GB929391A - Therapeutic compositions comprising polymeric amines - Google Patents
Therapeutic compositions comprising polymeric aminesInfo
- Publication number
- GB929391A GB929391A GB2397859A GB2397859A GB929391A GB 929391 A GB929391 A GB 929391A GB 2397859 A GB2397859 A GB 2397859A GB 2397859 A GB2397859 A GB 2397859A GB 929391 A GB929391 A GB 929391A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- molecular weight
- binding
- polymer
- acrysol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Orally administrable pharmaceutical compositions for binding bile-acids in the gastro-intestinal tract and having blood cholesterol lowering activity comprise a carrier and a synthetic, non-toxic polymer having a skeleton inert to digestive enzymes and a molecular weight in excess of about 3000 and containing ionizable amino groups, the polymer if water-insoluble having the property of binding at least 30% by weight of the available glycocholic acid into a form incapable of dialysis through a cellulose membrane within 5 minutes when exposed to an equal weight of the acid, and having a moisture content of at least 65% after equilibration with air at 100% humidity at 25 DEG C., and, if water-soluble, having an equivalent weight, based on the ionizable amino groups of at least 500 and the property of binding at least 80% of its weight of glycocholic acid in vitro into a form incapable of dialysis through a cellulose membrane. Suitable polymers are divinyl benzene cross-linked polystyrene quaternary ammonium salt resins, e.g. those sold under the Trade Mark "Dowex 1," linear acrylic type quaternary ammonium salt polymers having a molecular weight of the order of 2,000,000, e.g. those sold under the Trade Marks "Acryloid CQ," and "Acrysol CQ," and its tertiary amine salt "Acrysol CA," polyethyleneimine having an average molecular weight of about 30,000 and a co-polymer of acrylamide and vinyl benzene trimethylammonium chloride in a weight ratio of about 30 : 70 having an equivalent weight of about 302 and an average molecular weight of above 100,000. The compositions may be in conventional forms, e.g. a tablet, elixir, syrup or flavoured aqueous solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74859858A | 1958-07-15 | 1958-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB929391A true GB929391A (en) | 1963-06-19 |
Family
ID=25010129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2397859A Expired GB929391A (en) | 1958-07-15 | 1959-07-13 | Therapeutic compositions comprising polymeric amines |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE580490A (en) |
| GB (1) | GB929391A (en) |
Cited By (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4198395A (en) * | 1976-05-25 | 1980-04-15 | Etablissement Viridis | Novel hypocholesterolemic resin |
| US4340585A (en) | 1978-12-21 | 1982-07-20 | Alfa Farmaceutici, S.P.A. | Salified anionic resin for cholesterol and lipid lowering |
| US4747881A (en) * | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4790991A (en) * | 1985-02-05 | 1988-12-13 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4818539A (en) * | 1985-02-05 | 1989-04-04 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4843098A (en) * | 1985-02-05 | 1989-06-27 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4851392A (en) * | 1985-02-05 | 1989-07-25 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4954339A (en) * | 1987-12-23 | 1990-09-04 | Smith Kline & French Laboratories Limited | Novel polystyrene anion exchange polymers |
| US5098701A (en) * | 1989-12-04 | 1992-03-24 | Smithkline & French Laboratories, Ltd. | Crosslinked pyridinomethacrylate polymers |
| US5110875A (en) * | 1989-06-14 | 1992-05-05 | Smith Kline & Franch Laboratories Limited | Polystyrene anion exchange polymers |
| US5112922A (en) * | 1989-06-14 | 1992-05-12 | Smith Kline & French Laboratories | Polystyrene anion exchange polymers |
| US5230885A (en) * | 1987-12-23 | 1993-07-27 | Smith Kline & French Laboratories Limited | Polystyrene anion exchange polymer pharmaceutical composition |
| US5273740A (en) * | 1989-05-22 | 1993-12-28 | Smithkline & French Laboratories Limited | Polystyrene anion exchange polymers |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5679717A (en) * | 1994-06-10 | 1997-10-21 | Geltex Pharmaceuticals, Inc. | Method for removing bile salts from a patient with alkylated amine polymers |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
| US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| EP1133989A2 (en) * | 1993-08-11 | 2001-09-19 | Geltex Pharmaceuticals, Inc. | Polymer compositions for use in therapy |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US7014846B2 (en) | 1993-08-11 | 2006-03-21 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| WO2010079343A2 (en) | 2009-01-09 | 2010-07-15 | Cambridge Enterprise Limited | Formulations of viable cells for oral delivery |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| WO2012064266A1 (en) | 2010-11-04 | 2012-05-18 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
| WO2012064267A1 (en) | 2010-11-08 | 2012-05-18 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| US8187631B2 (en) | 1999-10-19 | 2012-05-29 | Genzyme Corporation | Direct compression polymer tablet core |
| US8986669B2 (en) | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| US9095509B2 (en) | 2005-09-15 | 2015-08-04 | Genzyme Corporation | Sachet formulation for amine polymers |
| US10512657B2 (en) | 2011-10-28 | 2019-12-24 | Lumena Pharmaceutials Llc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US11267924B2 (en) | 2014-12-18 | 2022-03-08 | Genzyme Corporation | Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes |
| US12145959B2 (en) | 2011-10-28 | 2024-11-19 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
-
1959
- 1959-07-08 BE BE580490A patent/BE580490A/en unknown
- 1959-07-13 GB GB2397859A patent/GB929391A/en not_active Expired
Cited By (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4198395A (en) * | 1976-05-25 | 1980-04-15 | Etablissement Viridis | Novel hypocholesterolemic resin |
| US4340585A (en) | 1978-12-21 | 1982-07-20 | Alfa Farmaceutici, S.P.A. | Salified anionic resin for cholesterol and lipid lowering |
| US4747881A (en) * | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4790991A (en) * | 1985-02-05 | 1988-12-13 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4818539A (en) * | 1985-02-05 | 1989-04-04 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4843098A (en) * | 1985-02-05 | 1989-06-27 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US4851392A (en) * | 1985-02-05 | 1989-07-25 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
| US5230885A (en) * | 1987-12-23 | 1993-07-27 | Smith Kline & French Laboratories Limited | Polystyrene anion exchange polymer pharmaceutical composition |
| US4954339A (en) * | 1987-12-23 | 1990-09-04 | Smith Kline & French Laboratories Limited | Novel polystyrene anion exchange polymers |
| US5273740A (en) * | 1989-05-22 | 1993-12-28 | Smithkline & French Laboratories Limited | Polystyrene anion exchange polymers |
| US5112922A (en) * | 1989-06-14 | 1992-05-12 | Smith Kline & French Laboratories | Polystyrene anion exchange polymers |
| US5110875A (en) * | 1989-06-14 | 1992-05-05 | Smith Kline & Franch Laboratories Limited | Polystyrene anion exchange polymers |
| US5098701A (en) * | 1989-12-04 | 1992-03-24 | Smithkline & French Laboratories, Ltd. | Crosslinked pyridinomethacrylate polymers |
| US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
| US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5840766A (en) * | 1993-06-02 | 1998-11-24 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
| US6060517A (en) * | 1993-06-02 | 2000-05-09 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US7459151B2 (en) | 1993-08-11 | 2008-12-02 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| US7014846B2 (en) | 1993-08-11 | 2006-03-21 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| EP1133989A3 (en) * | 1993-08-11 | 2004-05-12 | Genzyme Corporation | Polymer compositions for use in therapy |
| EP1133989A2 (en) * | 1993-08-11 | 2001-09-19 | Geltex Pharmaceuticals, Inc. | Polymer compositions for use in therapy |
| US6225355B1 (en) | 1994-06-10 | 2001-05-01 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5981693A (en) * | 1994-06-10 | 1999-11-09 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
| US5919832A (en) * | 1994-06-10 | 1999-07-06 | Geltex Pharmaceuticals Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US6066678A (en) * | 1994-06-10 | 2000-05-23 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
| US5917007A (en) * | 1994-06-10 | 1999-06-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
| US5969090A (en) * | 1994-06-10 | 1999-10-19 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5693675A (en) * | 1994-06-10 | 1997-12-02 | Geltex Pharmaceuticals Inc. | Alkylated amine polymers |
| US7399821B2 (en) | 1994-06-10 | 2008-07-15 | Genzyme Corporation | Alkylated poly(allylamine) polymers and methods of use |
| US6433026B2 (en) | 1994-06-10 | 2002-08-13 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
| US7101960B2 (en) | 1994-06-10 | 2006-09-05 | Genzyme Corporation | Process for removing bile salts from a patient and alkylated compositions therefor |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5679717A (en) * | 1994-06-10 | 1997-10-21 | Geltex Pharmaceuticals, Inc. | Method for removing bile salts from a patient with alkylated amine polymers |
| US6784254B2 (en) | 1994-06-10 | 2004-08-31 | Genzyme Corporation | Process for removing bile salts from a patient and alkylated compositions therefor |
| US6610283B1 (en) | 1996-12-30 | 2003-08-26 | Genzyme Corporation | Poly(diallylamine)-based bile acid sequestrants |
| US7125547B2 (en) | 1996-12-30 | 2006-10-24 | Genzyme Corporation | Poly(diallylamine)-based bile acid sequestrants |
| US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
| US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
| US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
| US8187631B2 (en) | 1999-10-19 | 2012-05-29 | Genzyme Corporation | Direct compression polymer tablet core |
| US9931358B2 (en) | 1999-10-19 | 2018-04-03 | Genzyme Corporation | Direct compression polymer tablet core |
| US9579343B2 (en) | 1999-10-19 | 2017-02-28 | Genzyme Corporation | Direct compression polymer tablet core |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US8808738B2 (en) | 2004-11-01 | 2014-08-19 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US9555056B2 (en) | 2004-11-01 | 2017-01-31 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US9895315B2 (en) | 2004-11-01 | 2018-02-20 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US8986669B2 (en) | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
| US9585911B2 (en) | 2005-09-15 | 2017-03-07 | Genzyme Corporation | Sachet formulation for amine polymers |
| US9095509B2 (en) | 2005-09-15 | 2015-08-04 | Genzyme Corporation | Sachet formulation for amine polymers |
| WO2010079343A2 (en) | 2009-01-09 | 2010-07-15 | Cambridge Enterprise Limited | Formulations of viable cells for oral delivery |
| EP3023102A1 (en) | 2010-11-04 | 2016-05-25 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| WO2012064266A1 (en) | 2010-11-04 | 2012-05-18 | Albireo Ab | Ibat inhibitors for the treatment of liver diseases |
| EP3777864A1 (en) | 2010-11-04 | 2021-02-17 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
| WO2012064267A1 (en) | 2010-11-08 | 2012-05-18 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| US10512657B2 (en) | 2011-10-28 | 2019-12-24 | Lumena Pharmaceutials Llc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US11229661B2 (en) | 2011-10-28 | 2022-01-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US11376251B2 (en) | 2011-10-28 | 2022-07-05 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| US12145959B2 (en) | 2011-10-28 | 2024-11-19 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| US11267924B2 (en) | 2014-12-18 | 2022-03-08 | Genzyme Corporation | Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes |
Also Published As
| Publication number | Publication date |
|---|---|
| BE580490A (en) | 1960-01-08 |
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