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GR3002714T3 - N-phenyl butenamides with pharmaceutical properties - Google Patents

N-phenyl butenamides with pharmaceutical properties

Info

Publication number
GR3002714T3
GR3002714T3 GR91401318T GR910401318T GR3002714T3 GR 3002714 T3 GR3002714 T3 GR 3002714T3 GR 91401318 T GR91401318 T GR 91401318T GR 910401318 T GR910401318 T GR 910401318T GR 3002714 T3 GR3002714 T3 GR 3002714T3
Authority
GR
Greece
Prior art keywords
butenamides
phenyl
pharmaceutical properties
pharmaceutical
properties
Prior art date
Application number
GR91401318T
Other languages
Greek (el)
Inventor
Peter Thaddeus Gallagher
Terence Alan Hicks
Graham Walter Mullier
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of GR3002714T3 publication Critical patent/GR3002714T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
GR91401318T 1986-08-08 1991-09-12 N-phenyl butenamides with pharmaceutical properties GR3002714T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619432A GB8619432D0 (en) 1986-08-08 1986-08-08 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
GR3002714T3 true GR3002714T3 (en) 1993-01-25

Family

ID=10602473

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91401318T GR3002714T3 (en) 1986-08-08 1991-09-12 N-phenyl butenamides with pharmaceutical properties

Country Status (23)

Country Link
US (1) US4892963A (en)
EP (1) EP0257882B1 (en)
JP (1) JPS63239259A (en)
KR (2) KR880002823A (en)
CN (1) CN1015256B (en)
AR (2) AR244660A1 (en)
AT (1) ATE65494T1 (en)
AU (1) AU604737B2 (en)
CA (1) CA1317964C (en)
DE (1) DE3771611D1 (en)
DK (1) DK169404B1 (en)
EG (1) EG18269A (en)
ES (1) ES2031510T3 (en)
GB (1) GB8619432D0 (en)
GR (1) GR3002714T3 (en)
HU (1) HU197559B (en)
IL (1) IL83432A (en)
MX (1) MX174371B (en)
NZ (1) NZ221352A (en)
PH (1) PH22821A (en)
PT (1) PT85476B (en)
RU (1) RU1771472C (en)
ZA (1) ZA875813B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DE3534440A1 (en) * 1985-09-27 1987-04-02 Hoechst Ag DRUGS AGAINST CHRONIC GRAFT VERSUS HOST DISEASES AND AUTO AUTO DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATODES
US4975462A (en) * 1988-07-29 1990-12-04 Bristol-Myers Company Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
DD297328A5 (en) * 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-METHYL-ISOXALOL-4-CARBONSAEANEANILIDE AND 2 HYDROXYETHYLIDENE CYANO ACID ACIDANILIDES FOR THE TREATMENT OF EYE DISEASES
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
JPH04211048A (en) * 1990-03-05 1992-08-03 Mitsubishi Kasei Corp Thiocarbamoylacetonitrile derivative
RU2084223C1 (en) * 1990-05-18 1997-07-20 Хехст АГ Use of isoxazole-4-carboxylic acid amides and hydroxyalkylidenecyanoacetic acid amides
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf History of 3-cycloalkyl-prop-2-anamide
DE59203828D1 (en) * 1991-10-23 1995-11-02 Hoechst Ag N-phenyl-2-cyano-3-hydroxycrotoxamide derivatives and their use as medicaments with immunomodulatory properties.
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
TW314467B (en) * 1993-03-31 1997-09-01 Hoechst Ag
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
GB9320299D0 (en) * 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
US5814649A (en) * 1994-10-17 1998-09-29 Hoechst Pharmaceuticals & Chemicals K.K. Preventive and remedy for type 1 allergic diseases
DE19702988A1 (en) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazole and crotonic acid amide derivatives and their use as pharmaceuticals and diagnostics
YU45102A (en) * 1999-12-16 2006-01-16 Teva Pharmaceutical Industries Ltd. Novel processes for making-and a new crystalline form of-leflunomide
JP2004500380A (en) 2000-02-15 2004-01-08 テバ　ファーマシューティカル　インダストリーズ　リミティド Method for synthesizing leflunomide
DE10311763A1 (en) * 2003-03-18 2004-10-07 Aventis Pharma Deutschland Gmbh Process for the preparation of 2-cyano-3-hydroxy-N- (phenyl) but-2-enamides
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
AU2014352920A1 (en) 2013-11-22 2016-06-23 Genzyme Corporation Novel methods for treating neurodegenerative diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (en) * 1975-06-05 Hoechst Ag PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTIFLOGISTICAL AND / OR ANALGETICAL ACTION AND PROCEDURE FOR THE PREPARATION OF A 2-HYDROXYETHYLIDE ENCYANAACETIC ANILIDE SUITABLE FOR USE IN THIS PROCESS.
DK545976A (en) * 1975-12-11 1977-06-12 Hoechst Ag CYANACIC ACID ANILIDE DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND MEASURES CONTAINING THESE COMPOUNDS
DE2654797A1 (en) * 1976-12-03 1978-06-08 Hoechst Ag PROCESS FOR THE PREPARATION OF ISOXAZOLE DERIVATIVES
DE2655009A1 (en) * 1976-12-04 1978-06-15 Hoechst Ag ISOXAZOLE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEANS CONTAINING THESE COMPOUNDS
PT71367A (en) * 1979-06-11 1980-07-01 Ciba Geigy Ag Process for preparing alphacarbamoyl-pyrrolpropionitriles

Also Published As

Publication number Publication date
MX174371B (en) 1994-05-11
AR244660A1 (en) 1993-11-30
HUT44523A (en) 1988-03-28
ZA875813B (en) 1989-04-26
DK413987D0 (en) 1987-08-07
PH22821A (en) 1989-01-19
JPS63239259A (en) 1988-10-05
IL83432A (en) 1992-06-21
ATE65494T1 (en) 1991-08-15
NZ221352A (en) 1989-10-27
PT85476B (en) 1990-06-29
PT85476A (en) 1987-09-01
EP0257882B1 (en) 1991-07-24
KR880002823A (en) 1988-05-11
HU197559B (en) 1989-04-28
CA1317964C (en) 1993-05-18
US4892963A (en) 1990-01-09
EP0257882A1 (en) 1988-03-02
AU7668187A (en) 1988-02-11
CN87105516A (en) 1988-02-24
DK169404B1 (en) 1994-10-24
EG18269A (en) 1992-12-30
RU1771472C (en) 1992-10-23
AU604737B2 (en) 1991-01-03
CN1015256B (en) 1992-01-01
MX7668A (en) 1993-08-01
DK413987A (en) 1988-02-09
ES2031510T3 (en) 1992-12-16
GB8619432D0 (en) 1986-09-17
IL83432A0 (en) 1988-01-31
DE3771611D1 (en) 1991-08-29
AR247876A1 (en) 1995-04-28
KR880002815A (en) 1988-05-11

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