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GR1006917B - Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases - Google Patents

Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases

Info

Publication number
GR1006917B
GR1006917B GR20070100650A GR20070100650A GR1006917B GR 1006917 B GR1006917 B GR 1006917B GR 20070100650 A GR20070100650 A GR 20070100650A GR 20070100650 A GR20070100650 A GR 20070100650A GR 1006917 B GR1006917 B GR 1006917B
Authority
GR
Greece
Prior art keywords
angiotensin
receptor antagonists
cardiovascular diseases
hypertension
histamin
Prior art date
Application number
GR20070100650A
Other languages
Greek (el)
Other versions
GR20070100650A (en
Inventor
Μιχαηλ Μαραγκουδακις
Ιωαννης Ματσουκας
Δημητριος Βλαχακος
Χαραλαμπος Γαβρας
Original Assignee
Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε., filed Critical Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε.,
Priority to GR20070100650A priority Critical patent/GR1006917B/en
Priority to US12/671,242 priority patent/US20100216854A1/en
Priority to PCT/IB2008/002796 priority patent/WO2009016514A2/en
Priority to EP08826802A priority patent/EP2188279A2/en
Publication of GR20070100650A publication Critical patent/GR20070100650A/en
Publication of GR1006917B publication Critical patent/GR1006917B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides novel 1, 5 and 1, 3, 5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.
GR20070100650A 2007-08-01 2007-10-24 Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases GR1006917B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GR20070100650A GR1006917B (en) 2007-10-24 2007-10-24 Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases
US12/671,242 US20100216854A1 (en) 2007-08-01 2008-07-25 1,3 and 1,3,5 substituted imidazoles as antihypertensives
PCT/IB2008/002796 WO2009016514A2 (en) 2007-08-01 2008-07-25 1, 3 and 1, 3, 5 substituted imidazoles as antihypertensiva
EP08826802A EP2188279A2 (en) 2007-08-01 2008-07-25 1,3 and 1,3,5 substituted imidazoles as antihypertensiva

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20070100650A GR1006917B (en) 2007-10-24 2007-10-24 Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases

Publications (2)

Publication Number Publication Date
GR20070100650A GR20070100650A (en) 2009-05-15
GR1006917B true GR1006917B (en) 2010-07-30

Family

ID=40248058

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20070100650A GR1006917B (en) 2007-08-01 2007-10-24 Angiotensin ii receptor antagonists based on histamin with sympathetic suppressant properties ans synthetic methods in the treatment of hypertension and cardiovascular diseases

Country Status (1)

Country Link
GR (1) GR1006917B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2028925A1 (en) * 1989-11-06 1991-05-07 Gerald R. Girard Substituted n-(imidazolyl)alkyl alanine derivatives
FR2689508B1 (en) * 1992-04-01 1994-06-17 Fournier Ind & Sante IMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION.

Also Published As

Publication number Publication date
GR20070100650A (en) 2009-05-15

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Legal Events

Date Code Title Description
PG Patent granted
ML Lapse due to non-payment of fees

Effective date: 20110503