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GB962674A - New androstane and 19-nor-androstane derivatives and the preparation thereof - Google Patents

New androstane and 19-nor-androstane derivatives and the preparation thereof

Info

Publication number
GB962674A
GB962674A GB22496/61A GB2249661A GB962674A GB 962674 A GB962674 A GB 962674A GB 22496/61 A GB22496/61 A GB 22496/61A GB 2249661 A GB2249661 A GB 2249661A GB 962674 A GB962674 A GB 962674A
Authority
GB
United Kingdom
Prior art keywords
androstane
preparation
keto
steroids
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22496/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB962674A publication Critical patent/GB962674A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises steroids of the general formula: <FORM:0962674/C1/1> wherein R1 represents H, CH3; R2 represents H, Cl or OH; R3 represents H, H or a H, b OH or keto; R4 represents H, F; R5 represents H, H or CH2; X represents H, OH or =N -CH2CH2OH; Y represents H, H or a H, b OH or a CH3, b -OH or a C2H5, b OH or =N-CH2 CH2OH (at least one of the symbols X and Y represents =N-CH2CH2CH2OH) and the corresponding derivatives unsaturated in the 1, 2-, 4, 5- or 5, 6-position or in the 1, 2- and 4, 5-positions, and the preparation thereof by reacting the required 3-keto, 17-keto or 3, 17-diketo steroids with b -hydroxyethylamine. Therapeutic compositions having androgenic or anobolic activity and which may be administered orally contain as the active ingredient steroids of the above general formula.
GB22496/61A 1960-07-23 1961-06-21 New androstane and 19-nor-androstane derivatives and the preparation thereof Expired GB962674A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM46034A DE1143810B (en) 1960-07-23 1960-07-23 Process for the preparation of new per os therapeutically effective Schiff bases of ketosteroids of the androstane and 19-nor-androstane series

Publications (1)

Publication Number Publication Date
GB962674A true GB962674A (en) 1964-07-01

Family

ID=7305477

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22496/61A Expired GB962674A (en) 1960-07-23 1961-06-21 New androstane and 19-nor-androstane derivatives and the preparation thereof

Country Status (4)

Country Link
CH (1) CH388947A (en)
DE (1) DE1143810B (en)
FR (1) FR1909M (en)
GB (1) GB962674A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863885A (en) * 1958-02-10 1958-12-09 Upjohn Co 17-isonitrosoandrostanes

Also Published As

Publication number Publication date
FR1909M (en) 1963-07-15
CH388947A (en) 1965-03-15
DE1143810B (en) 1963-02-21

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