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GB909080A - Process for the side-chain chlorination of 2-methylpyridines and 2-methylquinolines - Google Patents

Process for the side-chain chlorination of 2-methylpyridines and 2-methylquinolines

Info

Publication number
GB909080A
GB909080A GB30380/61A GB3038061A GB909080A GB 909080 A GB909080 A GB 909080A GB 30380/61 A GB30380/61 A GB 30380/61A GB 3038061 A GB3038061 A GB 3038061A GB 909080 A GB909080 A GB 909080A
Authority
GB
United Kingdom
Prior art keywords
compounds
methylquinolines
methylpyridines
acid
examples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30380/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Raschig F GmbH
Original Assignee
Raschig F GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raschig F GmbH filed Critical Raschig F GmbH
Publication of GB909080A publication Critical patent/GB909080A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Side chain chlorination of the methyl groups in the 2 position in methyl pyridines or quinolines, which may also contain other methyl groups, is effected by reaction, at 40 DEG -80 DEG C., with chlorine in the presence of an inert solvent and also an agent for binding hydrochloric acid. Specified solvents are chloroform, carbon tetrachloride and trichlorethylene whilst carbonates and bicarbonates are examples of the acid binder. In examples 2-picoline; 2,3- and 2,6-lutidine; 2,4,6-collidine, and quinaldine are chlorinated. Monochlor compounds can be separated from di- and/or trichlor compounds by dissolution in acid.
GB30380/61A 1960-11-12 1961-08-23 Process for the side-chain chlorination of 2-methylpyridines and 2-methylquinolines Expired GB909080A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DER29067A DE1204231B (en) 1960-11-12 1960-11-12 Process for the preparation of 2-chloromethyl-pyridines or -quinolines

Publications (1)

Publication Number Publication Date
GB909080A true GB909080A (en) 1962-10-24

Family

ID=7402899

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30380/61A Expired GB909080A (en) 1960-11-12 1961-08-23 Process for the side-chain chlorination of 2-methylpyridines and 2-methylquinolines

Country Status (3)

Country Link
CH (1) CH396908A (en)
DE (1) DE1204231B (en)
GB (1) GB909080A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599345A (en) * 1982-12-02 1986-07-08 Alkaloide Vegyeszeti Gyar Chloromethyl quinoline derivatives and use thereof as analgesics
US4659834A (en) * 1982-12-11 1987-04-21 Alkaloida Vegyeszeti Gyar Process for the preparation of fluoromethyl-quinoline derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2823414B2 (en) * 1992-02-26 1998-11-11 セントラル硝子株式会社 Method for chlorinating side chains of 2-chloro-methylpyridines
DE10256999A1 (en) * 2002-12-06 2004-06-24 Solvay Fluor Und Derivate Gmbh Production of halogenated compounds, especially chlorinated picoline, lutidine and collidine, involves photohalogenation in presence of an acid, e.g. trifluoroacetic acid, which prevents formation of hydrogen halide adducts

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599345A (en) * 1982-12-02 1986-07-08 Alkaloide Vegyeszeti Gyar Chloromethyl quinoline derivatives and use thereof as analgesics
US4659834A (en) * 1982-12-11 1987-04-21 Alkaloida Vegyeszeti Gyar Process for the preparation of fluoromethyl-quinoline derivatives

Also Published As

Publication number Publication date
CH396908A (en) 1965-08-15
DE1204231B (en) 1965-11-04

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