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GB902570A - Preparation of c-alkylated piperazines - Google Patents

Preparation of c-alkylated piperazines

Info

Publication number
GB902570A
GB902570A GB3194158A GB3194158A GB902570A GB 902570 A GB902570 A GB 902570A GB 3194158 A GB3194158 A GB 3194158A GB 3194158 A GB3194158 A GB 3194158A GB 902570 A GB902570 A GB 902570A
Authority
GB
United Kingdom
Prior art keywords
oxide
preparation
atmospheres
alkyl radical
catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3194158A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jefferson Chemical Co Inc
Original Assignee
Jefferson Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jefferson Chemical Co Inc filed Critical Jefferson Chemical Co Inc
Publication of GB902570A publication Critical patent/GB902570A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

In a process for preparing C-alkylated piperazines, a dialkanolamine of the formula: Z.CHOH.CHR1.NH.CRR11.CHR111.OH, in which Z is C1-10 alkyl radical and R, R1, R11 and R111 are each a hydrogen atom or a C1-3 alkyl radical, is reacted at an elevated temperature and under a pressure within a range of 30 to 400 atmospheres with ammonia in the presence of hydrogen having a partial pressure of 10 to 200 atmospheres and a hydrogenation catalyst which comprises at least one metal or oxide of nickel, copper or cobalt. The catalyst may optionally contain a minor amount of a promoter which is chromium oxide, molybdenum oxide, manganese oxide or thorium oxide or a mixture thereof. Tetramethyl pyrazine is also formed as a byproduct in the preparation of 2,3,5,6-tetramethylpiperazine. 1-(2-Hydroxyethylamino)-2-dodecanol is prepared from dodecene oxide and monoethanolamine.
GB3194158A 1957-10-15 1958-10-07 Preparation of c-alkylated piperazines Expired GB902570A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69019957A 1957-10-15 1957-10-15

Publications (1)

Publication Number Publication Date
GB902570A true GB902570A (en) 1962-08-01

Family

ID=24771517

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3194158A Expired GB902570A (en) 1957-10-15 1958-10-07 Preparation of c-alkylated piperazines

Country Status (3)

Country Link
DE (1) DE1140939B (en)
FR (1) FR1206423A (en)
GB (1) GB902570A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235651A1 (en) * 1986-02-18 1987-09-09 BASF Aktiengesellschaft Process for the preparation of N-methylpiperazine
EP0446783A2 (en) * 1990-03-15 1991-09-18 BASF Aktiengesellschaft Procedure for the preparation of N-aryl substituted 2-aminoalkyl-2-hydroxyalkylamines and N-aryl substituted piperazines
EP1031568A1 (en) * 1999-02-24 2000-08-30 Bayer Aktiengesellschaft Process for the preparation of cis-Dimethylpiperazine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525223A (en) * 1948-05-25 1950-10-10 American Cyanamid Co Preparation of n-substituted piperazines

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0235651A1 (en) * 1986-02-18 1987-09-09 BASF Aktiengesellschaft Process for the preparation of N-methylpiperazine
US4845218A (en) * 1986-02-18 1989-07-04 Basf Aktiengesellschaft Preparation of n-methylpiperazine
EP0446783A2 (en) * 1990-03-15 1991-09-18 BASF Aktiengesellschaft Procedure for the preparation of N-aryl substituted 2-aminoalkyl-2-hydroxyalkylamines and N-aryl substituted piperazines
EP0446783A3 (en) * 1990-03-15 1991-11-27 Basf Aktiengesellschaft Procedure for the preparation of n-aryl substituted 2-aminoalkyl-2-hydroxyalkylamines and n-aryl substituted piperazines
US5110928A (en) * 1990-03-15 1992-05-05 Basf Aktiengesellschaft Preparation of n-aryl-substituted 2-aminoalkyl-2-hydroxyalkylamines and n-aryl-substituted piperazines
EP1031568A1 (en) * 1999-02-24 2000-08-30 Bayer Aktiengesellschaft Process for the preparation of cis-Dimethylpiperazine
DE19907829A1 (en) * 1999-02-24 2000-08-31 Bayer Ag Process for the preparation of cis-2,6-dimethylpiperazine
DE19907829C2 (en) * 1999-02-24 2001-05-10 Bayer Ag Process for the preparation of cis-2,6-dimethylpiperazine
US6316622B1 (en) 1999-02-24 2001-11-13 Bayer Aktiengesellschaft Process for preparing cis-2,6-dimethylpiperazine
US6365741B2 (en) 1999-02-24 2002-04-02 Bayer Aktiengesellschaft Process for preparing Cis-2,6-dimethylpiperazine
EP1284262A1 (en) * 1999-02-24 2003-02-19 Bayer Ag Process for the preparation of cis-2,6-dimethylpiperazine

Also Published As

Publication number Publication date
FR1206423A (en) 1960-02-09
DE1140939B (en) 1962-12-13

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