GB969022A - Substituted ureas - Google Patents
Substituted ureasInfo
- Publication number
- GB969022A GB969022A GB1530861A GB1530861A GB969022A GB 969022 A GB969022 A GB 969022A GB 1530861 A GB1530861 A GB 1530861A GB 1530861 A GB1530861 A GB 1530861A GB 969022 A GB969022 A GB 969022A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- hydrogen
- monocyclic
- aryl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0969022/C1/1> (wherein R is hydrogen, lower alkyl, lower alkenyl, monocyclic aryl or monocyclic aralkyl the aryl groups of which may be halogen, lower alkyl or lower alkoxy substituted; R1 and R11 are hydrogen, lower alkyl or monocyclic aryl, or together with the carbon atom to which they are joined are lower cycloalkyl, or CRR1R11 is phenyl or pyridyl which may be lower alkyl substituted; R111 and R1111 are hydrogen or lower alkyl; the word "lower" referring to groups containing at most 7 carbon atoms; and X is oxygen or sulphur) and salts thereof; and their preparation by reacting the appropriate acyl isocyanate or acyl isothiocyanate with hydroxylamine or the appropriate oxyamine or salt thereof in an organic solvent. Examples are given, and the preparation of salts with alkali and alkaline earth metals, ammonia and pyridine is described. Acyl isocyanate and isothiocyanate starting materials are prepared from acid chlorides and metal cyanates or thiocyanates, the acid chlorides being prepared from the appropriate carboxylic acids and thionyl chloride. 2-Ethyl -2- (p-chlorphenyl) butyric acid is prepared by reacting p-chlorphenylacetonitrile with ethyl iodide to give 2-ethyl-2-(p-chlorphenyl) butyryl nitrile and then hydrolysing this.ALSO:Compounds of the formula <FORM:0969022/A5-A6/1> (wherein R is hydrogen, lower alkyl, lower alkenyl monocyclic aryl or monocyclic aralkyl, the aryl groups of which may be halogen, lower alkyl or lower alkoxy substituted; R1 and R11 are hydrogen, lower alkyl or monocyclic aryl, or together with the carbon atom to which they are joined are lower cycloalkyl, or CRR1R11 is phenyl, or pyridyl which may be lower alkyl substituted; R111 and R1111 are hydrogen or lower alkyl; the word "lower" referring to groups containing at most 7 carbon atoms; and X is oxygen or sulphur) and alkali and alkaline-earth metal, ammonium and pyridine salts thereof, are stated to be useful as C.N.S. depressants, especially as oral hypnotics, and may be administered orally, alone or in combination with phenobartitol, diphenylhydantoin sodium, trimethadione or paramethadione.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1530861A GB969022A (en) | 1961-04-27 | 1961-04-27 | Substituted ureas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1530861A GB969022A (en) | 1961-04-27 | 1961-04-27 | Substituted ureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB969022A true GB969022A (en) | 1964-09-09 |
Family
ID=10056781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1530861A Expired GB969022A (en) | 1961-04-27 | 1961-04-27 | Substituted ureas |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB969022A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2430415A1 (en) * | 1978-07-06 | 1980-02-01 | Duphar Int Res | NOVEL UREA AND THIOURAE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND INSECTICIDE PRODUCTS PREPARED THEREFROM |
| EP0007648A1 (en) * | 1978-08-02 | 1980-02-06 | Investigacion Tecnica Y Aplicada, S.A. | New acylureas with pharmaceutical activity, the process for their preparation, and pharmaceutical compositions which contain them |
-
1961
- 1961-04-27 GB GB1530861A patent/GB969022A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2430415A1 (en) * | 1978-07-06 | 1980-02-01 | Duphar Int Res | NOVEL UREA AND THIOURAE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND INSECTICIDE PRODUCTS PREPARED THEREFROM |
| EP0007648A1 (en) * | 1978-08-02 | 1980-02-06 | Investigacion Tecnica Y Aplicada, S.A. | New acylureas with pharmaceutical activity, the process for their preparation, and pharmaceutical compositions which contain them |
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