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GB967890A - Improvements in antibiotics - Google Patents

Improvements in antibiotics

Info

Publication number
GB967890A
GB967890A GB4386561A GB4386561A GB967890A GB 967890 A GB967890 A GB 967890A GB 4386561 A GB4386561 A GB 4386561A GB 4386561 A GB4386561 A GB 4386561A GB 967890 A GB967890 A GB 967890A
Authority
GB
United Kingdom
Prior art keywords
penicillins
general formula
toxic salts
ylpenicillin
penicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4386561A
Inventor
John Rosindale Housley
Hugh Colin Richards
David Frank Spooner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Priority to GB4386561A priority Critical patent/GB967890A/en
Priority to US240149A priority patent/US3274175A/en
Priority to CH1425962A priority patent/CH415636A/en
Priority to FR917751A priority patent/FR1501706A/en
Publication of GB967890A publication Critical patent/GB967890A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Penicillins of the general formula: <FORM:0967890/C1/1> and non-toxic salts thereof, in which X represents a carboxylic group or a non-toxic ester or amide thereof, and R represents a vicinally bound divalent heterocyclic radical of the general formula: <FORM:0967890/C1/2> in which Y represents a nitrogen atom or the group =CH- and R1 and R2, which may be the same or different, represent hydrogen atoms or lower alkyl radicals, or R1 and R2 together represent a fused benzene ring which may carry substituents, may be prepared by reacting 6-aminopenicillanic acid with an acylating agent capable of providing an acyl radical of the general formula: <FORM:0967890/C1/3> particularly an acid chloride, mixed anhydride or cyclic anhydride. Examples describe the preparation of a number of non-toxic salts of penicillins of the above formula such as 3-carboxyquinoxalin -2-yl-penicillin, 3-carboxypyrid -2-yl-penicillin, 3-carboxy -5, 6-dimethylpyrazin -2- ylpenicillin and 3-carboxyquinol -2- ylpenicillin. Pharmaceutical compositions comprise the above penicillins or non-toxic salts thereof in admixture with a pharmaceutical carrier in a standard medicinal dosage form such as tablets lozenges, solutions or suspensions.
GB4386561A 1961-12-07 1961-12-07 Improvements in antibiotics Expired GB967890A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB4386561A GB967890A (en) 1961-12-07 1961-12-07 Improvements in antibiotics
US240149A US3274175A (en) 1961-12-07 1962-11-26 Penicillin derivatives
CH1425962A CH415636A (en) 1961-12-07 1962-12-05 Process for the preparation of new penicillins
FR917751A FR1501706A (en) 1961-12-07 1962-12-06 Process for the preparation of penicillins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4386561A GB967890A (en) 1961-12-07 1961-12-07 Improvements in antibiotics

Publications (1)

Publication Number Publication Date
GB967890A true GB967890A (en) 1964-08-26

Family

ID=10430667

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4386561A Expired GB967890A (en) 1961-12-07 1961-12-07 Improvements in antibiotics

Country Status (1)

Country Link
GB (1) GB967890A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274175A (en) * 1961-12-07 1966-09-20 Boots Pure Drug Co Ltd Penicillin derivatives
US4034099A (en) 1974-03-29 1977-07-05 The Upjohn Company Compositions and method for treating mastitis in milk animals

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274175A (en) * 1961-12-07 1966-09-20 Boots Pure Drug Co Ltd Penicillin derivatives
US4034099A (en) 1974-03-29 1977-07-05 The Upjohn Company Compositions and method for treating mastitis in milk animals

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