίζεται με την χρήση παραγώγων γκοναδολιμπερίνης του γενικού τύπου (Ι) δια την παρασκευή φαρμακευτικών συν?έσεων που δρουν εναντίον όγκων που εξαρτώνται από ορμόνη και κλινικών συν?ηκών.ωThe invention refers to a method of preparation of pharmaceutical compounds containing general type gonadotropin derivative (I): GLP-HIS-TRP-SER-TYR-X1-X2-X2-X3-PRO-X4 (I) where x1 is one Licorice group or a D-isomer of any nature or synthetic aromatic group D-amino acid X2 is an L-amino acid group bearing a C1-4 alkyl or L-phenylalanyl or L-tryptophyl group X3 is a part of L-amino acid that carries a side chain of a C1-4 or C2-4 alkanoil amide - and X4 means a sweet amyloid or a C1-4 amyloid alkyl group, provided that X3 means a group other than vitiligo when X2 is a tryptophyl group and X1 is anything but a sweet group, the addition of these salts formed with drug-acceptable acids or metal complexes that involves mixing the compounds of the general type (1), the acid addition of metals or metal complexes, which were prepared in a well-known way and These, with carriers and / or additives commonly used in the pharmaceutical industry and their conversion into a pharmaceutical compound useful for treating tumors, which depend on the hormone without the imposition of any hormonal castration. The invention is still associated with use. gonadotropin-releasing derivatives of the general type (I) for the preparation of pharmaceutical compounds that act against hormone-dependent tumors and clinical syndromes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU882347A HU199694B (en) | 1988-05-10 | 1988-05-10 | Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR890100315A true GR890100315A (en) | 1990-03-12 |
Family
ID=10958948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR890100315A GR890100315A (en) | 1988-05-10 | 1989-05-10 | Use of gonadoliberin derivatives for preparing tumour inhibiting pharmaceutical compositions |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPH0215097A (en) |
| KR (1) | KR900017610A (en) |
| BE (1) | BE1004932A3 (en) |
| CH (1) | CH678013A5 (en) |
| DE (1) | DE3915317A1 (en) |
| DK (1) | DK228289A (en) |
| FI (1) | FI892275A (en) |
| FR (1) | FR2631237A1 (en) |
| GB (1) | GB2218335B (en) |
| GR (1) | GR890100315A (en) |
| HU (1) | HU199694B (en) |
| IL (1) | IL89998A0 (en) |
| IT (1) | IT1229251B (en) |
| LU (1) | LU87516A1 (en) |
| NL (1) | NL8901159A (en) |
| SE (1) | SE8901660L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760000A (en) * | 1994-05-13 | 1998-06-02 | University Technologies International,Inc. | Inhibition of liver cancer by the use of GnRH and GnRH analogs |
| US6054432A (en) * | 1996-09-12 | 2000-04-25 | Asta Medica Aktiengesellschaft | Means for treating prostate hypertrophy and prostate cancer |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
| FR2556970A1 (en) * | 1983-12-23 | 1985-06-28 | Koezponti Valto Hitelbank | PROCESS FOR OBTAINING SEXUAL PRODUCTS READY FOR FERTILIZATION FROM SEXUALLY MATURE FISH |
| GB2152059A (en) * | 1983-12-23 | 1985-07-31 | Koezponti Valto Hitelbank | Gonadoliberin derivatives |
| WO1986001105A1 (en) * | 1984-08-02 | 1986-02-27 | Fernand Labrie | Pharmaceutical composition for combination therapy of hormone dependent cancers |
| GB2179250A (en) * | 1985-07-18 | 1987-03-04 | Innofinance Altalanos Innovaci | Process for obtaining sexual products from mammals |
| GB2185025A (en) * | 1986-01-03 | 1987-07-08 | Innofinance Altalanos Innovaci | Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same |
| US4721775A (en) * | 1985-08-26 | 1988-01-26 | Board Of Regents, The University Of Texas System | Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids |
| US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
-
1988
- 1988-05-10 HU HU882347A patent/HU199694B/en active IP Right Revival
-
1989
- 1989-04-18 IL IL89998A patent/IL89998A0/en unknown
- 1989-05-08 CH CH1725/89A patent/CH678013A5/de not_active IP Right Cessation
- 1989-05-09 NL NL8901159A patent/NL8901159A/en not_active Application Discontinuation
- 1989-05-10 KR KR1019890006230A patent/KR900017610A/en not_active Application Discontinuation
- 1989-05-10 DK DK228289A patent/DK228289A/en not_active Application Discontinuation
- 1989-05-10 DE DE3915317A patent/DE3915317A1/en not_active Withdrawn
- 1989-05-10 BE BE8900499A patent/BE1004932A3/en not_active IP Right Cessation
- 1989-05-10 SE SE8901660A patent/SE8901660L/en not_active Application Discontinuation
- 1989-05-10 FI FI892275A patent/FI892275A/en not_active Application Discontinuation
- 1989-05-10 JP JP1115265A patent/JPH0215097A/en active Pending
- 1989-05-10 FR FR8906094A patent/FR2631237A1/en active Pending
- 1989-05-10 GR GR890100315A patent/GR890100315A/en unknown
- 1989-05-10 GB GB8910724A patent/GB2218335B/en not_active Expired - Fee Related
- 1989-05-10 LU LU87516A patent/LU87516A1/en unknown
- 1989-05-11 IT IT8920435A patent/IT1229251B/en active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
| FR2556970A1 (en) * | 1983-12-23 | 1985-06-28 | Koezponti Valto Hitelbank | PROCESS FOR OBTAINING SEXUAL PRODUCTS READY FOR FERTILIZATION FROM SEXUALLY MATURE FISH |
| GB2152059A (en) * | 1983-12-23 | 1985-07-31 | Koezponti Valto Hitelbank | Gonadoliberin derivatives |
| WO1986001105A1 (en) * | 1984-08-02 | 1986-02-27 | Fernand Labrie | Pharmaceutical composition for combination therapy of hormone dependent cancers |
| US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
| GB2179250A (en) * | 1985-07-18 | 1987-03-04 | Innofinance Altalanos Innovaci | Process for obtaining sexual products from mammals |
| US4721775A (en) * | 1985-08-26 | 1988-01-26 | Board Of Regents, The University Of Texas System | Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids |
| GB2185025A (en) * | 1986-01-03 | 1987-07-08 | Innofinance Altalanos Innovaci | Gonadoliberin derivatives containing an aromatic aminocarboxylic acid in the 6-position, pharmaceutical and veterinary compositions containing them and process for preparing same |
Non-Patent Citations (1)
| Title |
|---|
| CLAIMS SEARCHED: ALL * |
Also Published As
| Publication number | Publication date |
|---|---|
| HUT49813A (en) | 1989-11-28 |
| DE3915317A1 (en) | 1989-11-23 |
| HU199694B (en) | 1990-03-28 |
| IT1229251B (en) | 1991-07-26 |
| CH678013A5 (en) | 1991-07-31 |
| IL89998A0 (en) | 1989-12-15 |
| SE8901660L (en) | 1989-11-11 |
| SE8901660D0 (en) | 1989-05-10 |
| FI892275A0 (en) | 1989-05-10 |
| IT8920435A0 (en) | 1989-05-11 |
| JPH0215097A (en) | 1990-01-18 |
| GB2218335B (en) | 1991-09-25 |
| FR2631237A1 (en) | 1989-11-17 |
| GB8910724D0 (en) | 1989-06-28 |
| DK228289A (en) | 1989-11-11 |
| NL8901159A (en) | 1989-12-01 |
| GB2218335A (en) | 1989-11-15 |
| BE1004932A3 (en) | 1993-03-02 |
| FI892275A (en) | 1989-11-11 |
| KR900017610A (en) | 1990-12-19 |
| DK228289D0 (en) | 1989-05-10 |
| LU87516A1 (en) | 1990-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3689363D1 (en) | Pharmaceutical compositions for the treatment of metastases from cancer tumors. | |
| AU7565091A (en) | Use of copper(ii) containing compounds to accelerate wound healing | |
| FI941987L (en) | Novel amino acid derivatives, methods for their preparation and pharmaceutical compositions containing these compounds | |
| NL194165B (en) | Carbostyril derivatives, methods of preparation thereof and pharmaceutical compositions containing these derivatives. Derivatives of quinolonyl-2-aminocarboxylic acids and pharmaceutical preparations containing these derivatives. | |
| ATE87319T1 (en) | INCLUSION COMPLEXES OF 7-ISOPROPOXY-ISOFLAVONE WITH CYCLODEXTRINS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE INCLUSION COMPLEXES. | |
| GR1001550B (en) | Salts of peptides with carboxy-terminated polyesters | |
| CY1105683T1 (en) | ACANTHO-PORK PROTEIN CONVERTS, METHOD FOR PREPARATION AND USE THEREOF | |
| MX15387A (en) | PROCEDURE FOR THE PREPARATION ARILHIDRAZONAS, PRODUCT OBTAINED AND PHARMACEUTICAL PREPARATION THAT INCLUDES IT. | |
| AR011957A1 (en) | DOLASTATIN 15 DERIVATIVES WITH CARBONYL AND HETERO-CYCLICAL FUNCTIONALITIES IN THE C-TERMINAL | |
| KR960010683A (en) | Somatostatin peptide, its preparation and pharmaceutical composition containing the same | |
| ES2040206T3 (en) | PROCEDURE FOR PREPARING NEW TIAZOL COMPOUNDS. | |
| GR1000172B (en) | IMPROVEMENTS IN OR COMPLETE TO THE BODIES. | |
| SE8901041D0 (en) | ANTITROMOBOTIC PHARMACEUTICAL PREPARATIONS AND PROCEDURES FOR THEIR PREPARATION | |
| HU911928D0 (en) | Process for the production of chelates and its complexes containing orto ligating functional group, and the medical preparations containing thereof | |
| GR890100315A (en) | Use of gonadoliberin derivatives for preparing tumour inhibiting pharmaceutical compositions | |
| MY104829A (en) | 3-phenyl-5, 6-dihydrobenz [c]acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents. | |
| ES2039402T3 (en) | USE OF N, N'-BIS-L-AMINO ACID-L-CYSTINE PEPTIDES IN AMINO ACID PREPARATIONS FOR ORAL AND PARENTERAL FEEDING. | |
| SE8406554D0 (en) | NEW GONADOLIBERIN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | |
| ZA93275B (en) | Pseudopeptide compounds having bradykinin-antagonist activity, process for preparing them and pharmaceutical compositions containing them. | |
| ES2037003T3 (en) | PROCEDURE FOR PREPARING PEPTIDES USING PERCLORATES. | |
| DE59009479D1 (en) | Ibuprofen and S - (+) - Ibuprofen preparations and process for their preparation. | |
| AR011535A1 (en) | COMPOSITION OF MOUTH RINSES INCLUDING CHLORHEXIDINE AND POLYVINYLPYROLIDONE | |
| SE8804607D0 (en) | AQUEOS FORMALATIONS CONTAINING A PIPERIDINYLCYCLOPENTYLHEPTENOIC ACID DERIVATIVE | |
| ATE137487T1 (en) | COMPLEXES CONTAINING S(+)-PHENYL-ALKANOIC ACIDS AND ALPHA-HYDROXY-ALKANOIC ACIDS | |
| AT342761B (en) | PROCESS FOR THE PREPARATION OF HOMOPYRIMIDAZOLE DERIVATIVES CONTAINING STABLE PHARMACEUTICAL PREPARATIONS FOR ORAL ADMINISTRATION |