GB950744A - Process for the manufacture of 11ª‡:18-dihydroxy-progesterone - Google Patents
Process for the manufacture of 11ª‡:18-dihydroxy-progesteroneInfo
- Publication number
- GB950744A GB950744A GB2790160A GB2790160A GB950744A GB 950744 A GB950744 A GB 950744A GB 2790160 A GB2790160 A GB 2790160A GB 2790160 A GB2790160 A GB 2790160A GB 950744 A GB950744 A GB 950744A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydroxyprogesterone
- hydroxyprogesterone
- ochraceus
- progesterone
- dihydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
Abstract
11a , 18-Dihydroxyprogesterone is prepared by subjecting 18-hydroxyprogesterone to the action of enzymes of the fungus Aspergillus ochraceus (Ciba strain No. 924). The process is preferably conducted by incubating 18-hydroxyprogesterone directly with an aerobically grown culture of A. ochraceus, extracting the fermentation liquor after incubation with a water-immiscible solvent and isolating the 11a , 18-dihydroxyprogesterone, preferably after a preliminary purification of the crude extract, e.g. by solvent distribution or chromatographic absorption. The compound is useful for the synthesis of other 18-oxygenated steroids, e.g. aldosterone or 9a -fluoro-18-hydroxy -corticosterone acetate. Specifications 724,094, 805,602, 808,173 and U.S.A. Specification 2,891,948 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7682759A CH376912A (en) | 1959-08-11 | 1959-08-11 | Process for the preparation of 11a, 18-dihydroxy-progesterone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB950744A true GB950744A (en) | 1964-02-26 |
Family
ID=4535190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2790160A Expired GB950744A (en) | 1959-08-11 | 1960-08-11 | Process for the manufacture of 11ª‡:18-dihydroxy-progesterone |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB950744A (en) |
-
1960
- 1960-08-11 GB GB2790160A patent/GB950744A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3047468A (en) | Method of preparing delta1, 4-3-keto steroids of the pregnane series | |
| US2841531A (en) | Process for splitting racemates | |
| GB950744A (en) | Process for the manufacture of 11ª‡:18-dihydroxy-progesterone | |
| GB1303038A (en) | Pleuromutilin derivatives | |
| DE2705917B2 (en) | Process for the production of 3 ß, 16 ß -dihydroxy-S-androsten-17-one by microbiological hydrolysis | |
| US2721828A (en) | Process for production of 17-ketosteroids | |
| US3011951A (en) | Preparation of 11alpha, 17alpha-dihydroxyprogesterone | |
| US3007950A (en) | 16alpha-hydroxy-5beta-pregnane-3, 11, 20 trione with sepedonium ampullosporum and production thereof | |
| GB891173A (en) | Method for the production of 6-amino-penicillanic acid | |
| GB1161419A (en) | Starch Hydrolyzing Enzyme System for use in Grain Alcohol Fermentation | |
| US2793163A (en) | 11beta-hydroxylation of pregnadienes by coniothyrium helleborine | |
| GB921424A (en) | Process for the manufacture of 11ªá-hydroxy-17ªá-methyl testosterone | |
| US3060101A (en) | Process for the 6beta-hydroxylation of steroids with mortierella | |
| US3031379A (en) | Conversion of steroids with mold spores | |
| US3639212A (en) | Process for the preparation of estrane compound by fermentation | |
| US2967803A (en) | Process for the production of 17beta-acetoxyandrostenes | |
| US3039937A (en) | Preparation of 1-hydroxylated steroids | |
| Abalaka et al. | Influence of media composition on linamarase production by some fungi | |
| US2915439A (en) | Microbiological oxidation of pregnenolone to progesterone | |
| US3055806A (en) | Process for the manufacture of 11alpha, 18-dihydroxy-progesterone | |
| US3029233A (en) | 9alpha-hydroxy-steroids and process for their manufacture | |
| ASAI et al. | MICROBIOLOGICAL HYDROXYLATION OF STEROIDS I. MICROBIOLOGICAL HYDROXYLATION OF PROGESTERONE BY RHIZOPUS | |
| GB1296576A (en) | ||
| US3119748A (en) | Process for 11-hydroxylation of steroids | |
| DE3512328A1 (en) | METHOD FOR PRODUCING 1-METHYL-1,4-ANDROSTADIEN-3,17-DION |