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GB932662A - Therapeutic compositions comprising butyrospermol - Google Patents

Therapeutic compositions comprising butyrospermol

Info

Publication number
GB932662A
GB932662A GB13221/60A GB1322160A GB932662A GB 932662 A GB932662 A GB 932662A GB 13221/60 A GB13221/60 A GB 13221/60A GB 1322160 A GB1322160 A GB 1322160A GB 932662 A GB932662 A GB 932662A
Authority
GB
United Kingdom
Prior art keywords
butyrospermol
extracted
solvent
evaporation
shea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13221/60A
Inventor
Albert Rakoto Ratsimamanga
Pierre Boiteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laroche Navarron SA
Original Assignee
Laroche Navarron SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laroche Navarron SA filed Critical Laroche Navarron SA
Priority to GB13221/60A priority Critical patent/GB932662A/en
Priority to FR850455A priority patent/FR886M/fr
Publication of GB932662A publication Critical patent/GB932662A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The substance "butyrospermol", i.e. 3b -hydroxy-(13a , 14b , 17b H)-lanosta-7,24-diene, is extracted from "shea-butter" (the kernels of the fruit of the W. African tree butyrospermum Parkii) with CCl4. The fatty materials obtained by evaporation of the solvent are taken up by sodium hydroxide dissolved in pure methanol and the methanol is removed to give a soap which is put on a chromatographic column which is extracted with CHCl3. Evaporation of the solvent gives a mixture of the triterpene alcohols butyrospermol, b -amyrin and "Parkeol" (3b -hydroxy-lanosta-9(11), 24-diene) which is acylated by acetic anhydride in the presence of pyridine and the acetates separated by fractional crystallization or by chromatography on alumina. Pure butyrospermol may then be obtained by hydrolysis of its acetate.ALSO:Pharmaceutical compositions for oral, parenteral and local application, e.g. as tablets, parenteral solutions, balms and ointments and having hormonal, cicatrizing and bactericidal activity comprise a carrier and the compound butyrospermol having the structure <FORM:0932662/VI/1> The butyrospermol may be extracted from the kernels of the fruit of butyrospermam Parkii (shea butter) or the oil mill cakes thereof or from the latex of the breadfruit tree. The extraction from shea-butter is described wherein the raw material is ground with CCl4, and the solvent is removed from the extracted fatty materials which are taken up in NaOH/CH3OH. The methanol is removed and the resultant soap is put in a chromatographic column which is extracted with CHCl3. By evaporation of the solvent a mixture is obtained comprising butyrospermol, b -amyrin and "Parkiol" which may be used in the formulation of the compositions or the butyrospermol extracted therefrom (see Group IV (b)).
GB13221/60A 1960-04-13 1960-04-13 Therapeutic compositions comprising butyrospermol Expired GB932662A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB13221/60A GB932662A (en) 1960-04-13 1960-04-13 Therapeutic compositions comprising butyrospermol
FR850455A FR886M (en) 1960-04-13 1961-01-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13221/60A GB932662A (en) 1960-04-13 1960-04-13 Therapeutic compositions comprising butyrospermol

Publications (1)

Publication Number Publication Date
GB932662A true GB932662A (en) 1963-07-31

Family

ID=10019026

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13221/60A Expired GB932662A (en) 1960-04-13 1960-04-13 Therapeutic compositions comprising butyrospermol

Country Status (2)

Country Link
FR (1) FR886M (en)
GB (1) GB932662A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166542A2 (en) * 1984-06-04 1986-01-02 Amano Pharmaceutical Co., Ltd. Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them
WO2001003712A1 (en) * 1999-07-09 2001-01-18 Astion Development Aps Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement
US6399138B1 (en) 1998-11-13 2002-06-04 Loders Croklaan B.V. Sterol concentrates its application and preparation
WO2002055087A1 (en) * 2001-01-12 2002-07-18 Bsp Pharma Dihydro-triterpenes in the treatment of viral infections, cardiovascular disease, inflammation, hypersensitivity or pain
EP1424073A1 (en) * 2002-11-27 2004-06-02 Loders Croklaan B.V. Anti diarrhoea compositions
US7070815B2 (en) 2002-11-27 2006-07-04 Loders Croklaan Usa Llc Anti diarrhoea compositions

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166542A2 (en) * 1984-06-04 1986-01-02 Amano Pharmaceutical Co., Ltd. Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them
EP0166542A3 (en) * 1984-06-04 1986-07-09 Amano Pharmaceutical Co., Ltd. Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them
US6399138B1 (en) 1998-11-13 2002-06-04 Loders Croklaan B.V. Sterol concentrates its application and preparation
WO2001003712A1 (en) * 1999-07-09 2001-01-18 Astion Development Aps Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement
EP1354595A1 (en) * 1999-07-09 2003-10-22 BSP Pharma A/S Composition containing extracts of butyrospermum parkii and its use as medicament or dietary supplement
AU784718B2 (en) * 1999-07-09 2006-06-01 Bsp Pharma A/S Composition containing extracts of Butyrospermum parkii and the use as medicament or dietary supplement
WO2002055087A1 (en) * 2001-01-12 2002-07-18 Bsp Pharma Dihydro-triterpenes in the treatment of viral infections, cardiovascular disease, inflammation, hypersensitivity or pain
CN1520300B (en) * 2001-01-12 2010-10-06 Bsp医药公司 Dihydro-triterpenes in treatment of viral infections, cardiovascular disease, inflammation, hypersensitivity or pain
EP1424073A1 (en) * 2002-11-27 2004-06-02 Loders Croklaan B.V. Anti diarrhoea compositions
US7070815B2 (en) 2002-11-27 2006-07-04 Loders Croklaan Usa Llc Anti diarrhoea compositions

Also Published As

Publication number Publication date
FR886M (en) 1961-10-23

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