EP0656789B1
(en)
*
|
1992-08-21 |
1997-12-17 |
Genentech, Inc. |
Method for treating a lfa-1-mediated disorder
|
FR2700471B1
(fr)
*
|
1993-01-21 |
1995-04-07 |
Pasteur Merieux Serums Vacc |
Utilisation d'anticorps monoclonaux anti-LFA-1 pour la préparation d'un médicament destiné à prévenir le rejet des greffes d'organes solides et médicaments obtenus.
|
US5681699A
(en)
*
|
1994-02-11 |
1997-10-28 |
Cedars-Sinai Medical Center |
Methods of diagnosing ulcerative colitis and Crohn's disease
|
US6884590B1
(en)
|
1994-02-11 |
2005-04-26 |
Cedars-Sinai Medical Center |
Methods of screening for ulcerative colitis and crohn's disease
|
US6576236B1
(en)
*
|
1994-07-01 |
2003-06-10 |
Dana Farber Cancer Institute |
Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
|
US20020127201A1
(en)
*
|
1994-07-01 |
2002-09-12 |
Dana-Farber Cancer Institute. |
Methods for inhibiting T cell responses by manipulating a common cytokine receptor gamma-chain
|
EP0831907A4
(en)
*
|
1995-06-06 |
2005-05-04 |
D Allen Allen |
METHOD FOR TREATING MOLLUSCUM CONTAGIOSUM AS A RESULT OF HIV INFECTION
|
US20040197326A1
(en)
*
|
1995-07-27 |
2004-10-07 |
Genentech, Inc. |
Method for treatment of allergic asthma
|
US5914112A
(en)
*
|
1996-01-23 |
1999-06-22 |
Genentech, Inc. |
Anti-CD18 antibodies in stroke
|
AU5140196A
(en)
*
|
1996-03-29 |
1997-10-22 |
Universite Laval |
Method of restoring a functional protein in a tissue by cell transplantation
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
FR2763072B1
(fr)
*
|
1997-05-12 |
1999-11-05 |
Pasteur Merieux Serums Vacc |
Utilisation d'un anticorps monoclonal anti-lfa1 en transplantation renale
|
IL132882A0
(en)
*
|
1997-05-17 |
2001-03-19 |
Biogen Inc |
Use of a cd40:cd154 binding interruptor to prevent counter adaptive immune responses particularly graft rejection
|
US6172213B1
(en)
*
|
1997-07-02 |
2001-01-09 |
Genentech, Inc. |
Anti-IgE antibodies and method of improving polypeptides
|
WO2000029431A1
(en)
*
|
1998-11-17 |
2000-05-25 |
Tanox, Inc. |
Bispecific molecules cross-linking itim and itam for therapy
|
US6867203B2
(en)
|
1998-12-29 |
2005-03-15 |
Abbott Laboratories |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
|
US6582698B1
(en)
*
|
1999-03-19 |
2003-06-24 |
Genentech, Inc. |
Treatment method
|
EP1163003B1
(en)
*
|
1999-03-19 |
2009-08-12 |
Genentech, Inc. |
Treatment of lfa-1 associated disorders with increasing doses of lfa-1 antagonist
|
CN1409639A
(zh)
*
|
1999-12-14 |
2003-04-09 |
杰南技术公司 |
应用TNF-α拮抗剂和LFA-1拮抗剂治疗LFA-1或TNF-α介导的疾病
|
WO2001051084A1
(en)
*
|
2000-01-14 |
2001-07-19 |
Genentech, Inc. |
Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1
|
WO2001070266A2
(en)
|
2000-03-17 |
2001-09-27 |
Millennium Pharmaceuticals, Inc. |
Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2
|
WO2002018583A2
(en)
|
2000-09-01 |
2002-03-07 |
The Center For Blood Research, Inc. |
Modified polypeptides stabilized in a desired conformation and methods for producing same
|
EP2270188A3
(en)
|
2001-06-22 |
2011-09-07 |
Pioneer Hi-Bred International, Inc. |
Defensin polynucleotides and methods of use
|
EP1472275B1
(en)
|
2002-02-05 |
2008-12-17 |
Genentech, Inc. |
Protein purification
|
HUE025101T2
(en)
*
|
2002-04-26 |
2016-02-29 |
Genentech Inc |
Purification of proteins other than affinity purification
|
AU2004209638B2
(en)
|
2003-02-01 |
2011-02-03 |
Tanox, Inc. |
High affinity anti-human IgE antibodies
|
US7834147B2
(en)
|
2003-04-28 |
2010-11-16 |
Childrens Hospital Medical Center |
Saposin C-DOPS: a novel anti-tumor agent
|
HUE050171T2
(hu)
|
2003-07-28 |
2020-11-30 |
Genentech Inc |
Protein-A kioldódásának csökkentése protein-A affinitáskromatográfia során
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
JP5105578B2
(ja)
|
2003-11-05 |
2012-12-26 |
サーコード バイオサイエンス インコーポレイテッド |
細胞接着のモジュレーター
|
EP1697543B1
(en)
|
2003-11-21 |
2014-08-20 |
ANP Technologies, Inc. |
Asymmetrically branched polymer conjugates and microarray assays
|
CA2563432A1
(en)
*
|
2004-04-16 |
2005-12-01 |
Genentech, Inc. |
Method for augmenting b cell depletion
|
BRPI0511305A
(pt)
*
|
2004-06-09 |
2007-12-04 |
Genentech Inc |
método de aliviar um granuloma anular ou sarcóide, artigo manufaturado e uso de um antagonista de lfa-1
|
US7655229B2
(en)
*
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
CA2577405A1
(en)
*
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Anti-fc-gamma riib receptor antibody and uses therefor
|
US7662926B2
(en)
*
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
DE102004059357B8
(de)
*
|
2004-12-03 |
2009-12-03 |
Universität Leipzig |
Antikörper, welcher die Interaktion von humanem Thy-1 und dessen Liganden blockiert, sowie dessen Verwendung
|
EP2208998A3
(en)
|
2005-05-02 |
2011-03-16 |
ANP Technologies, Inc. |
Polymer conjugate enhanced bioassays
|
PL2444079T3
(pl)
|
2005-05-17 |
2017-07-31 |
Sarcode Bioscience Inc. |
Kompozycje i sposoby leczenia chorób oczu
|
US20080279848A1
(en)
*
|
2006-03-16 |
2008-11-13 |
Genentech, Inc. |
Methods of treating lupus using CD4 antibodies
|
JP2009530290A
(ja)
*
|
2006-03-16 |
2009-08-27 |
ジェネンテック・インコーポレーテッド |
Cd4抗体を使用するループスの治療方法
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
WO2008011081A2
(en)
|
2006-07-19 |
2008-01-24 |
The Trustees Of The University Of Pennsylvania |
Wsx-1/p28 as a target for anti-inflammatory responses
|
RU2474589C9
(ru)
|
2006-11-02 |
2019-08-15 |
Дженентек, Инк. |
Гуманизированные антитела к фактору d и их применения
|
WO2008079280A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
NZ577933A
(en)
|
2007-01-22 |
2011-12-22 |
Genentech Inc |
Polyelectrolyte precipitation and purification of antibodies
|
EP1995309A1
(en)
*
|
2007-05-21 |
2008-11-26 |
Vivalis |
Recombinant protein production in avian EBx® cells
|
WO2009009523A2
(en)
|
2007-07-09 |
2009-01-15 |
Genentech, Inc. |
Prevention of disulfide bond reduction during recombinant production of polypeptides
|
JP5808037B2
(ja)
|
2007-10-19 |
2015-11-10 |
サーコード バイオサイエンス インク. |
糖尿病性網膜症の治療のための組成物及び方法
|
PT2215117E
(pt)
|
2007-10-30 |
2015-04-01 |
Genentech Inc |
Purificação de anticorpo por cromatografia de troca de catiões
|
US8080562B2
(en)
|
2008-04-15 |
2011-12-20 |
Sarcode Bioscience Inc. |
Crystalline pharmaceutical and methods of preparation and use thereof
|
US20090258070A1
(en)
*
|
2008-04-15 |
2009-10-15 |
John Burnier |
Topical LFA-1 antagonists for use in localized treatment of immune related disorders
|
CN102065893A
(zh)
*
|
2008-04-15 |
2011-05-18 |
萨可德公司 |
Lfa-1拮抗剂向胃肠系统的递送
|
JP2011518155A
(ja)
*
|
2008-04-15 |
2011-06-23 |
サーコード コーポレイション |
免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト
|
CR20170001A
(es)
|
2008-04-28 |
2017-08-10 |
Genentech Inc |
Anticuerpos anti factor d humanizados
|
US8999702B2
(en)
*
|
2008-06-11 |
2015-04-07 |
Emd Millipore Corporation |
Stirred tank bioreactor
|
US20100021460A1
(en)
*
|
2008-07-15 |
2010-01-28 |
Genentech, Inc. |
Methods of Treating Autoimmune Diseases Using CD4 Antibodies
|
SI2848625T1
(sl)
|
2008-08-14 |
2019-11-29 |
Genentech Inc |
Postopki za odstranjevanje kontaminanta z uporabo ionskoizmenjevalne membranske kromatografije z izpodrinjenjem nativnega proteina
|
MX2011002372A
(es)
|
2008-09-10 |
2011-04-04 |
Genentech Inc |
Composiciones y metodos para la prevencion de la degradacion oxidativa de proteinas.
|
WO2010062960A2
(en)
|
2008-11-26 |
2010-06-03 |
Cedars-Sinai Medical Center |
METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
|
WO2010074702A1
(en)
|
2008-12-16 |
2010-07-01 |
Millipore Corporation |
Purification of proteins
|
US20100190963A1
(en)
|
2008-12-16 |
2010-07-29 |
Millipore Corporation |
Stirred Tank Reactor And Method
|
US9580752B2
(en)
|
2008-12-24 |
2017-02-28 |
Cedars-Sinai Medical Center |
Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
|
SG173812A1
(en)
|
2009-02-27 |
2011-09-29 |
Genentech Inc |
Methods and compositions for protein labelling
|
AU2010282733B2
(en)
|
2009-08-11 |
2016-07-14 |
Genentech, Inc. |
Production of proteins in glutamine-free cell culture media
|
KR101764449B1
(ko)
|
2009-09-01 |
2017-08-02 |
제넨테크, 인크. |
변형된 단백질 a 용리를 통한 증진된 단백질 정제
|
US8378105B2
(en)
|
2009-10-21 |
2013-02-19 |
Sarcode Bioscience Inc. |
Crystalline pharmaceutical and methods of preparation and use thereof
|
US20120309056A1
(en)
|
2010-02-04 |
2012-12-06 |
Leon Arnaud |
Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
|
CA3027749A1
(en)
|
2010-03-22 |
2011-09-29 |
Junyan Ji |
Compositions and methods useful for stabilizing protein-containing formulations
|
SG183947A1
(en)
|
2010-03-31 |
2012-10-30 |
Boehringer Ingelheim Int |
Anti-cd40 antibodies
|
EP4450523A3
(en)
|
2010-04-02 |
2025-03-12 |
Amunix Pharmaceuticals, Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
JP2013525484A
(ja)
|
2010-05-03 |
2013-06-20 |
ジェネンテック, インコーポレイテッド |
タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法
|
KR101827855B1
(ko)
|
2010-05-17 |
2018-02-12 |
이엠디 밀리포어 코포레이션 |
생체분자 정제용 자극 반응성 중합체
|
BR112012030197A2
(pt)
|
2010-05-28 |
2015-09-29 |
Genentech Inc |
diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase.
|
AU2011270828B2
(en)
|
2010-06-24 |
2015-09-24 |
Genentech, Inc. |
Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
|
KR20130100125A
(ko)
|
2010-08-13 |
2013-09-09 |
제넨테크, 인크. |
질환의 치료를 위한, IL-1β 및 IL-18에 대한 항체
|
CA2807785A1
(en)
|
2010-08-23 |
2012-03-01 |
Pioneer Hi-Bred International, Inc. |
Novel defensin variants and methods of use
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
PE20141162A1
(es)
|
2010-11-04 |
2014-09-18 |
Boehringer Ingelheim Int |
Anticuerpos anti-il-23
|
EP3925625A1
(en)
|
2011-01-09 |
2021-12-22 |
ANP Technologies, Inc. |
Hydrophobic molecule-induced branched polymer aggregates and their use
|
WO2012095514A1
(en)
|
2011-01-14 |
2012-07-19 |
Vivalis |
Recombinant protein production system
|
CA2836857C
(en)
|
2011-05-21 |
2019-12-03 |
Macrogenics, Inc. |
Cd3-binding molecules capable of binding to human and non-human cd3
|
KR101902225B1
(ko)
|
2011-07-08 |
2018-09-28 |
이엠디 밀리포어 코포레이션 |
일회용 생명공학적 공정용의 개선된 심층 필터
|
US9023995B2
(en)
|
2011-11-16 |
2015-05-05 |
Boehringer Ingelheim International Gmbh |
Anti IL-36R antibodies
|
MX360453B
(es)
|
2011-12-22 |
2018-11-01 |
Genentech Inc |
Cromatografia de membrana de intercambio ionico.
|
MX365947B
(es)
|
2012-03-27 |
2019-06-19 |
Genentech Inc |
Operaciones de cosecha mejoradas para proteinas recombinadas.
|
PL3326649T3
(pl)
|
2012-05-03 |
2022-04-25 |
Boehringer Ingelheim International Gmbh |
Przeciwciała anty-il-23p19
|
TR201810930T4
(tr)
|
2012-05-18 |
2018-08-27 |
Genentech Inc |
Yüksek konsantrasyonlu monoklonal antikor formülasyonları.
|
CN110922393A
(zh)
|
2012-07-25 |
2020-03-27 |
诺华股份有限公司 |
Lfa-1抑制剂及其多晶型物
|
WO2014078522A1
(en)
|
2012-11-14 |
2014-05-22 |
Ohio State Innovation Foundation |
Materials and methods useful for treating glioblastoma
|
EP2934602B1
(en)
|
2012-12-19 |
2019-02-27 |
Genentech, Inc. |
Methods and compositions for radiohalogen protein labeling
|
AU2014215555B2
(en)
|
2013-02-05 |
2018-05-17 |
Anp Technologies, Inc. |
Nanoparticles containing a taxane and their use
|
JO3529B1
(ar)
|
2013-02-08 |
2020-07-05 |
Amgen Res Munich Gmbh |
مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
|
WO2014160883A1
(en)
|
2013-03-27 |
2014-10-02 |
Cedars-Sinai Medical Center |
Treating fibrosis and inflammation by inhibiting tl1a
|
EP3022295A4
(en)
|
2013-07-19 |
2017-03-01 |
Cedars-Sinai Medical Center |
Signature of tl1a (tnfsf15) signaling pathway
|
CR20160132A
(es)
|
2013-08-12 |
2016-08-25 |
Genentech Inc |
Composiciones y método para tratar condiciones asociadas con el complemento
|
EA033604B1
(ru)
|
2014-01-31 |
2019-11-08 |
Boehringer Ingelheim Int |
Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид
|
CA2944712A1
(en)
|
2014-05-01 |
2015-11-05 |
Genentech, Inc. |
Anti-factor d antibody variants and uses thereof
|
EP3777535A1
(en)
|
2014-07-09 |
2021-02-17 |
F. Hoffmann-La Roche AG |
Ph adjustment to improve thaw recovery of cell banks
|
JP2017524359A
(ja)
|
2014-07-24 |
2017-08-31 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Il−23a関連疾患の処置に有用なバイオマーカー
|
AU2016317028B2
(en)
|
2015-09-01 |
2021-09-09 |
Boehringer Ingelheim International Gmbh |
Use of anti-CD40 antibodies for treatment of lupus nephritis
|
HUE056769T2
(hu)
|
2015-09-04 |
2022-03-28 |
Primatope Therapeutics Inc |
Humanizált anti-CD40 antitestek és felhasználásuk
|
EP3368090A1
(en)
|
2015-10-30 |
2018-09-05 |
H. Hoffnabb-La Roche Ag |
Anti-factor d antibody variant conjugates and uses thereof
|
TW201730211A
(zh)
|
2015-10-30 |
2017-09-01 |
建南德克公司 |
抗因子d抗體及結合物
|
KR102464372B1
(ko)
|
2016-03-17 |
2022-11-04 |
세다르스-신나이 메디칼 센터 |
Rnaset2를 통한 염증성 장 질환의 진단 방법
|
AU2017242031B2
(en)
|
2016-03-29 |
2023-07-27 |
Geltor, Inc. |
Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
|
IL267439B2
(en)
|
2016-12-22 |
2023-02-01 |
Genentech Inc |
Methods and formulations for reducing reconstitution time of lyophilized polypeptides
|
US20180273627A1
(en)
|
2017-03-27 |
2018-09-27 |
Boehringer Ingelheim International Gmbh |
Anti il-36r antibodies combination therapy
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
CN112334195A
(zh)
|
2018-06-29 |
2021-02-05 |
勃林格殷格翰国际有限公司 |
用于治疗自身免疫性疾病的抗cd40抗体
|
HUE066560T2
(hu)
|
2018-07-03 |
2024-08-28 |
Bristol Myers Squibb Co |
Rekombináns proteinek elõállítási eljárásai
|
CN113166695A
(zh)
|
2018-10-10 |
2021-07-23 |
勃林格殷格翰国际公司 |
用于高密度生物反应器培养中的膜气体转移的方法
|
BR112021016198A2
(pt)
|
2019-03-08 |
2021-11-03 |
Boehringer Ingelheim Int |
Formulações de anticorpo anti-il-36r
|
BR112021019612A2
(pt)
|
2019-04-01 |
2021-11-30 |
Genentech Inc |
Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa
|
EP3953380A4
(en)
|
2019-04-12 |
2023-01-25 |
Geltor, Inc. |
RECOMBINATION ELASTIN AND ASSOCIATED PRODUCTION
|
KR20220039777A
(ko)
|
2019-08-01 |
2022-03-29 |
브리스톨-마이어스 스큅 컴퍼니 |
유가식 세포 배양에서 단백질 생산성을 개선시키는 방법
|
CN115867649A
(zh)
|
2020-03-24 |
2023-03-28 |
基因泰克公司 |
Tie2结合剂及其使用方法
|
WO2022061061A1
(en)
|
2020-09-21 |
2022-03-24 |
Boehringer Ingelheim International Gmbh |
Use of anti-cd40 antibodies for treatment of inflammatory conditions
|
KR20230073270A
(ko)
|
2020-09-22 |
2023-05-25 |
브리스톨-마이어스 스큅 컴퍼니 |
치료 단백질의 생산 방법
|
WO2022170008A2
(en)
|
2021-02-05 |
2022-08-11 |
Boehringer Ingelheim International Gmbh |
Anti-il1rap antibodies
|
WO2023015234A1
(en)
|
2021-08-05 |
2023-02-09 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
US20240390869A1
(en)
|
2021-09-21 |
2024-11-28 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|