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GR1002144B - Stale bioactive somatotropins - Google Patents

Stale bioactive somatotropins

Info

Publication number
GR1002144B
GR1002144B GR890100562A GR890100562A GR1002144B GR 1002144 B GR1002144 B GR 1002144B GR 890100562 A GR890100562 A GR 890100562A GR 890100562 A GR890100562 A GR 890100562A GR 1002144 B GR1002144 B GR 1002144B
Authority
GR
Greece
Prior art keywords
stale
somatotropins
bioactive
bioactive somatotropins
stale bioactive
Prior art date
Application number
GR890100562A
Other languages
English (en)
Other versions
GR890100562A (el
Inventor
James E Seely
Zafar I Randawa
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Publication of GR890100562A publication Critical patent/GR890100562A/el
Publication of GR1002144B publication Critical patent/GR1002144B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
GR890100562A 1988-09-12 1989-09-08 Stale bioactive somatotropins GR1002144B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/242,542 US5079230A (en) 1988-09-12 1988-09-12 Stable bioactive somatotropins

Publications (2)

Publication Number Publication Date
GR890100562A GR890100562A (el) 1990-10-31
GR1002144B true GR1002144B (en) 1996-02-16

Family

ID=22915193

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100562A GR1002144B (en) 1988-09-12 1989-09-08 Stale bioactive somatotropins

Country Status (16)

Country Link
US (1) US5079230A (el)
EP (1) EP0433395A1 (el)
JP (1) JPH04500519A (el)
CN (1) CN1037845C (el)
AU (1) AU4330889A (el)
CA (1) CA1339759C (el)
DD (1) DD289544A5 (el)
ES (1) ES2018397A6 (el)
GR (1) GR1002144B (el)
HU (2) HU206375B (el)
NZ (1) NZ230610A (el)
PL (1) PL162822B1 (el)
RU (1) RU2073686C1 (el)
UA (1) UA26853C2 (el)
WO (1) WO1990002758A1 (el)
ZA (1) ZA896914B (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2154627T3 (es) * 1988-08-24 2001-04-16 American Cyanamid Co Estabilizacion de somatotropinas mediante la modificacion de restos de cisteina utilizando mutagenesis de localizacion dirigida o derivatizacion quimica.
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5169834A (en) * 1990-11-30 1992-12-08 American Cyanamid Company Compositions and method for reducing vial breakage during lyophilization
US5567620A (en) * 1993-01-26 1996-10-22 Eli Lilly And Company Non-denaturing potency assay for somatotropin
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
DE4303744A1 (de) * 1993-02-09 1994-08-11 Univ Autonoma De Nuevo Leon Mo Hundewachstumshormon
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
AU7493198A (en) * 1997-05-15 1998-12-08 Geoffrey J Schmidt Method of reducing immunological tolerance to malignancy
CN1197968C (zh) * 1997-06-25 2005-04-20 应用研究系统Ars股份公司 二硫键交联的糖蛋白激素类似物及其制备和应用
EP1315511A4 (en) * 2000-09-08 2005-10-19 Gryphon Therapeutics Inc SYNTHESIS PROTEINS STIMULATING ERYTHROPOYSIS
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP2525834B1 (en) * 2010-01-22 2019-07-17 Novo Nordisk Health Care AG Growth hormones with prolonged in-vivo efficacy
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients
JP6464145B2 (ja) 2013-04-05 2019-02-06 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 成長ホルモン化合物製剤
CN108828237B (zh) * 2018-08-24 2021-04-02 浙江理工大学 一种分析羊毛角蛋白中氨基酸键合折叠分布的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853832A (en) * 1971-04-27 1974-12-10 Harmone Res Foundation Synthetic human pituitary growth hormone and method of producing it
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
JPS5630925A (en) * 1979-08-21 1981-03-28 Sumitomo Chem Co Ltd Purification of human growth hormone
EP0103395A3 (en) * 1982-08-17 1985-05-22 Biogen N.V. Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
CA1341012C (en) * 1982-09-27 2000-06-06 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
WO1987000204A2 (en) * 1985-06-26 1987-01-15 The Upjohn Company Purification of somatotropin from transformed microorganisms
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4816568A (en) * 1986-05-16 1989-03-28 International Minerals & Chemical Corp. Stabilization of growth hormones
ES2154627T3 (es) * 1988-08-24 2001-04-16 American Cyanamid Co Estabilizacion de somatotropinas mediante la modificacion de restos de cisteina utilizando mutagenesis de localizacion dirigida o derivatizacion quimica.

Also Published As

Publication number Publication date
ES2018397A6 (es) 1991-04-01
JPH04500519A (ja) 1992-01-30
UA26853C2 (uk) 1999-12-29
CN1037845C (zh) 1998-03-25
NZ230610A (en) 1991-12-23
CA1339759C (en) 1998-03-17
DD289544A5 (de) 1991-05-02
HU206375B (en) 1992-10-28
PL162822B1 (pl) 1994-01-31
CN1041160A (zh) 1990-04-11
ZA896914B (en) 1990-10-31
RU2073686C1 (ru) 1997-02-20
AU4330889A (en) 1990-04-02
EP0433395A1 (en) 1991-06-26
HUT56856A (en) 1991-10-28
US5079230A (en) 1992-01-07
HU910787D0 (en) 1991-09-30
WO1990002758A1 (en) 1990-03-22
GR890100562A (el) 1990-10-31

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