GB996704A - New steroidthiazole compounds and process for the production thereof - Google Patents
New steroidthiazole compounds and process for the production thereofInfo
- Publication number
- GB996704A GB996704A GB3565261A GB3565261A GB996704A GB 996704 A GB996704 A GB 996704A GB 3565261 A GB3565261 A GB 3565261A GB 3565261 A GB3565261 A GB 3565261A GB 996704 A GB996704 A GB 996704A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- steroid
- above significance
- oxygen atom
- thiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises steroid-thiazoles of the general formula <FORM:0996704/C2/1> wherein R1 represents two hydrogen atoms or an oxygen atom, R2 represents a hydrogen atom or a hydroxy radical, R3 represents a hydrogen atom or an alkyl radical, and R4 represents an alkyl, cycloalkyl or phenyl radical or a phenyl radical substituted by one or more alkoxy, halogen or alkyl substituents, and the preparation thereof by reacting steroid compounds of the general formula <FORM:0996704/C2/2> wherein X represents a halogen or -OSO2CH3 and R1 and R2 have the above significance, with a substituted thiourea of the general formula <FORM:0996704/C2/3> wherein R3 and R4 have the above significance. The invention also includes a process for reducing steroid-thiazoles of the first general formula above wherein R1 represents two hydrogen atoms with an alkali metal complex hydride to form steroid-thiazoles of the general formula <FORM:0996704/C2/4> wherein R3 and R4 have the above significance' and a process for the preparation of steroids of the general formula <FORM:0996704/C2/5> wherein Z represents an oxygen atom or <FORM:0996704/C2/6> , R4 has the above significance and R5 represents a hydrogen atom or -COCH2CH2COOH, but when Z is an oxygen atom R5 always represents -COCH2CH2COOH, by reacting steroids of the general formula <FORM:0996704/C2/7> wherein Y represents an oxygen atom or <FORM:0996704/C2/8> and R4 has the above significance.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4032460 | 1960-10-06 | ||
| JP4165760 | 1960-10-19 | ||
| JP1462061 | 1961-04-24 | ||
| JP2536761 | 1961-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB996704A true GB996704A (en) | 1965-06-30 |
Family
ID=27456244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3565261A Expired GB996704A (en) | 1960-10-06 | 1961-10-03 | New steroidthiazole compounds and process for the production thereof |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR1450M (en) |
| GB (1) | GB996704A (en) |
-
1961
- 1961-10-03 GB GB3565261A patent/GB996704A/en not_active Expired
- 1961-10-04 FR FR875006A patent/FR1450M/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1450M (en) | 1962-08-20 |
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