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GR1003885B - Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer - Google Patents

Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Info

Publication number
GR1003885B
GR1003885B GR20000100283A GR2000100283A GR1003885B GR 1003885 B GR1003885 B GR 1003885B GR 20000100283 A GR20000100283 A GR 20000100283A GR 2000100283 A GR2000100283 A GR 2000100283A GR 1003885 B GR1003885 B GR 1003885B
Authority
GR
Greece
Prior art keywords
treatment
thrombosis
cancer
thrombin receptor
s42fllr46
Prior art date
Application number
GR20000100283A
Other languages
Greek (el)
Other versions
GR20000100283A (en
Inventor
Κωνσταντινος Αλεξοπουλος
Δημητριος Βλαχακος
Μιχαηλ Μαραγκουδακης
Ιωαννης Ματσουκας
Original Assignee
Κωνσταντινος Αλεξοπουλος
Δημητριος Βλαχακος
Μιχαηλ Μαραγκουδακης
Ιωαννης Ματσουκας
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Κωνσταντινος Αλεξοπουλος, Δημητριος Βλαχακος, Μιχαηλ Μαραγκουδακης, Ιωαννης Ματσουκας filed Critical Κωνσταντινος Αλεξοπουλος
Priority to GR20000100283A priority Critical patent/GR20000100283A/en
Publication of GR1003885B publication Critical patent/GR1003885B/en
Publication of GR20000100283A publication Critical patent/GR20000100283A/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

he invention relates to novel non peptide compounds (mimetics) based on a thrombin receptor sequence and novel methods for the synthesis of these compounds. These compounds act as agonists or antagonists in a variety of cells including endothelial cells, blood platelets, vascular smooth muscle cells and tumor cells. They are useful in the treatment of thrombosis and cardiovascular diseases and modulation of angiogenesis for cancer treatment or wound healing.
GR20000100283A 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer GR20000100283A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Publications (2)

Publication Number Publication Date
GR1003885B true GR1003885B (en) 2002-05-09
GR20000100283A GR20000100283A (en) 2002-05-24

Family

ID=10944358

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000100283A GR20000100283A (en) 2000-08-17 2000-08-17 Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer

Country Status (1)

Country Link
GR (1) GR20000100283A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
WO2009146540A1 (en) * 2008-06-02 2009-12-10 Neuromed Pharmaceuticals Ltd N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
US11427540B2 (en) 2019-07-11 2022-08-30 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
WO2006023844A3 (en) * 2004-08-20 2007-04-19 Entremed Inc Compositions and methods comprising proteinase activated receptor antagonists
WO2009146540A1 (en) * 2008-06-02 2009-12-10 Neuromed Pharmaceuticals Ltd N-piperidinyl acetamide derivatives as calcium channel blockers
US8569344B2 (en) 2008-06-02 2013-10-29 Zalicus Pharmaceuticals Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US9096522B2 (en) 2008-06-02 2015-08-04 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
US11427540B2 (en) 2019-07-11 2022-08-30 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof
US11649207B2 (en) 2019-07-11 2023-05-16 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof

Also Published As

Publication number Publication date
GR20000100283A (en) 2002-05-24

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