GB967890A - Improvements in antibiotics - Google Patents
Improvements in antibioticsInfo
- Publication number
- GB967890A GB967890A GB4386561A GB4386561A GB967890A GB 967890 A GB967890 A GB 967890A GB 4386561 A GB4386561 A GB 4386561A GB 4386561 A GB4386561 A GB 4386561A GB 967890 A GB967890 A GB 967890A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillins
- general formula
- toxic salts
- ylpenicillin
- penicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Penicillins of the general formula: <FORM:0967890/C1/1> and non-toxic salts thereof, in which X represents a carboxylic group or a non-toxic ester or amide thereof, and R represents a vicinally bound divalent heterocyclic radical of the general formula: <FORM:0967890/C1/2> in which Y represents a nitrogen atom or the group =CH- and R1 and R2, which may be the same or different, represent hydrogen atoms or lower alkyl radicals, or R1 and R2 together represent a fused benzene ring which may carry substituents, may be prepared by reacting 6-aminopenicillanic acid with an acylating agent capable of providing an acyl radical of the general formula: <FORM:0967890/C1/3> particularly an acid chloride, mixed anhydride or cyclic anhydride. Examples describe the preparation of a number of non-toxic salts of penicillins of the above formula such as 3-carboxyquinoxalin -2-yl-penicillin, 3-carboxypyrid -2-yl-penicillin, 3-carboxy -5, 6-dimethylpyrazin -2- ylpenicillin and 3-carboxyquinol -2- ylpenicillin. Pharmaceutical compositions comprise the above penicillins or non-toxic salts thereof in admixture with a pharmaceutical carrier in a standard medicinal dosage form such as tablets lozenges, solutions or suspensions.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4386561A GB967890A (en) | 1961-12-07 | 1961-12-07 | Improvements in antibiotics |
US240149A US3274175A (en) | 1961-12-07 | 1962-11-26 | Penicillin derivatives |
CH1425962A CH415636A (en) | 1961-12-07 | 1962-12-05 | Process for the preparation of new penicillins |
FR917751A FR1501706A (en) | 1961-12-07 | 1962-12-06 | Process for the preparation of penicillins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4386561A GB967890A (en) | 1961-12-07 | 1961-12-07 | Improvements in antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
GB967890A true GB967890A (en) | 1964-08-26 |
Family
ID=10430667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4386561A Expired GB967890A (en) | 1961-12-07 | 1961-12-07 | Improvements in antibiotics |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB967890A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274175A (en) * | 1961-12-07 | 1966-09-20 | Boots Pure Drug Co Ltd | Penicillin derivatives |
US4034099A (en) | 1974-03-29 | 1977-07-05 | The Upjohn Company | Compositions and method for treating mastitis in milk animals |
-
1961
- 1961-12-07 GB GB4386561A patent/GB967890A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274175A (en) * | 1961-12-07 | 1966-09-20 | Boots Pure Drug Co Ltd | Penicillin derivatives |
US4034099A (en) | 1974-03-29 | 1977-07-05 | The Upjohn Company | Compositions and method for treating mastitis in milk animals |
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