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GB952519A - Process for the production of penicillins - Google Patents

Process for the production of penicillins

Info

Publication number
GB952519A
GB952519A GB3684261A GB3684261A GB952519A GB 952519 A GB952519 A GB 952519A GB 3684261 A GB3684261 A GB 3684261A GB 3684261 A GB3684261 A GB 3684261A GB 952519 A GB952519 A GB 952519A
Authority
GB
United Kingdom
Prior art keywords
phenyl
group
acid
cyanomethyl
para
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3684261A
Inventor
Reginald Harold Hall
Harry Davies Hollingworth
Donald Peter Young
Roy Sherlock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Distillers Co Yeast Ltd
Distillers Co Ltd
Original Assignee
Distillers Co Yeast Ltd
Distillers Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Distillers Co Yeast Ltd, Distillers Co Ltd filed Critical Distillers Co Yeast Ltd
Priority to GB3684261A priority Critical patent/GB952519A/en
Publication of GB952519A publication Critical patent/GB952519A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The 6-amino group of 6-aminopenicillanic acid, or a salt thereof, is acylated or thioacylated by reaction with a reactive ester of a carboxylic or thiocarboxylic acid of formula: <FORM:0952519/C2/1> where X and Y may be the same or different, and each is an oxygen atom or sulphur atom, <FORM:0952519/C2/2> is the acyl or thioacyl group it is desired to introduce into the 6-amino group of 6-amino-penicillanic acid, and R1 is a phenyl, cyanomethyl or para-nitro phenyl group when X is oxygen, and a methyl, ethyl, carboxymethyl, phenyl, cyanomethyl or a para-nitro-phenyl group when X is sulphur. Examples describe the reaction of 6-aminopenicillanic acid with carboxymethyl dithiobenzoate, phenyldithioacetate, ethoxydithioformate and 3-isonicotinoyldithiocarbazate.
GB3684261A 1961-10-13 1961-10-13 Process for the production of penicillins Expired GB952519A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3684261A GB952519A (en) 1961-10-13 1961-10-13 Process for the production of penicillins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3684261A GB952519A (en) 1961-10-13 1961-10-13 Process for the production of penicillins

Publications (1)

Publication Number Publication Date
GB952519A true GB952519A (en) 1964-03-18

Family

ID=10391621

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3684261A Expired GB952519A (en) 1961-10-13 1961-10-13 Process for the production of penicillins

Country Status (1)

Country Link
GB (1) GB952519A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391141A (en) * 1966-07-07 1968-07-02 Bristol Myers Co Synthetic cephalosporins
FR2024556A1 (en) * 1968-11-08 1970-08-28 Istituto Biochimico Italiano

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391141A (en) * 1966-07-07 1968-07-02 Bristol Myers Co Synthetic cephalosporins
FR2024556A1 (en) * 1968-11-08 1970-08-28 Istituto Biochimico Italiano

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