GR3030468T3 - Novel amidine derivatives, their preparation and their use as mediaments with ltb-4 antagonistic effect. - Google Patents

Novel amidine derivatives, their preparation and their use as mediaments with ltb-4 antagonistic effect.

Info

Publication number: GR3030468T3
Authority: GR; Greece
Prior art keywords: alkyl; alkoxy; halogen; formula; substd
Prior art date: 1992-02-05

Application number

GR990401541T

Other languages

English (en)

Inventor

Ralf Anderskewitz

Kurt Schromm

Ernst-Otto Renth

Frank Himmelsbach

Franz Birke

Armin Fuegner

Original Assignee

Boehringer Ingelheim Int

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-05

Filing date

1999-06-09

Publication date

1999-10-29

1992-02-05 Priority claimed from DE4203201A external-priority patent/DE4203201A1/de

1992-07-23 Priority claimed from DE4224289A external-priority patent/DE4224289A1/de

1992-12-24 Priority claimed from DE4244241A external-priority patent/DE4244241A1/de

1999-06-09 Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Int

1999-10-29 Publication of GR3030468T3 publication Critical patent/GR3030468T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)

GR990401541T 1992-02-05 1999-06-09 Novel amidine derivatives, their preparation and their use as mediaments with ltb-4 antagonistic effect. GR3030468T3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4203201A DE4203201A1 (de)	1992-02-05	1992-02-05	Neue amidinderivate, ihre herstellung und verwendung
DE4224289A DE4224289A1 (de)	1992-07-23	1992-07-23	Neue Amidinderivate, ihre Herstellung und Verwendung
DE4244241A DE4244241A1 (de)	1992-12-24	1992-12-24	Neue Verbindungen, ihre Herstellung und ihre Verwendung
PCT/EP1993/000070 WO1993016036A1 (de)	1992-02-05	1993-01-14	Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonischer wirkung

Publications (1)

Publication Number	Publication Date
GR3030468T3 true GR3030468T3 (en)	1999-10-29

Family

ID=27203364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990401541T GR3030468T3 (en)	1992-02-05	1999-06-09	Novel amidine derivatives, their preparation and their use as mediaments with ltb-4 antagonistic effect.

Country Status (29)

Country	Link
US (3)	US6037377A (el)
EP (2)	EP0902013B1 (el)
JP (2)	JP3487851B2 (el)
KR (1)	KR0163222B1 (el)
AT (2)	ATE180770T1 (el)
AU (1)	AU673343B2 (el)
CA (2)	CA2427890A1 (el)
CZ (2)	CZ287209B6 (el)
DE (2)	DE59309630D1 (el)
DK (2)	DK0625138T3 (el)
ES (2)	ES2132216T3 (el)
FI (1)	FI943618L (el)
GR (1)	GR3030468T3 (el)
HR (1)	HRP930102B1 (el)
HU (1)	HU216191B (el)
IL (1)	IL104589A0 (el)
MX (1)	MX9300630A (el)
NO (1)	NO301540B1 (el)
NZ (1)	NZ246593A (el)
PL (2)	PL173789B1 (el)
PT (1)	PT902013E (el)
RU (1)	RU2124002C1 (el)
SG (1)	SG44837A1 (el)
SI (1)	SI9300066B (el)
SK (1)	SK281016B6 (el)
TW (1)	TW232005B (el)
UA (1)	UA43318C2 (el)
WO (1)	WO1993016036A1 (el)
YU (1)	YU49038B (el)

Families Citing this family (36)

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US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
US5488160A (en) *	1991-06-11	1996-01-30	Ciba-Geigy Corporation	Amidino compounds, their manufacture and method of treatment
US5455274A (en) *	1992-12-09	1995-10-03	Ciba-Geigy Corporation	Hydroxyamidine derivatives
DE4309285A1 (de) *	1993-03-23	1994-09-29	Boehringer Ingelheim Kg	Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
DE4424714A1 (de) *	1994-07-13	1996-01-18	Boehringer Ingelheim Kg	Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff
DE4424713A1 (de) *	1994-07-13	1996-01-18	Boehringer Ingelheim Kg	Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE19546452A1 (de) *	1995-12-13	1997-06-19	Boehringer Ingelheim Kg	Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
PT883405E (pt)	1995-12-29	2004-06-30	Dimensional Pharm Inc	Inibidores de amidino-protease
US5942544A (en) *	1996-02-22	1999-08-24	Dupont Pharmaceuticals Company	α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19636689A1 (de) *	1996-09-10	1998-03-12	Boehringer Ingelheim Kg	Neue Benzamidinderivate
DE19637123A1 (de) *	1996-09-12	1998-03-19	Boehringer Ingelheim Kg	Neue Pyranosidderivate
CA2265996A1 (en) *	1996-09-26	1998-04-02	Roger Aki Fujimoto	Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
PL194329B1 (pl)	1997-05-14	2007-05-31	Atherogenics Inc	Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US5872122A (en) *	1997-10-16	1999-02-16	Monsanto Company	Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation
ID24720A (id)	1997-12-12	2000-08-03	Novartis Ag	Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
AU758771B2 (en) *	1997-12-23	2003-03-27	Merck Sharp & Dohme Corp.	Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine
US6291514B1 (en)	1998-02-09	2001-09-18	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
DE19948428A1 (de) *	1999-10-07	2001-04-12	Boehringer Ingelheim Pharma	Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel
FR2801053B1 (fr) *	1999-11-16	2004-06-25	Sod Conseils Rech Applic	Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments
US6528491B2 (en) *	2000-10-24	2003-03-04	Boehringer Ingelheim Pharma Kg	Pyranoside derivatives
DE10052333A1 (de) *	2000-10-24	2002-05-02	Boehringer Ingelheim Pharma	Neue Sulfooxybenzamide
AU2002320025A1 (en) *	2001-04-11	2002-11-11	Atherogenics, Inc.	Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US20030119901A1 (en) *	2001-07-14	2003-06-26	Boehringer Ingelheim Pharma Kg	Pharmaceutical formulation containing an LTB4 antagonist
JP2005502630A (ja) *	2001-07-14	2005-01-27	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	Ｌｔｂ４拮抗薬を含有する医薬製剤
KR20040036908A (ko) *	2001-08-31	2004-05-03	뉴로겜 인터내셔널 리미티드	아밀로이드증 치료용 아미딘 유도체
US20060229335A1 (en) *	2002-12-24	2006-10-12	Bradley Teegarden	Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a
EP1493739A1 (fr) *	2003-07-03	2005-01-05	Warner-Lambert Company LLC	Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US7262223B2 (en)	2004-01-23	2007-08-28	Neurochem (International) Limited	Amidine derivatives for treating amyloidosis
GB2445920A (en) *	2007-01-25	2008-07-30	Mucokinetica Ltd	Amidino compounds for treatment of respiratory disease
US8252840B2 (en) *	2007-03-26	2012-08-28	Salutria Pharmaceuticals Llc	Methods of derivatives of probucol for the treatment of type II diabetes
US20080280985A1 (en) *	2007-03-27	2008-11-13	Scott Robert A D	Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
WO2010068794A2 (en)	2008-12-10	2010-06-17	The General Hospital Corporation	Hif inhibitors and use thereof
TW201444798A (zh)	2013-02-28	2014-12-01	必治妥美雅史谷比公司	作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
US9828345B2 (en)	2013-02-28	2017-11-28	Bristol-Myers Squibb Company	Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
EP3886854A4 (en)	2018-11-30	2022-07-06	Nuvation Bio Inc.	PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THERE

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US4889871A (en) *	1987-05-29	1989-12-26	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
AU626033B2 (en) *	1988-10-25	1992-07-23	Government Of The United States Of America, As Represented By The Secretary Of The Army, The	Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
US5246965A (en) *	1991-06-11	1993-09-21	Ciba-Geigy	Arylethers, their manufacture and methods of treatment
DK0518819T3 (da) *	1991-06-11	1995-09-25	Ciba Geigy Ag	Amidino-forbindelser, deres fremstilling og anvendelse som lægemiddel
US5424334A (en) *	1991-12-19	1995-06-13	G. D. Searle & Co.	Peptide mimetic compounds useful as platelet aggregation inhibitors

1993
- 1993-01-14 AT AT93902195T patent/ATE180770T1/de not_active IP Right Cessation
- 1993-01-14 RU RU94041836A patent/RU2124002C1/ru not_active IP Right Cessation
- 1993-01-14 UA UA94095773A patent/UA43318C2/uk unknown
- 1993-01-14 CA CA002427890A patent/CA2427890A1/en not_active Abandoned
- 1993-01-14 PL PL93304713A patent/PL173789B1/pl unknown
- 1993-01-14 DE DE59309630T patent/DE59309630D1/de not_active Expired - Fee Related
- 1993-01-14 EP EP98121305A patent/EP0902013B1/de not_active Expired - Lifetime
- 1993-01-14 PT PT98121305T patent/PT902013E/pt unknown
- 1993-01-14 NZ NZ246593A patent/NZ246593A/en unknown
- 1993-01-14 AT AT98121305T patent/ATE210634T1/de not_active IP Right Cessation
- 1993-01-14 JP JP51370193A patent/JP3487851B2/ja not_active Expired - Fee Related
- 1993-01-14 PL PL93316750A patent/PL173781B1/pl unknown
- 1993-01-14 CA CA002129526A patent/CA2129526A1/en not_active Abandoned
- 1993-01-14 ES ES93902195T patent/ES2132216T3/es not_active Expired - Lifetime
- 1993-01-14 SK SK914-94A patent/SK281016B6/sk unknown
- 1993-01-14 HU HU9402291A patent/HU216191B/hu not_active IP Right Cessation
- 1993-01-14 AU AU33497/93A patent/AU673343B2/en not_active Ceased
- 1993-01-14 DK DK93902195T patent/DK0625138T3/da active
- 1993-01-14 DE DE59310252T patent/DE59310252D1/de not_active Expired - Fee Related
- 1993-01-14 EP EP93902195A patent/EP0625138B1/de not_active Expired - Lifetime
- 1993-01-14 WO PCT/EP1993/000070 patent/WO1993016036A1/de active Application Filing
- 1993-01-14 CZ CZ19941886A patent/CZ287209B6/cs unknown
- 1993-01-14 KR KR1019940702669A patent/KR0163222B1/ko not_active Expired - Fee Related
- 1993-01-14 SG SG1996008431A patent/SG44837A1/en unknown
- 1993-01-14 DK DK98121305T patent/DK0902013T3/da active
- 1993-01-14 ES ES98121305T patent/ES2165122T3/es not_active Expired - Lifetime
- 1993-01-29 TW TW082100562A patent/TW232005B/zh active
- 1993-02-03 YU YU6393A patent/YU49038B/sh unknown
- 1993-02-03 HR HRP4244241.9A patent/HRP930102B1/xx not_active IP Right Cessation
- 1993-02-03 IL IL104589A patent/IL104589A0/xx not_active IP Right Cessation
- 1993-02-04 MX MX9300630A patent/MX9300630A/es not_active IP Right Cessation
- 1993-02-05 SI SI9300066A patent/SI9300066B/sl not_active IP Right Cessation
1994
- 1994-08-04 FI FI943618A patent/FI943618L/fi unknown
- 1994-08-04 NO NO942903A patent/NO301540B1/no not_active IP Right Cessation
1995
- 1995-06-05 US US08/460,961 patent/US6037377A/en not_active Expired - Lifetime
1997
- 1997-04-18 CZ CZ19971203A patent/CZ287173B6/cs unknown
1999
- 1999-06-09 GR GR990401541T patent/GR3030468T3/el unknown
2000
- 2000-01-18 US US09/484,073 patent/US6489365B1/en not_active Expired - Lifetime
2002
- 2002-03-18 JP JP2002073593A patent/JP2002322143A/ja active Pending
- 2002-09-23 US US10/252,976 patent/US20030130232A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL104589A0 (en)	1993-06-10
ATE180770T1 (de)	1999-06-15
NO942903L (no)	1994-10-03
HU9402291D0 (en)	1994-10-28
TW232005B (el)	1994-10-11
YU6393A (sh)	1996-10-09
JP2002322143A (ja)	2002-11-08
PT902013E (pt)	2002-06-28
EP0902013B1 (de)	2001-12-12
UA43318C2 (uk)	2001-12-17
DK0902013T3 (da)	2002-03-25
SK281016B6 (sk)	2000-10-09
DE59309630D1 (de)	1999-07-08
PL173789B1 (pl)	1998-04-30
HRP930102A2 (en)	1998-12-31
US20030130232A1 (en)	2003-07-10
RU94041836A (ru)	1997-02-20
YU49038B (sh)	2003-07-07
FI943618A0 (fi)	1994-08-04
HU216191B (hu)	1999-05-28
CA2129526A1 (en)	1993-08-06
ATE210634T1 (de)	2001-12-15
KR0163222B1 (ko)	1999-01-15
CZ287209B6 (en)	2000-10-11
FI943618L (fi)	1994-08-04
JP3487851B2 (ja)	2004-01-19
EP0625138A1 (de)	1994-11-23
US6489365B1 (en)	2002-12-03
HUT68419A (en)	1995-06-28
CA2427890A1 (en)	1993-08-19
US6037377A (en)	2000-03-14
NO942903D0 (el)	1994-08-04
SI9300066B (sl)	2003-02-28
ES2132216T3 (es)	1999-08-16
JPH07503718A (ja)	1995-04-20
SG44837A1 (en)	1997-12-19
PL173781B1 (pl)	1998-04-30
SI9300066A (en)	1993-09-30
NZ246593A (en)	1997-07-27
KR950700241A (ko)	1995-01-16
CZ287173B6 (cs)	2000-10-11
DK0625138T3 (da)	1999-11-15
DE59310252D1 (de)	2002-01-24
EP0902013A1 (de)	1999-03-17
NO301540B1 (no)	1997-11-10
SK91494A3 (en)	1995-02-08
CZ188694A3 (en)	1995-03-15
WO1993016036A1 (de)	1993-08-19
EP0625138B1 (de)	1999-06-02
RU2124002C1 (ru)	1998-12-27
AU3349793A (en)	1993-09-03
HRP930102B1 (en)	2000-02-29
MX9300630A (es)	1993-09-01
ES2165122T3 (es)	2002-03-01
AU673343B2 (en)	1996-11-07

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