GR3025752T3 - Assay methods and compositions for detecting serum proteases,particularly activated protein C. - Google Patents
Assay methods and compositions for detecting serum proteases,particularly activated protein C.Info
- Publication number
- GR3025752T3 GR3025752T3 GR970403402T GR970403402T GR3025752T3 GR 3025752 T3 GR3025752 T3 GR 3025752T3 GR 970403402 T GR970403402 T GR 970403402T GR 970403402 T GR970403402 T GR 970403402T GR 3025752 T3 GR3025752 T3 GR 3025752T3
- Authority
- GR
- Greece
- Prior art keywords
- compositions
- activated protein
- assay methods
- serum proteases
- proteases
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 5
- 239000004365 Protease Substances 0.000 title abstract 5
- 102000035195 Peptidases Human genes 0.000 title abstract 3
- 238000003556 assay Methods 0.000 title abstract 3
- 101800004937 Protein C Proteins 0.000 title abstract 2
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 title abstract 2
- 101800001700 Saposin-D Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960000856 protein c Drugs 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 239000013038 irreversible inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013037 reversible inhibitor Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/725,359 US5288612A (en) | 1991-07-03 | 1991-07-03 | Assay methods for detecting serum proteases, particularly activated protein C |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3025752T3 true GR3025752T3 (en) | 1998-03-31 |
Family
ID=24914223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970403402T GR3025752T3 (en) | 1991-07-03 | 1997-12-23 | Assay methods and compositions for detecting serum proteases,particularly activated protein C. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5288612A (fr) |
| EP (2) | EP0528525B1 (fr) |
| AT (1) | ATE160876T1 (fr) |
| CA (1) | CA2112702C (fr) |
| DE (1) | DE69223355T2 (fr) |
| DK (1) | DK0528525T3 (fr) |
| ES (1) | ES2109982T3 (fr) |
| GR (1) | GR3025752T3 (fr) |
| WO (1) | WO1993001309A1 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69132470D1 (de) * | 1990-08-06 | 2000-12-21 | Chiron Corp | Verfahren zum nachweis von cytokinkonvertasehemmern |
| US6099843A (en) * | 1991-02-12 | 2000-08-08 | Heska Corporation | Parasitic helminth PLA2 proteins |
| WO1993009804A1 (fr) * | 1991-11-18 | 1993-05-27 | The Scripps Research Institute | Polypeptides derives de la serine protease et anticorps anti-peptidiques, systemes et procedes therapeutiques empechant la coagulation du sang |
| US6121035A (en) * | 1991-12-13 | 2000-09-19 | Heska Corporation | Flea aminopeptidase proteins and uses thereof |
| US6150125A (en) | 1991-12-13 | 2000-11-21 | Heska Corporation | Flea protease proteins and uses thereof |
| US6210920B1 (en) | 1991-12-13 | 2001-04-03 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
| US6156556A (en) * | 1991-12-13 | 2000-12-05 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
| US5972645A (en) * | 1991-12-13 | 1999-10-26 | Heska Corporation | Flea serine protease nucleic acid molecules |
| US6146870A (en) * | 1991-12-13 | 2000-11-14 | Heska Corporation | Flea protease proteins |
| CA2088222A1 (fr) * | 1992-10-20 | 1994-04-21 | Nabil G. Seidah | Mise au point d'une methode de recherche et de moyens pour diagnostiquer et produire des convertases prohormones |
| US5416003A (en) * | 1993-04-14 | 1995-05-16 | Litmus Concepts, Inc. | Reporter enzyme release technology: methods of assaying for the presence of aspartic proteases and other hydrolytic enzyme activities |
| NL9301134A (nl) * | 1993-06-29 | 1995-01-16 | Inst Voor Agrotech Onderzoek | Werkwijze voor het detekteren en eventueel kwantificeren van aktiviteit van ten minste één protease-inhibitor in een te analyseren mengsel, alsmede toepassing van de werkwijze voor het bepalen van de (rest)aktiviteit van één (of meer) afzonderlijke (iso)type(s) protease-inhibitor(en) en toepassing van de werkwijze voor het bepalen van de totale (rest)aktiviteit van een mengsel eventueel na een verwerkingsproces zoals een proces ter verwijdering of inaktivatie van protease-inhibitor(en). |
| DK0633473T3 (da) * | 1993-06-30 | 1999-08-09 | Stiftung F R Diagnostische For | Måling af den aktiverede partielle thromboplastin-tid (APTT) i en reaktion i et enkelt trin |
| US6159746A (en) * | 1994-03-29 | 2000-12-12 | Gruppo Lepetit S.P.A. | Solid phase immunoassay to detect inhibitors of proteolytic enzymes |
| US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
| US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| US6214579B1 (en) | 1994-10-18 | 2001-04-10 | Heska Corporation | Flea leucine aminopeptidase nucleic acid molecules and uses thereof |
| US5776718A (en) * | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
| US6204010B1 (en) | 1995-06-07 | 2001-03-20 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
| US6139840A (en) * | 1995-10-18 | 2000-10-31 | Heska Corporation | Methods of eliciting an antibody response using flea protease proteins and homologs thereof |
| IL120704A0 (en) * | 1996-04-24 | 1998-04-05 | Heska Corp | Flea protease proteins nucleic acid molecules and uses thereof |
| DE19820328A1 (de) * | 1998-05-07 | 1999-11-11 | Roche Diagnostics Gmbh | Verfahren und Reagenz zum Nachweis apoptotischer Zellen bzw. einer bei Apoptose aktivierten Protease |
| US7037667B1 (en) | 1998-06-01 | 2006-05-02 | Agensys, Inc. | Tumor antigen useful in diagnosis and therapy of prostate and colon cancer |
| CA2329137C (fr) * | 1998-06-01 | 2011-09-20 | Urogenesys, Inc. | Nouvel antigene tumoral utile dans le diagnostic et la therapie propres au cancer de la prostate et du colon |
| FR2785053A1 (fr) * | 1998-10-21 | 2000-04-28 | Centre Nat Rech Scient | Procede de detection de l'activite enzymatique de l'enzyme poly(adp-ribose polymerase) et de detection de l'activite inhibitrice ou activatrice d'un inhibiteur ou d'un activateur de cette enzyme |
| DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
| DE602007006282D1 (de) * | 2006-02-24 | 2010-06-17 | Novo Nordisk Healthcare Ag | Verfahren zur entfernung eines nichtmetallischen proteinhemmers aus einer flüssigen pharmazeutischen zubereitung |
| EP3715356B1 (fr) | 2009-12-18 | 2023-10-11 | CSL Limited | Procédé de purification de polypeptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4112064A (en) * | 1977-02-22 | 1978-09-05 | Hoffmann-La Roche Inc. | Stabilized angiotensin I solutions |
| US4387166A (en) * | 1981-09-15 | 1983-06-07 | Anda Biologicals | Immunoassay wherein immune complex forms and ages for at least one hour |
| GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
| US5147638A (en) * | 1988-12-30 | 1992-09-15 | Oklahoma Medical Research Foundation | Inhibition of tumor growth by blockade of the protein C system |
-
1991
- 1991-07-03 US US07/725,359 patent/US5288612A/en not_active Expired - Lifetime
-
1992
- 1992-07-02 EP EP92306108A patent/EP0528525B1/fr not_active Expired - Lifetime
- 1992-07-02 DK DK92306108.9T patent/DK0528525T3/da active
- 1992-07-02 CA CA002112702A patent/CA2112702C/fr not_active Expired - Fee Related
- 1992-07-02 ES ES92306108T patent/ES2109982T3/es not_active Expired - Lifetime
- 1992-07-02 AT AT92306108T patent/ATE160876T1/de not_active IP Right Cessation
- 1992-07-02 DE DE69223355T patent/DE69223355T2/de not_active Expired - Fee Related
- 1992-07-02 EP EP19920915071 patent/EP0595865A4/en active Pending
- 1992-07-02 WO PCT/US1992/005590 patent/WO1993001309A1/fr not_active Application Discontinuation
-
1997
- 1997-12-23 GR GR970403402T patent/GR3025752T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5288612A (en) | 1994-02-22 |
| EP0595865A1 (fr) | 1994-05-11 |
| CA2112702A1 (fr) | 1993-01-21 |
| EP0528525A1 (fr) | 1993-02-24 |
| AU652474B2 (en) | 1994-08-25 |
| DE69223355T2 (de) | 1998-05-28 |
| EP0528525B1 (fr) | 1997-12-03 |
| WO1993001309A1 (fr) | 1993-01-21 |
| DK0528525T3 (da) | 1998-02-23 |
| CA2112702C (fr) | 2004-06-08 |
| EP0595865A4 (en) | 1994-06-22 |
| DE69223355D1 (de) | 1998-01-15 |
| ATE160876T1 (de) | 1997-12-15 |
| ES2109982T3 (es) | 1998-02-01 |
| AU2317492A (en) | 1993-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GR3025752T3 (en) | Assay methods and compositions for detecting serum proteases,particularly activated protein C. | |
| IL151570A0 (en) | Method for diagnosing immunologic food sensitivity | |
| CA2285919A1 (fr) | Tests et trousses de diagnostic pour clostridium difficile | |
| EP0805215A3 (fr) | Procédé et sondes diagnostiques | |
| DE69912899D1 (de) | Blutgerinnsel-Detektor | |
| CA2392711A1 (fr) | Procede pour mesurer l'activite des desacetylases et procede pour cribler les inhibiteurs ou promoteurs de ces enzymes | |
| DK0941468T3 (da) | Et-trins-hybridimmunochromatografisk udstyr og fremgangsmåde til anvendelse heraf | |
| ATE403153T1 (de) | Test zum direkten nachweisen einer rs virus bezogenen biologischen zelle in einer körperflüssigkeitsprobe | |
| WO2002065128A3 (fr) | Test urinaire permettant de determiner la reserve ovarienne | |
| CA2162531A1 (fr) | Methode pour la detection specifique d'un facteur de coagulation v qui possede une plus grande stabilite vis-a-vis de la proteine c activee | |
| WO1991019195A3 (fr) | Methode de detection et/ou de dosage des hormones et anticorps utilisables dans ladite methode de detection | |
| DE60225802D1 (de) | Verfahren und gerät zum nachweis des gesamten proteingehaltes bei niedrigen ph-werten | |
| WO2003054225A3 (fr) | Procede de determination d'analytes du type acide nucleique | |
| AU1370592A (en) | Immunoassay for detection of mutant p53 polypeptide in biological fluids | |
| AU2147295A (en) | Rapid assays for the detection of glutathione s-transferases | |
| EP0346119A3 (fr) | Essai anti-FC pour détecter des anticorps | |
| CA2242197A1 (fr) | Methode de detection des proteines totales | |
| AU2003260530A1 (en) | Method for detecting a risk of acid related disease in an individual | |
| WO2001083816A3 (fr) | Procedes de detection de tumeurs | |
| WO2001090408A3 (fr) | Detection et caracterisation de l'activite de proteines impliquees dans la reparation de lesions de l'adn | |
| CA2213083A1 (fr) | Detection de la production d'anticorps | |
| AU1690899A (en) | Method for testing crohn's disease and testing kit therefor | |
| WO1999027366A3 (fr) | Detection de l'antigene prostate-specifique | |
| AU653933B2 (en) | A method for the detection of plasminogen activators, their inhibitors or stimulators | |
| WO2002010437A3 (fr) | Substrats synthetiques et recombines pour la detection de la protease de clivage du facteur de von willebrand |