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GB948769A - New alkaloids of the funtumia species and processes for obtaining same - Google Patents

New alkaloids of the funtumia species and processes for obtaining same

Info

Publication number
GB948769A
GB948769A GB5360/60A GB536060A GB948769A GB 948769 A GB948769 A GB 948769A GB 5360/60 A GB5360/60 A GB 5360/60A GB 536060 A GB536060 A GB 536060A GB 948769 A GB948769 A GB 948769A
Authority
GB
United Kingdom
Prior art keywords
funtuphyllamine
alkaloids
funtumia
species
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5360/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OLETTA SA
Original Assignee
OLETTA SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DES60064A external-priority patent/DE1185183B/en
Application filed by OLETTA SA filed Critical OLETTA SA
Publication of GB948769A publication Critical patent/GB948769A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises funtuphyllamine, having the formula: <FORM:0948769/C2/1> together with a process for the isolation of compounds of the general formula: <FORM:0948769/C2/2> (wherein R represents a ketonic or b -hydroxylic group, and R1 an -NH2, -NHCH3 or -N(CH3)2 group) which includes the alkaloids dimethyl funtumafrine, methyl funtumafrine, dimethyl funtuphyllamine, methyl funtuphyllamine and funtuphyllamine, from the ground parts of plants of the genus Funtumia (Apocynaceae), species F. Africana, comprising the steps of (1) subjecting the said parts to solvent extraction, (2) agitating the resulting solution with acid, (3) separating the acid solution and (4) rendering it alkaline, (5) extracting the alkaloid bases with ether, benzene, chloroform, ethanol, or methanol and (6) separating the individual alkaloids thus obtained by chromatography. The invention is illustrated by 3 detailed examples. The alkaloids are of therapeutic interest as hypotensors and anti-inflammatory agents. Specification 900,572 is referred to.
GB5360/60A 1957-09-27 1960-02-15 New alkaloids of the funtumia species and processes for obtaining same Expired GB948769A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE561173T 1957-09-27
BE443246 1957-09-27
LU35817 1958-02-22
LU36147 1958-06-04
DES60064A DE1185183B (en) 1957-09-27 1958-09-27 Process for the extraction and production of cardiac or hormonally active compounds

Publications (1)

Publication Number Publication Date
GB948769A true GB948769A (en) 1964-02-05

Family

ID=27507596

Family Applications (2)

Application Number Title Priority Date Filing Date
GB30862/58A Expired GB900572A (en) 1957-09-27 1958-09-26 Funtumia alkaloids
GB5360/60A Expired GB948769A (en) 1957-09-27 1960-02-15 New alkaloids of the funtumia species and processes for obtaining same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB30862/58A Expired GB900572A (en) 1957-09-27 1958-09-26 Funtumia alkaloids

Country Status (6)

Country Link
BE (1) BE561173A (en)
CH (3) CH370773A (en)
GB (2) GB900572A (en)
LU (2) LU35817A1 (en)
NL (1) NL231702A (en)
OA (1) OA01015A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2494697A1 (en) * 1980-11-21 1982-05-28 Roussel Uclaf NOVEL 3-AMINO-STEROID DERIVATIVES, THEIR SALTS, PROCESS AND PREPARATION INTERMEDIATES, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2494696A1 (en) * 1980-11-21 1982-05-28 Roussel Uclaf NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO STEROIDS AND THEIR SALTS
US9447139B2 (en) 2010-04-09 2016-09-20 The Research Foundation Of State University Of New York Ship inhibitors and uses thereof
WO2015195812A1 (en) 2014-06-17 2015-12-23 The Research Foundation For The State University Of New York Ship inhibition to induce activation of natural killer cells

Also Published As

Publication number Publication date
BE561173A (en) 1960-05-20
LU35817A1 (en)
CH405305A (en) 1966-01-15
GB900572A (en) 1962-07-11
NL231702A (en)
LU36147A1 (en)
CH370773A (en) 1963-07-31
OA01015A (en) 1968-08-07
CH369756A (en) 1963-06-15

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GB948769A (en) New alkaloids of the funtumia species and processes for obtaining same
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