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GB956615A - New substituted diphenylalkylamines - Google Patents

New substituted diphenylalkylamines

Info

Publication number
GB956615A
GB956615A GB3640361A GB3640361A GB956615A GB 956615 A GB956615 A GB 956615A GB 3640361 A GB3640361 A GB 3640361A GB 3640361 A GB3640361 A GB 3640361A GB 956615 A GB956615 A GB 956615A
Authority
GB
United Kingdom
Prior art keywords
compound
trifluoromethyl
alkylamino
phenyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3640361A
Inventor
Cornelis Van Der Stelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL129009D priority Critical patent/NL129009C/xx
Priority to BE472265D priority patent/BE472265A/xx
Priority to FR931308D priority patent/FR931308A/en
Priority to BE623390D priority patent/BE623390A/xx
Priority to NL63794D priority patent/NL63794C/xx
Priority to GB28596/39A priority patent/GB535904A/en
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB3640361A priority patent/GB956615A/en
Priority to FI178362A priority patent/FI40471B/fi
Priority to SE10829/62A priority patent/SE312344B/xx
Priority to DEN22194A priority patent/DE1244801B/en
Priority to CH1184162A priority patent/CH446392A/en
Priority to DK434962A priority patent/DK110091C/en
Priority to ES281404A priority patent/ES281404A1/en
Priority to FR911788A priority patent/FR1374331A/en
Priority to FR920837A priority patent/FR2700M/en
Publication of GB956615A publication Critical patent/GB956615A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03J—TUNING RESONANT CIRCUITS; SELECTING RESONANT CIRCUITS
    • H03J3/00—Continuous tuning
    • H03J3/02—Details
    • H03J3/12—Electrically-operated arrangements for indicating correct tuning
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03J—TUNING RESONANT CIRCUITS; SELECTING RESONANT CIRCUITS
    • H03J5/00—Discontinuous tuning; Selecting predetermined frequencies; Selecting frequency bands with or without continuous tuning in one or more of the bands, e.g. push-button tuning, turret tuner
    • H03J5/02—Discontinuous tuning; Selecting predetermined frequencies; Selecting frequency bands with or without continuous tuning in one or more of the bands, e.g. push-button tuning, turret tuner with variable tuning element having a number of predetermined settings and adjustable to a desired one of these settings
    • H03J5/04—Discontinuous tuning; Selecting predetermined frequencies; Selecting frequency bands with or without continuous tuning in one or more of the bands, e.g. push-button tuning, turret tuner with variable tuning element having a number of predetermined settings and adjustable to a desired one of these settings operated by hand
    • H03J5/12—Settings determined by a number of separately-actuated driving means which adjust the tuning element directly to desired settings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetically Actuated Valves (AREA)
  • Structure Of Receivers (AREA)

Abstract

The invention comprises compounds of general formula: <FORM:0956615/C2/1> wherein A represents a straight or branched alkylene group containing 2 to 7 carbon atoms, and B represents an alkylamino or dialkylamino group or a saturated mononuclear five- or six-membered heterocyclic group attached to A through a nitrogen atom, which heterocyclic group may carry one or more alkyl groups and-when alkyl substituted-includes at most 12 carbon atoms, (alkyl groups have 1-6C); and their non-toxic acid addition salts; and their preparation by (1) the Grignard reaction of a compound Halo-Mg-A-B1 (B1 is B excepting alkylamino) with a trifluoromethylbenzophenone, (2) the Grignard reaction of a phenyl-magnesium-halide as such or trifluoromethyl-substituted with respectively a compound of formula: <FORM:0956615/C2/2> or <FORM:0956615/C2/3> or (3) dealkylating a compound wherein B is dialkylamino, e.g. by treatment with a cyanogen halide to form an N-cyano-N-alkylamino compound and hydrolysing and decarboxylating this. Ketones II and III may be prepared from phenyl-alkyl-ketones, formaldehyde and amines under Mannich conditions; 4-trifluoromethyl-phenyl-ethyl-ketone is prepared by treating ethylbromide with magnesium, cadmium chloride, and p-trifluoromethyl-benzoyl chloride. In the Provisional Specification B is defined as a basic saturated nitrogen-containing radical containing less than 12 carbon atoms and attached via a basic nitrogen atom, and includes amino. Pharmaceutical compositions comprise a compound I or a non-toxic acid addition salt thereof, in association with a pharmacologically acceptable carrier. Tablets, capsules, injectable solutions, lozenges and inhalation sprays are described. The compounds are analgesics. Specifications 907,825 and 956,616 are referred to.
GB3640361A 1961-10-10 1961-10-10 New substituted diphenylalkylamines Expired GB956615A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
NL129009D NL129009C (en) 1961-10-10
BE472265D BE472265A (en) 1961-10-10
FR931308D FR931308A (en) 1961-10-10 Improvements to tuning devices and indicators for radio receivers
BE623390D BE623390A (en) 1961-10-10
NL63794D NL63794C (en) 1961-10-10
GB28596/39A GB535904A (en) 1961-10-10 1939-10-24 Improvements in or relating to tuning devices and indicators for radio receivers
GB3640361A GB956615A (en) 1961-10-10 1961-10-10 New substituted diphenylalkylamines
FI178362A FI40471B (en) 1961-10-10 1962-10-05
SE10829/62A SE312344B (en) 1961-10-10 1962-10-09
DEN22194A DE1244801B (en) 1961-10-10 1962-10-09 Process for the preparation of diphenylalkylamines and their non-toxic salts
CH1184162A CH446392A (en) 1961-10-10 1962-10-09 Process for the preparation of diphenylalkanolamines
DK434962A DK110091C (en) 1961-10-10 1962-10-09 Process for the preparation of substituted diphenylalkylamines or acid addition salts thereof.
ES281404A ES281404A1 (en) 1961-10-10 1962-10-09 Procedure for the preparation of difenyl alcalamines (Machine-translation by Google Translate, not legally binding)
FR911788A FR1374331A (en) 1961-10-10 1962-10-10 Process for the preparation of substituted diphenylalkylamines
FR920837A FR2700M (en) 1961-10-10 1963-01-09 Substituted diphenylalkylamines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3640361A GB956615A (en) 1961-10-10 1961-10-10 New substituted diphenylalkylamines

Publications (1)

Publication Number Publication Date
GB956615A true GB956615A (en) 1964-04-29

Family

ID=10387817

Family Applications (2)

Application Number Title Priority Date Filing Date
GB28596/39A Expired GB535904A (en) 1961-10-10 1939-10-24 Improvements in or relating to tuning devices and indicators for radio receivers
GB3640361A Expired GB956615A (en) 1961-10-10 1961-10-10 New substituted diphenylalkylamines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB28596/39A Expired GB535904A (en) 1961-10-10 1939-10-24 Improvements in or relating to tuning devices and indicators for radio receivers

Country Status (9)

Country Link
BE (2) BE472265A (en)
CH (1) CH446392A (en)
DE (1) DE1244801B (en)
DK (1) DK110091C (en)
ES (1) ES281404A1 (en)
FI (1) FI40471B (en)
FR (2) FR2700M (en)
GB (2) GB535904A (en)
NL (2) NL129009C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506670A (en) * 1966-09-26 1970-04-14 Upjohn Co 2-hetero-amino-alpha,alpha-diaryl-cycloalkone-methanols and esters thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60132934A (en) * 1983-11-21 1985-07-16 Nippon Shinyaku Co Ltd Butanol derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506670A (en) * 1966-09-26 1970-04-14 Upjohn Co 2-hetero-amino-alpha,alpha-diaryl-cycloalkone-methanols and esters thereof

Also Published As

Publication number Publication date
ES281404A1 (en) 1963-03-16
DE1244801B (en) 1967-07-20
FR2700M (en) 1964-08-03
DK110091C (en) 1968-10-28
NL129009C (en)
NL63794C (en)
FI40471B (en) 1968-10-31
BE623390A (en)
BE472265A (en)
FR931308A (en) 1948-02-19
GB535904A (en) 1941-04-25
CH446392A (en) 1967-11-15

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