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GR1000941B - Method for preparing 1,2,4-benzotriazine oxides - Google Patents

Method for preparing 1,2,4-benzotriazine oxides

Info

Publication number
GR1000941B
GR1000941B GR890100167A GR890100167A GR1000941B GR 1000941 B GR1000941 B GR 1000941B GR 890100167 A GR890100167 A GR 890100167A GR 890100167 A GR890100167 A GR 890100167A GR 1000941 B GR1000941 B GR 1000941B
Authority
GR
Greece
Prior art keywords
preparing
benzotriazine oxides
cytotoxic agents
benzotriazine
oxides
Prior art date
Application number
GR890100167A
Other languages
Greek (el)
Other versions
GR890100167A (en
Inventor
J Martin Brown
W Edward Grange
W William Lee
P Abelardo Martinez
Michael Tracy
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of GR890100167A publication Critical patent/GR890100167A/en
Publication of GR1000941B publication Critical patent/GR1000941B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Κοινολογείται μια μέθοδος χρησιμοποίησης οξειδίων 1,2,4- βενζοτριαζίνης ως ραδιοευαισθητοποιητών και επιλεκτικών κυτταροτοξικών παραγόντων. Οι ενώσεις δείχνεται ότι ευαισθητοποιούν ειδικά τα υποξικά κύτταρα όγκων και επιπλέον κοινολογούνται ως χρήσιμες ως ειδικοί κυτταροτοξικοί παράγοντες για τα κύτταρα αυτά. ωA method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically sensitize hypoxic tumor cells and are further disclosed to be useful as specific cytotoxic agents for these cells. oh

GR890100167A 1989-03-17 1989-03-17 Method for preparing 1,2,4-benzotriazine oxides GR1000941B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR89100167 1989-03-17

Publications (2)

Publication Number Publication Date
GR890100167A GR890100167A (en) 1990-07-31
GR1000941B true GR1000941B (en) 1993-03-16

Family

ID=10939355

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100167A GR1000941B (en) 1989-03-17 1989-03-17 Method for preparing 1,2,4-benzotriazine oxides

Country Status (1)

Country Link
GR (1) GR1000941B (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (en) * 1963-10-22 1970-03-15 Siegfried Ag Process for the preparation of therapeutically active 1,2-dihydro-1,2,4-benzotriazines
DE1809390A1 (en) * 1968-11-16 1970-06-11 Bayer Ag Phosphorus, phosphonic or thionophosphorus (- phosphonic) acid esters and process for their production
IL44058A (en) * 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
DE2538179C2 (en) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-alkoxy-benzo-1,2,4-triazines, process for their preparation and their use as fungicides
DE2740887A1 (en) * 1977-09-10 1979-03-22 Bayer Ag AGENTS FOR CONTROLLING PLANT BACTERIOS
JP2668232B2 (en) * 1986-09-25 1997-10-27 エス・アール・アイ・インターナシヨナル 1,2,4-benzotriazine oxide as radiosensitizer and selective cytotoxic agent

Also Published As

Publication number Publication date
GR890100167A (en) 1990-07-31

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