GR3034762T3 - Benzothiophene pharmaceutical compounds - Google Patents
Benzothiophene pharmaceutical compoundsInfo
- Publication number
- GR3034762T3 GR3034762T3 GR20000402451T GR20000402451T GR3034762T3 GR 3034762 T3 GR3034762 T3 GR 3034762T3 GR 20000402451 T GR20000402451 T GR 20000402451T GR 20000402451 T GR20000402451 T GR 20000402451T GR 3034762 T3 GR3034762 T3 GR 3034762T3
- Authority
- GR
- Greece
- Prior art keywords
- alkyl
- rdurule
- aryl
- compounds
- progestin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 239000000262 estrogen Substances 0.000 abstract 3
- 229940011871 estrogen Drugs 0.000 abstract 3
- 239000000583 progesterone congener Substances 0.000 abstract 3
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- XBQNZPDIRJPFAI-UHFFFAOYSA-N 3,3-dimethylpyrrolidine Chemical compound CC1(C)CCNC1 XBQNZPDIRJPFAI-UHFFFAOYSA-N 0.000 abstract 1
- RDEHRKLSYJBKDV-UHFFFAOYSA-N 3,4-dimethylpyrrolidine Chemical compound CC1CNCC1C RDEHRKLSYJBKDV-UHFFFAOYSA-N 0.000 abstract 1
- KYINPWAJIVTFBW-UHFFFAOYSA-N 3-methylpyrrolidine Chemical compound CC1CCNC1 KYINPWAJIVTFBW-UHFFFAOYSA-N 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010027304 Menopausal symptoms Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical group OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 229960004296 megestrol acetate Drugs 0.000 abstract 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940053934 norethindrone Drugs 0.000 abstract 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 abstract 1
- XSXHWVKGUXMUQE-UHFFFAOYSA-N osmium dioxide Inorganic materials O=[Os]=O XSXHWVKGUXMUQE-UHFFFAOYSA-N 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/402,415 US6395755B1 (en) | 1995-03-10 | 1995-03-10 | Benzothiophene pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3034762T3 true GR3034762T3 (en) | 2001-02-28 |
Family
ID=23591799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000402451T GR3034762T3 (en) | 1995-03-10 | 2000-11-07 | Benzothiophene pharmaceutical compounds |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6395755B1 (el) |
| EP (2) | EP0953568B1 (el) |
| JP (1) | JPH11501930A (el) |
| AT (2) | ATE195519T1 (el) |
| AU (1) | AU697502B2 (el) |
| BR (1) | BR9607775A (el) |
| CA (1) | CA2214261A1 (el) |
| DE (2) | DE69609748T2 (el) |
| DK (1) | DK0731100T3 (el) |
| ES (2) | ES2205702T3 (el) |
| GR (1) | GR3034762T3 (el) |
| IL (1) | IL117398A (el) |
| PT (1) | PT731100E (el) |
| SI (1) | SI0731100T1 (el) |
| WO (1) | WO1996028155A1 (el) |
| ZA (1) | ZA961883B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432982B1 (en) * | 1996-02-21 | 2002-08-13 | Eli Lilly And Company | Benzothiophenes, and formulations and methods using same |
| EP0801066A1 (en) * | 1996-03-12 | 1997-10-15 | Eli Lilly And Company | Heterocyclic substituted benzothiophenes and pharmaceutical compositions |
| CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
| CA2214196A1 (en) * | 1996-09-26 | 1998-03-26 | Eli Lilly And Company | Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods |
| CA2216592C (en) * | 1996-10-24 | 2006-07-18 | Brian Stephen Muehl | Benzothiophene compounds, intermediates, compositions, and methods |
| WO2002094788A1 (en) | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| EP1401446B1 (en) | 2001-05-22 | 2005-02-09 | Eli Lilly And Company | Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen |
| WO2003011282A1 (en) | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| ATE448215T1 (de) * | 2004-01-22 | 2009-11-15 | Lilly Co Eli | Selektive östrogen-rezeptor-modulatoren |
| GR1005694B (el) * | 2005-06-08 | 2007-10-22 | Αλεξης Μιχαηλ | Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
| US3947470A (en) | 1974-06-20 | 1976-03-30 | Smithkline Corporation | Substituted benzofurans and benzothiophenes |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| IT1154888B (it) * | 1980-11-12 | 1987-01-21 | Menarini Sas | Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| EP0062503A1 (en) * | 1981-04-03 | 1982-10-13 | Eli Lilly And Company | Benzothiophene compounds and process for preparing them |
| US4380635A (en) | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| IL65379A0 (en) * | 1981-04-03 | 1982-05-31 | Lilly Co Eli | Process for preparing acylated benzothiophenes |
| US4851554A (en) | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| WO1989002893A1 (en) * | 1987-09-30 | 1989-04-06 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzothiophene derivatives |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US5482949A (en) | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5523309A (en) * | 1995-03-10 | 1996-06-04 | Eli Lilly And Company | Benzofuran pharmaceutical compounds |
-
1995
- 1995-03-10 US US08/402,415 patent/US6395755B1/en not_active Expired - Fee Related
-
1996
- 1996-03-06 AT AT96301534T patent/ATE195519T1/de not_active IP Right Cessation
- 1996-03-06 PT PT96301534T patent/PT731100E/pt unknown
- 1996-03-06 DE DE69609748T patent/DE69609748T2/de not_active Expired - Fee Related
- 1996-03-06 DE DE69629500T patent/DE69629500T2/de not_active Expired - Fee Related
- 1996-03-06 EP EP99202800A patent/EP0953568B1/en not_active Expired - Lifetime
- 1996-03-06 ES ES99202800T patent/ES2205702T3/es not_active Expired - Lifetime
- 1996-03-06 EP EP96301534A patent/EP0731100B1/en not_active Expired - Lifetime
- 1996-03-06 DK DK96301534T patent/DK0731100T3/da active
- 1996-03-06 AT AT99202800T patent/ATE247100T1/de not_active IP Right Cessation
- 1996-03-06 SI SI9630256T patent/SI0731100T1/xx unknown
- 1996-03-06 ES ES96301534T patent/ES2148681T3/es not_active Expired - Lifetime
- 1996-03-07 AU AU53048/96A patent/AU697502B2/en not_active Ceased
- 1996-03-07 CA CA002214261A patent/CA2214261A1/en not_active Abandoned
- 1996-03-07 WO PCT/US1996/003164 patent/WO1996028155A1/en active Application Filing
- 1996-03-07 BR BR9607775A patent/BR9607775A/pt not_active Application Discontinuation
- 1996-03-07 IL IL11739896A patent/IL117398A/xx not_active IP Right Cessation
- 1996-03-07 ZA ZA9601883A patent/ZA961883B/xx unknown
- 1996-03-07 JP JP8527729A patent/JPH11501930A/ja active Pending
-
2000
- 2000-11-07 GR GR20000402451T patent/GR3034762T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2214261A1 (en) | 1996-09-19 |
| ATE247100T1 (de) | 2003-08-15 |
| ZA961883B (en) | 1997-09-08 |
| IL117398A (en) | 2000-11-21 |
| DE69609748D1 (de) | 2000-09-21 |
| ES2205702T3 (es) | 2004-05-01 |
| AU5304896A (en) | 1996-10-02 |
| EP0731100A1 (en) | 1996-09-11 |
| DE69629500D1 (de) | 2003-09-18 |
| EP0731100B1 (en) | 2000-08-16 |
| SI0731100T1 (en) | 2001-02-28 |
| AU697502B2 (en) | 1998-10-08 |
| DE69609748T2 (de) | 2001-04-12 |
| EP0953568B1 (en) | 2003-08-13 |
| BR9607775A (pt) | 1998-07-07 |
| DK0731100T3 (da) | 2000-09-18 |
| PT731100E (pt) | 2001-01-31 |
| EP0953568A1 (en) | 1999-11-03 |
| MX9706737A (es) | 1997-11-29 |
| ATE195519T1 (de) | 2000-09-15 |
| DE69629500T2 (de) | 2004-07-01 |
| IL117398A0 (en) | 1996-07-23 |
| US6395755B1 (en) | 2002-05-28 |
| JPH11501930A (ja) | 1999-02-16 |
| ES2148681T3 (es) | 2000-10-16 |
| WO1996028155A1 (en) | 1996-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |