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GB937214A - Oripavine derivatives - Google Patents

Oripavine derivatives

Info

Publication number
GB937214A
GB937214A GB20029/61A GB2002961A GB937214A GB 937214 A GB937214 A GB 937214A GB 20029/61 A GB20029/61 A GB 20029/61A GB 2002961 A GB2002961 A GB 2002961A GB 937214 A GB937214 A GB 937214A
Authority
GB
United Kingdom
Prior art keywords
compounds
general formula
aryl
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20029/61A
Inventor
Kenneth Walter Bentley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J F Macfarlan & Co Ltd
Original Assignee
J F Macfarlan & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J F Macfarlan & Co Ltd filed Critical J F Macfarlan & Co Ltd
Priority to GB20029/61A priority Critical patent/GB937214A/en
Priority to DE19621470023 priority patent/DE1470023A1/en
Priority to SE6049/62A priority patent/SE307137B/xx
Priority to BE618392A priority patent/BE618392A/en
Priority to FR899377A priority patent/FR1965M/en
Publication of GB937214A publication Critical patent/GB937214A/en
Priority to US478738A priority patent/US3474101A/en
Priority to MY196673A priority patent/MY6600073A/en
Priority to US726591A priority patent/US3433791A/en
Priority to US726592A priority patent/US3442900A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises oripavine derivatives of the general formula <FORM:0937214/IV(a)/1> wherein R1 is hydrogen, C1-3 alkyl or aryl and R2 is hydrogen, C1-8 alkyl or C2-8 alkenyl (which may be substituted on carbon atoms 1 to 5 by an alicyclic or aryl group) or a C5-7 alicyclic group (which may be unsubstituted or substituted by a C1-3 alkyl group)-with the proviso that R2 does not contain the system -CH-aryl or -CH-C=C attached to the carbon atom bearing the alcoholic hydroxyl group; salts of these compounds with pharmaceutically acceptable acids; 3-acyl esters of these compounds wherein the phenolic hydroxyl group is esterified with an acid CnH2n+1COOH, where n is 1-3, or with benzoic or nicotinic acid; a process for preparing the compounds of the above formula by demethylating the baine derivatives of the general formula <FORM:0937214/IV(a)/2> by heating with an alkali metal hydroxide in the presence of a suitable solvent; and a process for preparing the 3-acyl esters by reacting a compound of the first general formula above with an acid anhydride or acid chloride. The products have depressant, analgesic, sedative and anti-tussive properties. Specification 925,723 is referred to.
GB20029/61A 1960-09-05 1961-06-02 Oripavine derivatives Expired GB937214A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GB20029/61A GB937214A (en) 1961-06-02 1961-06-02 Oripavine derivatives
DE19621470023 DE1470023A1 (en) 1961-06-02 1962-05-24 Process for the preparation of therapeutically effective new derivatives of oripavin
SE6049/62A SE307137B (en) 1961-06-02 1962-05-29
BE618392A BE618392A (en) 1961-06-02 1962-06-01 Oripavine derivatives
FR899377A FR1965M (en) 1961-06-02 1962-06-01 New derivative of oripavine.
US478738A US3474101A (en) 1960-09-05 1965-08-10 Thebaine and oripavine derivatives
MY196673A MY6600073A (en) 1961-06-02 1966-12-31 Oripavine derivatives
US726591A US3433791A (en) 1960-09-05 1968-05-03 Endoethano nor oripavines and nor thebaines
US726592A US3442900A (en) 1960-09-05 1968-05-03 Endoetheno thebaines and oripavines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB20029/61A GB937214A (en) 1961-06-02 1961-06-02 Oripavine derivatives

Publications (1)

Publication Number Publication Date
GB937214A true GB937214A (en) 1963-09-18

Family

ID=10139177

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20029/61A Expired GB937214A (en) 1960-09-05 1961-06-02 Oripavine derivatives

Country Status (5)

Country Link
DE (1) DE1470023A1 (en)
FR (1) FR1965M (en)
GB (1) GB937214A (en)
MY (1) MY6600073A (en)
SE (1) SE307137B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318886A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 7-hydroxymethyl-7, 8-dihydro-6-amino-6, 14-endoethenocodides and morphide
US3329682A (en) * 1964-07-08 1967-07-04 Reckitt & Sons Ltd 7, 8-dihydro-3', 4'-disubstituted cyclohexeno-(1', 2':14, 8)-codeinones
US3474102A (en) * 1967-12-08 1969-10-21 American Cyanamid Co Substituted 7 - (2 - formyl-1-alkoxyvinyl)-7,8-dihydro-6-(hydroxy or methoxy)-6,14-endo (etheno or ethano) codides and morphides
US7405301B2 (en) 2000-08-25 2008-07-29 Glaxowellcome Australia Ltd. Chemical methods
WO2013007986A1 (en) 2011-07-08 2013-01-17 The University Of Bath Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse
US9206190B2 (en) 2008-12-08 2015-12-08 Euro-Celtique S.A. Dihydroetorphines and their preparation
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
US9834562B2 (en) 2012-12-31 2017-12-05 Rhodes Technologies 7 beta-substituted 6a, 14a-ethenomorphinans and 7beta-substituted 6a, 14a-ethanomorphinans
US10898479B2 (en) 2013-05-30 2021-01-26 Euro-Celtique S.A. Dihydroetorphine for the provision of pain relief and anaesthesia

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3329682A (en) * 1964-07-08 1967-07-04 Reckitt & Sons Ltd 7, 8-dihydro-3', 4'-disubstituted cyclohexeno-(1', 2':14, 8)-codeinones
US3318886A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 7-hydroxymethyl-7, 8-dihydro-6-amino-6, 14-endoethenocodides and morphide
US3474102A (en) * 1967-12-08 1969-10-21 American Cyanamid Co Substituted 7 - (2 - formyl-1-alkoxyvinyl)-7,8-dihydro-6-(hydroxy or methoxy)-6,14-endo (etheno or ethano) codides and morphides
US7405301B2 (en) 2000-08-25 2008-07-29 Glaxowellcome Australia Ltd. Chemical methods
US9206190B2 (en) 2008-12-08 2015-12-08 Euro-Celtique S.A. Dihydroetorphines and their preparation
US9481681B2 (en) 2008-12-08 2016-11-01 Euro-Celtique S.A. Dihydroetorphines and their preparation
US10745406B2 (en) 2008-12-08 2020-08-18 Euro-Celtique S.A. Dihydroetorphines and their preparation
WO2013007986A1 (en) 2011-07-08 2013-01-17 The University Of Bath Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse
JP2015172089A (en) * 2011-07-08 2015-10-01 ザ ユニバーシティ オブ バース Orbinol derivatives and thebinol derivatives useful in the treatment of drug and alcohol abuse
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
US9834562B2 (en) 2012-12-31 2017-12-05 Rhodes Technologies 7 beta-substituted 6a, 14a-ethenomorphinans and 7beta-substituted 6a, 14a-ethanomorphinans
US10898479B2 (en) 2013-05-30 2021-01-26 Euro-Celtique S.A. Dihydroetorphine for the provision of pain relief and anaesthesia

Also Published As

Publication number Publication date
DE1470023A1 (en) 1969-03-27
SE307137B (en) 1968-12-23
FR1965M (en) 1963-08-12
MY6600073A (en) 1966-12-31

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