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GR1001034B - Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος. - Google Patents

Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.

Info

Publication number
GR1001034B
GR1001034B GR900100551A GR900100551A GR1001034B GR 1001034 B GR1001034 B GR 1001034B GR 900100551 A GR900100551 A GR 900100551A GR 900100551 A GR900100551 A GR 900100551A GR 1001034 B GR1001034 B GR 1001034B
Authority
GR
Greece
Prior art keywords
multiplicator
control
peripheral blood
regional blood
population
Prior art date
Application number
GR900100551A
Other languages
English (en)
Other versions
GR900100551A (el
Inventor
Teruaki Sekine
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23515405&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR1001034(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of GR900100551A publication Critical patent/GR900100551A/el
Publication of GR1001034B publication Critical patent/GR1001034B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

H εφεύρεση αυτή αναφέρεται σε μια επιλεκτική μέθοδο πολλαπλασιασμού τουλάχιστον ενός από ορισμένους κυτταρικούς υποπληθυσμούς λεμφοκυττάρων, ιδιαίτερα CD4+, CD8+ και Φυσικού Δολοφόνου (ΝΚ), εντός ενός πληθυσμού έναρξης λεμφοκυττάρων περιφερειακού αίματος (PBL). Μια σχετικά μικρή ποσότητα ενός αρχικού (ενάρξεως) κυτταρικού πληθυσμού λεμφοκυττάρων περιφερειακού αίματος καλλιεργείται σε μια διαδικασία πολλών σταδίων αρχίζοντας με ένα αντισώμα αντιCD3 ακινητοποιημένο σε ένα υπόστρωμα καλλιέργειας. ω
GR900100551A 1989-07-21 1990-07-18 Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος. GR1001034B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38394289A 1989-07-21 1989-07-21

Publications (2)

Publication Number Publication Date
GR900100551A GR900100551A (el) 1991-12-10
GR1001034B true GR1001034B (el) 1993-03-31

Family

ID=23515405

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100551A GR1001034B (el) 1989-07-21 1990-07-18 Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.

Country Status (7)

Country Link
EP (1) EP0409655A3 (el)
JP (1) JP3056230B2 (el)
AU (1) AU633940B2 (el)
CA (1) CA2021500C (el)
GR (1) GR1001034B (el)
IE (1) IE902662A1 (el)
ZA (1) ZA905735B (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2981486B2 (ja) * 1988-06-14 1999-11-22 メディカル・バイオロジー・インスティチュート 哺乳動物の免疫系研究方法
EP0578740A4 (en) * 1991-04-05 1995-12-20 Univ Minnesota Method of enhancing the immunotherapeutic activity of immune cells by depletion/positive selection of cell subsets
US5725855A (en) * 1991-04-05 1998-03-10 The United States Of America As Represented By The Department Of Health And Human Services Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations
IE922233A1 (en) * 1991-07-10 1993-01-13 Augusto C Ochoa Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity
WO1995032729A1 (en) * 1994-05-31 1995-12-07 Augusto Carlos Ochoa Short-term anti-cd3 stimulation of lymphocytes to increase their in vivo activity
US6511848B2 (en) 1996-04-17 2003-01-28 Winfried Albert Process for producing and multiplying lymphocytes
ES2227688T3 (es) * 1996-04-17 2005-04-01 Albert, Winfried, Dr. Procedimiento para la produccion y multiplicacion de linfocitos.
DE69738997D1 (de) * 1996-07-15 2008-10-30 Lymphotec Inc Mittel zur heilung bzw. vorbeugung viraler infektionen, verfahren zu deren herstellung sowie verfahren zur vorbeugung bzw. heilung viraler infektionen
SE511143C2 (sv) 1997-12-30 1999-08-09 Sca Hygiene Paper Ab Metod att framställa ett papper uppvisande en tredimensionellt mönster
JP2001354575A (ja) 2000-06-09 2001-12-25 Human Tekku:Kk 癌の再発予防法および癌の再発予防用活性化リンパ球を含む製剤、ならびにそれらの細胞の凍結および加工委・受託システム
JP4917201B2 (ja) * 2000-12-04 2012-04-18 株式会社リンフォテック 臍帯血移植後の腫瘍および各種感染症の予防・治療用製剤、臍帯血移植後の移植臍帯血幹細胞の生着促進用製剤、臍帯血移植後の腫瘍および各種感染症の予防・治療用製剤ならびに臍帯血移植後の移植臍帯血幹細胞の生着促進用製剤の製造方法。
CA2439811A1 (en) * 2001-03-05 2002-09-12 Lymphotec Inc. Method of treating tumor and consignment system of proliferating and processing activated lymphocytes to be used in parallel to pdt
DE10120505A1 (de) * 2001-04-26 2002-11-07 Rudolf Wank Verwendung von stimulierten mononukleären Zellen des peripheren Blutes zur Behandlung von Krebserkrankungen
MXPA04009287A (es) 2002-03-25 2005-01-25 Takara Bio Inc Proceso para producir linfocito citotoxico.
JP4562353B2 (ja) * 2002-04-08 2010-10-13 株式会社リンフォテック Ｈｌａ一致他人由来活性化リンパ球を含有してなる腫瘍・感染症および自己免疫疾患の予防・治療用製剤
US20070025961A1 (en) 2003-06-03 2007-02-01 Kenzo Bamba Composition for stabilizing survival of transplanted hematopoietic stem cell, kit for obtaining the composition, method of stabilizing survival of transplanted hematopoietic stem cell, human monoclonal antibody or human polyclonal antibody and method of producing the same, gene encoding human monoclonal antibody and transf
CN1839202B (zh) 2003-08-22 2012-07-18 宝生物工程株式会社 细胞毒性淋巴细胞的制备方法
JP2006143709A (ja) * 2004-10-20 2006-06-08 Lymphotec:Kk 薬剤耐性原生生物感染症の治療もしくは予防用製剤、該製剤の調製用キットおよび調製方法、薬剤耐性原生生物感染症の治療方法
WO2007020880A1 (ja) * 2005-08-17 2007-02-22 Takara Bio Inc. リンパ球の製造方法
EP2392673A1 (en) * 2006-06-02 2011-12-07 GlaxoSmithKline Biologicals S.A. Method for identifying whether a patient will be responder or not to immunotherapy based on the differential expression of the FOXP3 gene
KR101133185B1 (ko) * 2008-07-29 2012-04-06 서울대학교병원 자연살해세포의 증식방법
WO2018124119A1 (ja) * 2016-12-27 2018-07-05 住友化学株式会社 染色体の異常の検出方法および誘発性を評価する方法
JP7268039B2 (ja) 2018-02-01 2023-05-02 エヌケーマックス カンパニー リミテッド がん治療のためのナチュラルキラー細胞および組成物の製造方法
WO2021085504A1 (ja) 2019-11-01 2021-05-06 京都府公立大学法人 Ｂ細胞抗体受容体、及びその利用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE82588T1 (de) * 1986-04-28 1992-12-15 Endotronics Inc Zuchtverfahren fuer leukocyten.
WO1988000970A2 (en) * 1986-08-08 1988-02-11 Regents Of The University Of Minnesota Method of culturing leukocytes
DE3634017A1 (de) * 1986-10-06 1988-04-14 Max Planck Gesellschaft Verfahren zur aktivierung und vermehrung von t-zellen, insbesondere von deren subpopulationen
AU4485089A (en) * 1988-10-21 1990-05-14 Brigham And Women's Hospital Activation and growth of human tumor-infiltrating lymphocytes using antibodies to cd3 or tcr

Also Published As

Publication number Publication date
GR900100551A (el) 1991-12-10
AU633940B2 (en) 1993-02-11
CA2021500A1 (en) 1991-01-22
IE902662A1 (en) 1991-02-27
JPH0380076A (ja) 1991-04-04
ZA905735B (en) 1992-03-25
CA2021500C (en) 1995-06-13
JP3056230B2 (ja) 2000-06-26
AU5918290A (en) 1991-01-24
EP0409655A2 (en) 1991-01-23
EP0409655A3 (en) 1992-04-15

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