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GB973912A - Derivatives of 8-azaoestrane and 8-aza-d-homooestrane - Google Patents

Derivatives of 8-azaoestrane and 8-aza-d-homooestrane

Info

Publication number
GB973912A
GB973912A GB2141462A GB2141462A GB973912A GB 973912 A GB973912 A GB 973912A GB 2141462 A GB2141462 A GB 2141462A GB 2141462 A GB2141462 A GB 2141462A GB 973912 A GB973912 A GB 973912A
Authority
GB
United Kingdom
Prior art keywords
stands
hydrogen
alkyl
stand
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2141462A
Inventor
Richard Clarkson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE633213D priority Critical patent/BE633213A/xx
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2141462A priority patent/GB973912A/en
Publication of GB973912A publication Critical patent/GB973912A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises isoquinoline derivatives of general formula <F\1> wherein R1 and R2, which may be the same or different, stand for allyl radicals, R3 stands for hydrogen or an alkoxy radical, R4 stands for hydrogen or an alkyl or alkoxy radical, R5 and R6, which may be the same or different, stand for hydrogen or alkyl radicals and n stands for 1 or 2; and acid-addition salts thereof; and the preparation thereof by the interaction of an amino derivative of isoquinoline of general formula <FORM:0973912/C1/1> wherein R1, R2, R3, R4, R5 and R6 have the above meaning and R7 stands for an alkyl radical, with a 1, 3-diketone of formula <FORM:0973912/C1/2> wherein R2 and n have the above meanings, preferably in the presence of a basic condensing agent such as tertiary amine or an alkali metal tertiary alkoxide, and/or a chemical or physical arrangement for removing water formed in the reaction, optionally in the presence of a free radical inhibitor such as p-methoxy-phenol, and an inert diluent or solvent. The reaction may be accelerated or completed by the application of heat. Specifications 973,911 and 973,913 are referred to.
GB2141462A 1962-06-04 1962-06-04 Derivatives of 8-azaoestrane and 8-aza-d-homooestrane Expired GB973912A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BE633213D BE633213A (en) 1962-06-04
GB2141462A GB973912A (en) 1962-06-04 1962-06-04 Derivatives of 8-azaoestrane and 8-aza-d-homooestrane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2141462A GB973912A (en) 1962-06-04 1962-06-04 Derivatives of 8-azaoestrane and 8-aza-d-homooestrane

Publications (1)

Publication Number Publication Date
GB973912A true GB973912A (en) 1964-11-04

Family

ID=10162538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2141462A Expired GB973912A (en) 1962-06-04 1962-06-04 Derivatives of 8-azaoestrane and 8-aza-d-homooestrane

Country Status (2)

Country Link
BE (1) BE633213A (en)
GB (1) GB973912A (en)

Also Published As

Publication number Publication date
BE633213A (en)

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