GR3033836T3 - -g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

-g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: GR3033836T3
Authority: GR; Greece
Prior art keywords: substd; opt; nhcoocme3; substits; succinyl
Prior art date: 1993-06-11

Application number

GR20000401537T

Other languages

English (en)

Inventor

Robert C Kelly

Roy A Johnson

Harvey I Skulnick

Eldon G Nidy

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-11

Filing date

2000-06-30

Publication date

2000-10-31

1993-12-13 Priority claimed from PCT/US1993/011827 external-priority patent/WO1994013655A1/en

2000-06-30 Application filed by Upjohn Co filed Critical Upjohn Co

2000-10-31 Publication of GR3033836T3 publication Critical patent/GR3033836T3/el

Links

230000000118 anti-neoplastic effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
-1 amino, p-toluene-sulphonamido Chemical group 0.000 abstract 5
150000007513 acids Chemical class 0.000 abstract 3
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
KNWCDYSKJSREAQ-UHFFFAOYSA-N 1,3-oxazolidine-2-carboxylic acid Chemical class OC(=O)C1NCCO1 KNWCDYSKJSREAQ-UHFFFAOYSA-N 0.000 abstract 1
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 abstract 1
SBQWITJAJITAMM-UHFFFAOYSA-N 4-oxo-4-(2-sulfoethylamino)butanoic acid Chemical compound OC(=O)CCC(=O)NCCS(O)(=O)=O SBQWITJAJITAMM-UHFFFAOYSA-N 0.000 abstract 1
101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002905 alkanoylamido group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005281 alkyl ureido group Chemical group 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
150000003935 benzaldehydes Chemical class 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000020176 deacylation Effects 0.000 abstract 1
238000005947 deacylation reaction Methods 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR20000401537T 1993-06-11 2000-06-30 -g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GR3033836T3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US7633793A	1993-06-11	1993-06-11
US12297493A	1993-09-17	1993-09-17
PCT/US1993/011827 WO1994013655A1 (en)	1992-12-15	1993-12-13	7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/US1994/006035 WO1994029288A1 (en)	1993-06-11	1994-06-03	Δ6,7-taxols antineoplastic use and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
GR3033836T3 true GR3033836T3 (en)	2000-10-31

Family

ID=26757982

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20000401537T GR3033836T3 (en)	1993-06-11	2000-06-30	-g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (18)

Country	Link
US (2)	US5965739A (el)
EP (3)	EP0703909B1 (el)
JP (1)	JPH09511212A (el)
AT (3)	ATE192147T1 (el)
AU (1)	AU7138894A (el)
CA (1)	CA2161328A1 (el)
DE (3)	DE69424166T2 (el)
DK (3)	DK0982301T3 (el)
ES (3)	ES2219968T3 (el)
GR (1)	GR3033836T3 (el)
IL (1)	IL109957A (el)
LV (2)	LV12692B (el)
NZ (2)	NZ268475A (el)
PT (3)	PT982301E (el)
SI (2)	SI0982302T1 (el)
TW (1)	TW401407B (el)
WO (1)	WO1994029288A1 (el)
ZA (1)	ZA944034B (el)

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CN111138386A (zh) *	2019-12-30	2020-05-12	重庆市碚圣医药科技股份有限公司	一种多西他赛的半合成方法
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US5157049A (en) *	1988-03-07	1992-10-20	The United States Of America As Represented By The Department Of Health & Human Services	Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
EP0366841A1 (en) *	1988-11-03	1990-05-09	Dresser-Rand Company	A crosshead and crosshead pin coupling arrangement
US4960790A (en) *	1989-03-09	1990-10-02	University Of Kansas	Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
IL95436A (en) *	1989-08-23	1996-07-23	Centre Nat Rech Scient	Process for preparing the history of phenylisosarine
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
FR2658513B1 (fr) *	1990-02-21	1994-02-04	Rhone Poulenc Sante	Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2658510B1 (fr) *	1990-02-21	1992-04-30	Rhone Poulenc Sante	Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2662440B1 (fr) *	1990-05-22	1992-07-31	Rhone Poulenc Sante	Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) *	1990-05-22	1992-10-23	Rhone Poulenc Sante	Procede de preparation enantioselective de derives de la phenylisoserine.
US5059699A (en) *	1990-08-28	1991-10-22	Virginia Tech Intellectual Properties, Inc.	Water soluble derivatives of taxol
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2679230B1 (fr) *	1991-07-16	1993-11-19	Rhone Poulenc Rorer Sa	Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
FR2687151B1 (fr) *	1992-02-07	1994-03-25	Rhone Poulenc Rorer Sa	Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5248796A (en) *	1992-06-18	1993-09-28	Bristol-Myers Squibb Company	Taxol derivatives
ES2211861T3 (es) *	1992-07-01	2004-07-16	Bristol-Myers Squibb Company	7,8-ciclopropataxanos de accion antitumoral.
US5294637A (en) *	1992-07-01	1994-03-15	Bristol-Myers Squibb Company	Fluoro taxols
US5254580A (en) *	1993-01-19	1993-10-19	Bristol-Myers Squibb Company	7,8-cyclopropataxanes
FR2696464B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
FR2697522B1 (fr) *	1992-10-30	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
CA2109861C (en) *	1992-12-04	1999-03-16	Shu-Hui Chen	6,7-modified paclitaxels
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
FR2698871B1 (fr) *	1992-12-09	1995-02-24	Rhone Poulenc Rorer Sa	Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.

1994
- 1994-06-03 AT AT94920688T patent/ATE192147T1/de not_active IP Right Cessation
- 1994-06-03 US US08/557,034 patent/US5965739A/en not_active Expired - Fee Related
- 1994-06-03 JP JP7501878A patent/JPH09511212A/ja not_active Ceased
- 1994-06-03 AT AT99118034T patent/ATE264316T1/de not_active IP Right Cessation
- 1994-06-03 SI SI9430464T patent/SI0982302T1/xx unknown
- 1994-06-03 ES ES99118034T patent/ES2219968T3/es not_active Expired - Lifetime
- 1994-06-03 DK DK99118033T patent/DK0982301T3/da active
- 1994-06-03 EP EP94920688A patent/EP0703909B1/en not_active Expired - Lifetime
- 1994-06-03 NZ NZ268475A patent/NZ268475A/en unknown
- 1994-06-03 PT PT99118033T patent/PT982301E/pt unknown
- 1994-06-03 EP EP99118033A patent/EP0982301B1/en not_active Expired - Lifetime
- 1994-06-03 DE DE69424166T patent/DE69424166T2/de not_active Expired - Fee Related
- 1994-06-03 PT PT94920688T patent/PT703909E/pt unknown
- 1994-06-03 PT PT99118034T patent/PT982302E/pt unknown
- 1994-06-03 AT AT99118033T patent/ATE249448T1/de not_active IP Right Cessation
- 1994-06-03 DE DE69433715T patent/DE69433715T2/de not_active Expired - Fee Related
- 1994-06-03 DK DK94920688T patent/DK0703909T3/da active
- 1994-06-03 WO PCT/US1994/006035 patent/WO1994029288A1/en active IP Right Grant
- 1994-06-03 NZ NZ330671A patent/NZ330671A/xx unknown
- 1994-06-03 CA CA002161328A patent/CA2161328A1/en not_active Abandoned
- 1994-06-03 ES ES99118033T patent/ES2205663T3/es not_active Expired - Lifetime
- 1994-06-03 AU AU71388/94A patent/AU7138894A/en not_active Abandoned
- 1994-06-03 DE DE69433146T patent/DE69433146T2/de not_active Expired - Fee Related
- 1994-06-03 SI SI9430317T patent/SI0703909T1/xx unknown
- 1994-06-03 ES ES94920688T patent/ES2145829T3/es not_active Expired - Lifetime
- 1994-06-03 EP EP99118034A patent/EP0982302B1/en not_active Expired - Lifetime
- 1994-06-03 DK DK99118034T patent/DK0982302T3/da active
- 1994-06-08 ZA ZA944034A patent/ZA944034B/xx unknown
- 1994-06-09 TW TW083105245A patent/TW401407B/zh not_active IP Right Cessation
- 1994-06-09 IL IL10995794A patent/IL109957A/en not_active IP Right Cessation
- 1994-06-10 US US08/258,019 patent/US5556878A/en not_active Expired - Fee Related
2000
- 2000-06-30 GR GR20000401537T patent/GR3033836T3/el not_active IP Right Cessation
2001
- 2001-04-26 LV LV010064A patent/LV12692B/xx unknown
2005
- 2005-04-14 LV LVP-05-45A patent/LV13319B/en unknown

Also Published As

Publication number	Publication date
SI0703909T1 (en)	2000-08-31
DE69424166T2 (de)	2000-10-05
EP0982302A3 (en)	2000-07-19
DE69433146D1 (de)	2003-10-16
DE69433715T2 (de)	2005-03-24
EP0703909B1 (en)	2000-04-26
EP0982301A3 (en)	2000-11-08
TW401407B (en)	2000-08-11
ES2145829T3 (es)	2000-07-16
ATE264316T1 (de)	2004-04-15
US5965739A (en)	1999-10-12
DK0982302T3 (da)	2004-08-02
LV13319B (en)	2005-08-20
EP0982301B1 (en)	2003-09-10
EP0703909A1 (en)	1996-04-03
DE69433715D1 (de)	2004-05-19
LV12692B (lv)	2001-09-20
DE69424166D1 (de)	2000-05-31
DE69433146T2 (de)	2004-06-09
PT982301E (pt)	2004-02-27
ES2205663T3 (es)	2004-05-01
ATE249448T1 (de)	2003-09-15
WO1994029288A1 (en)	1994-12-22
PT982302E (pt)	2004-07-30
NZ330671A (en)	2000-01-28
EP0982302A2 (en)	2000-03-01
PT703909E (pt)	2000-10-31
ATE192147T1 (de)	2000-05-15
NZ268475A (en)	1998-08-26
EP0982302B1 (en)	2004-04-14
IL109957A (en)	2001-01-11
CA2161328A1 (en)	1994-12-22
ES2219968T3 (es)	2004-12-01
JPH09511212A (ja)	1997-11-11
LV12692A (lv)	2001-07-20
EP0982301A2 (en)	2000-03-01
US5556878A (en)	1996-09-17
ZA944034B (en)	1995-12-08
DK0982301T3 (da)	2003-12-08
IL109957A0 (en)	1994-10-07
DK0703909T3 (da)	2000-09-11
AU7138894A (en)	1995-01-03
SI0982302T1 (en)	2004-08-31

Publication	Publication Date	Title
GR3033836T3 (en)	2000-10-31	-g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SE9102462D0 (sv)	1991-08-28	New isosteric peptides
DE69228627D1 (de)	1999-04-22	Langkettiger Carbonsäureimidester
AU2505297A (en)	1997-10-29	Acylated N-hydroxymethyl thalidomide prodrugs having an immunomodulatory effect
MY111814A (en)	2001-01-31	Watersoluble azole antifungals
MY102219A (en)	1992-05-15	Leukotriene antagonists
FI905943A0 (fi)	1990-12-03	Isotinderivat, deras framstaellning och anvaendning.
MY129537A (en)	2007-04-30	Amino acid ester containing azole antifungals
ATE133686T1 (de)	1996-02-15	Peptid-antibiotika
SG58291G (en)	1991-08-23	Anticonvulsant agents
DK215886D0 (da)	1986-05-09	1,3-oxathianderivater
JPS56142260A (en)	1981-11-06	2-azetidinone and its preparation
ATE95172T1 (de)	1993-10-15	Cyclopropanthiocarbonsaeureamide.
JPS5731648A (en)	1982-02-20	Pentapeptide derivative
NO20004774D0 (no)	2000-09-25	Alifatiske aminokarboksyl- og aminofosfonsyrer, aminonitriler og aminotetrazoler som cellulære redningsmidler
TH50956A3 (th)	2002-05-10	อนุพันธ์ฟีนิลไกลซีน

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